DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10960 and SLC2A14

DIOPT Version :9

Sequence 1:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001273166.1	Gene:	SLC2A14 / 144195	HGNCID:	18301	Length:	535	Species:	Homo sapiens

Alignment Length:	512	Identity:	148/512 - (28%)
Similarity:	243/512 - (47%)	Gaps:	62/512 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ENLLG-----NMVH------TSTSNNSQK-------WPQYVAALAAAG-GAFAAGTVLGWTSPAE 108
            |.|||     .|.|      |||...||.       .|..:.|:..|. |:|..|...|..:..|
Human    10 EVLLGVKQGDEMRHFFFSSQTSTLEKSQNGGVGEEVTPALIFAITVATIGSFQFGYNTGVINAPE 74

  Fly   109 T---EIVDR--GEGYDFPVDK----DQFSWVGSAMTLGAACVCIPIGFLINMIGRKWTMLFLVLP 164
            |   |.:::  .:..:.|..:    :.:|...:..::|.......:|..:|..||:.:||.:.|.
Human    75 TIIKEFINKTLTDKANAPPSEVLLTNLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLL 139

  Fly   165 FILGWTML---IWAVNVSMLYASRFILGIAGGAFCVTAPMYTGEIAQKEIRGTLGSFFQLMITIG 226
            ...|..::   ..|.:|.||...|.::|:..|......|||.|||:...:||..|:..||.|.||
Human   140 AATGGCLMGLCKIAESVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVIG 204

  Fly   227 ILFVYAVGAGVKIFWLSIICG------------ILPLIF-GAIFFFMPESPTY-LVSKDRSENAI 277
            ||.       .:||.|.:|.|            |||.|. .|.....||||.: |:::.:.|||.
Human   205 ILV-------AQIFGLELILGSEELWPVLLGFTILPAILQSAALPCCPESPRFLLINRKKEENAT 262

  Fly   278 KSIQWLRGKEYDYEPELAELR-ETDRETKANKVNVWAALNRPVTRKALAISMGLMFFQQVCGINA 341
            :.:|.|.|.: |...::.|:: |:.|.::..:|.|.........|:.:.||:.|...||:.||||
Human   263 RILQRLWGTQ-DVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINA 326

  Fly   342 VIFYASRIFLEANTGIEAE-WATILIGIMQVVATFVSTLVVDKLGRRILLLASGISMAISTTAIG 405
            |.:|::.||.:|  |::.. :|||..|::..:.|.:|..:|::.|||.|.:.....||..:|.:.
Human   327 VFYYSTGIFKDA--GVQQPIYATISAGVVNTIFTLLSLFLVERAGRRTLHMIGLGGMAFCSTLMT 389

  Fly   406 VYFFLQKQDAAQVVSLGWLPVASLCLFIIMFSIGYGPVPWLMMGELFATDIKGFAGSLAGTSNWL 470
            |...|:.    ....:.::.:.::.:|:..|.||.||:||.::.|||:...:..|.::||.|||.
Human   390 VSLLLKN----HYNGMSFVCIGAILVFVACFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWT 450

  Fly   471 LAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVIFVYFAVPETKGKSLNEIQQELAG 527
            ..|:|...|.:....|| ...|.:|.|..:..:.|.:|.||||:|::..:|.:...|
Human   451 SNFLVGLLFPSAAYYLG-AYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEG 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	110/379 (29%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	119/412 (29%)
SLC2A14	NP_001273166.1	MFS	53..487	CDD:119392	127/448 (28%)
SLC2A14	NP_001273166.1	Sugar_tr	54..504	CDD:278511	134/464 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143893
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740