DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42588 and Gtf3c2

DIOPT Version :9

Sequence 1:	NP_648604.2	Gene:	CG42588 / 39457	FlyBaseID:	FBgn0260965	Length:	2730	Species:	Drosophila melanogaster
Sequence 2:	NP_082177.2	Gene:	Gtf3c2 / 71752	MGIID:	1919002	Length:	907	Species:	Mus musculus

Alignment Length:	801	Identity:	166/801 - (20%)
Similarity:	271/801 - (33%)	Gaps:	245/801 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  2062 APQVTEDPEDADGDCKETVFSNAGRAKRKSTIKAETKLKKIGEALTT------------------ 2108
            :|.....|||.:....|       |.:|::...|...|:::.|.|:|
Mouse   163 SPHPKRPPEDFETPSGE-------RPRRRAAQVALLYLQELAEELSTALPAPPLSGPKSPKVSSP 220

  Fly  2109 --QKSGEGASAKNDFDGDSSDYDLTKDKESSEEYDSEGVDSNEDSISSEGEGSLGDNFSTSKQSK 2171
              .|....||::.:.||.:.|.|.....|..:|.:||....|    ||:.|.....  ||.:...
Mouse   221 TKPKKTRQASSQGEEDGSARDEDFVLQVEGEDEEESEAPSEN----SSDPEPVAPR--STPRGPA 279

  Fly  2172 ANRRGDIDRKRICNRPVN-----VGECQQ--KPLLSRYHHLEARA-----THKW---NEFVQRNY 2221
            |.::....|....|...|     |.:|..  |.|..::|.....|     ..||   :|.....|
Mouse   280 AGKQKPHCRGMAPNGLPNYIMAPVWKCLHLTKDLREQHHSFWEFAEWIPVAWKWQLLSELEAAPY 344

  Fly  2222 ----EAGALFTQLVPSYSKIPEKNTDGMLPPKNTPSMRYSYGKVKNEDDWKQLAPFEGFNKEGEY 2282
                |...||:   .....|||   ||.:...|    |:| ....:.:.|             :.
Mouse   345 LPQEEKSPLFS---VQREGIPE---DGTIYRIN----RFS-SITAHPERW-------------DV 385

  Fly  2283 VGYLGSSIKKLEWVPLPP-KAASQYLLCSVRSKMKTFARHKKLKDEDGLLMLLKCTAKNAGKSWT 2346
            ..:.|..:..|:|.|:|. .|||||:.......|.......:|....|||.|           |.
Mouse   386 SFFTGGPLWALDWCPVPEGSAASQYVALFSSPDMNETHPLSQLHSGPGLLQL-----------WG 439

  Fly  2347 L-----------RPELHYCVHVPNGPIHSFSFLPSGGYDKSSN--------RLGVLAVANSLSSV 2392
            |           |....|.:...:|.|....|.|||.::....        |||:||:|.|...|
Mouse   440 LGTLQQESCPGNRAHFVYGIACDSGCIWDLKFCPSGAWEHPETLRKAPLLPRLGLLALACSDGKV 504

  Fly  2393 HIYALP---LELANDEIDENADEKVVIQLDSLITL---TLDINNPVQ-DQCTKICWSLSAGHSFL 2450
            .:::||   ..||....|  |.:..:.::..|.||   ::..::|.: .||..:.|..:..|..|
Mouse   505 LLFSLPHPEALLAQQPPD--AMKPAIYKVQCLATLQVGSVQASDPSECGQCLSLAWMPTRPHHHL 567

  Fly  2451 ATGYSSGHFALWDIGEKDNL---------------NCFIRNNQ-----------THFVPVNFLYI 2489
            |.||.:|....|::.....|               .||:.::|           :||:    :..
Mouse   568 AAGYYNGMVVFWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTIQWCKANSHFL----VSA 628

  Fly  2490 G-ERNVQYMDLH--YD--NNGPRWLAVGTSIRQFKIYDIANWSNPY---ILTQDTISSLYMANLT 2546
            | :|.:::.||.  |:  |...|:|:...|           |..||   .:.||...:.|
Mouse   629 GSDRKIKFWDLRRPYEPINCIKRFLSTELS-----------WLLPYNGVTVAQDNCYASY----- 677

  Fly  2547 WSPICEALVVSSSHF-FRTIAVSP--------SGIQFEHRTLDGTLTTTREMHTNCQQNHMVFVT 2602
              .:|....:.:.:. |:....:|        ||..:......|.:
Mouse   678 --GLCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTVAAGDI------------------- 721

  Fly  2603 DNGDLVFLDVRNLNCGPALLKSTVNSR-AVSTTELHHLGSSAPSATDPIDPDEFVRDYGLQINPL 2666
             :|:|:...:.::...|..:|.....| .:...:|      .|....|.|     :||. ..:..
Mouse   722 -SGELIAAILPDMASNPINVKKPAERRFPIYKADL------IPYQDSPED-----QDYS-STSSE 773

  Fly  2667 VPEPHKRKS--------------TYLSA-----KRRPQ------NIHS------LAMTRFNCVRC 2700
            .|.|.|.::              |.||:     :|.|.      ..||      |.:...:.||.
Mouse   774 TPNPPKARTYTETINHHYLLFQDTDLSSFHNLLRREPMLRMQEGEGHSQLCLDRLQLEAIHKVRF 838

  Fly  2701 NWNSPTHTWVAMGAEHGMLRI 2721
            :.|..::.|:..|.:.|::||
Mouse   839 SPNLDSYGWLVSGGQSGLVRI 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42588	NP_648604.2	PHA03247	<11..541	CDD:223021
		WD40 repeat	2363..2403	CDD:293791	15/50 (30%)
		WD40 repeat	2437..2477	CDD:293791	11/54 (20%)
		WD40 repeat	2484..2533	CDD:293791	12/56 (21%)
		WD40 repeat	2541..2588	CDD:293791	7/55 (13%)
Gtf3c2	NP_082177.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..186		7/29 (24%)
		HMG17	166..>243	CDD:197773	17/83 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..289		18/91 (20%)
		WD 1	461..517		16/55 (29%)
		WD 2	548..589		11/40 (28%)
		WD40	<554..>719	CDD:225201	34/186 (18%)
		WD40 repeat	554..591	CDD:293791	9/36 (25%)
		WD40	<555..640	CDD:295369	17/88 (19%)
		WD 3	607..647		8/43 (19%)
		WD40 repeat	612..652	CDD:293791	8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..780		6/27 (22%)
		WD 4	828..870		9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_293D8
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006002
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15052
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9435
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030