DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10960 and Slc2a1

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_035530.2	Gene:	Slc2a1 / 20525	MGIID:	95755	Length:	492	Species:	Mus musculus

Alignment Length:	493	Identity:	149/493 - (30%)
Similarity:	230/493 - (46%)	Gaps:	66/493 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 LAAAGGAFAAGTVLGWTS---PAETEIVDR------GEGYDFPVDKDQFSWVGS----AMTLGAA 139
            :.|.|||.......|:.:   .|..::::.      ...|..|:.....:.:.|    ..::|..
Mouse    13 MLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGEPIPSTTLTTLWSLSVAIFSVGGM 77

  Fly   140 CVCIPIGFLINMIGRKWTMLFL-VLPFI----LGWTMLIWAVNVSMLYASRFILGIAGGAFCVTA 199
            .....:|..:|..||:.:||.: :|.|:    :|::.|  ..:..||...|||:|:..|......
Mouse    78 IGSFSVGLFVNRFGRRNSMLMMNLLAFVAAVLMGFSKL--GKSFEMLILGRFIIGVYCGLTTGFV 140

  Fly   200 PMYTGEIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIFWLSIICG---ILPLIFGAIFF--- 258
            |||.||::...:||.||:..||.|.:|||.       .::|.|..|.|   :.||:...||.
Mouse   141 PMYVGEVSPTALRGALGTLHQLGIVVGILI-------AQVFGLDSIMGNADLWPLLLSVIFIPAL 198

  Fly   259 -------FMPESPTYLVSKDRSENAIKSI-QWLRGKEYDYEPELAELRETDRE-TKANKVNVWAA 314
                   |.||||.:|:.....||..||: :.|||.. |...:|.|::|..|: .:..||.:...
Mouse   199 LQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTA-DVTRDLQEMKEEGRQMMREKKVTILEL 262

  Fly   315 LNRPVTRKALAISMGLMFFQQVCGINAVIFYASRIFLEANTGIEAE-WATILIGIMQVVATFVST 378
            ...|..|:.:.|::.|...||:.|||||.:|::.||.:|  |::.. :|||..||:....|.||.
Mouse   263 FRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKA--GVQQPVYATIGSGIVNTAFTVVSL 325

  Fly   379 LVVDKLGRRILLLASGISMA----ISTTAIGVYFFLQKQDAAQVVSLGW---LPVASLCLFIIMF 436
            .||::.|||.|.|.....||    :.|.|:           |.:..|.|   |.:.::..|:..|
Mouse   326 FVVERAGRRTLHLIGLAGMAGCAVLMTIAL-----------ALLERLPWMSYLSIVAIFGFVAFF 379

  Fly   437 SIGYGPVPWLMMGELFATDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVV 501
            .:|.||:||.::.|||:...:..|.::||.|||...|:|...|..:....| ...|.:|..|.|:
Mouse   380 EVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCG-PYVFIIFTVLLVL 443

  Fly   502 GVIFVYFAVPETKGKSLNEIQQEL-AGNRSTPQAIPAE 538
            ..||.||.||||||::.:||.... .|..|.....|.|
Mouse   444 FFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEE 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	119/388 (31%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	129/421 (31%)
Slc2a1	NP_035530.2	Sugar_tr	19..467	CDD:278511	142/471 (30%)
		MFS	62..450	CDD:119392	127/411 (31%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	282..288		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..492		4/14 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740