DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42588 and Gtf3c2

DIOPT Version :9

Sequence 1:	NP_648604.2	Gene:	CG42588 / 39457	FlyBaseID:	FBgn0260965	Length:	2730	Species:	Drosophila melanogaster
Sequence 2:	NP_001020291.1	Gene:	Gtf3c2 / 313914	RGDID:	1560392	Length:	951	Species:	Rattus norvegicus

Alignment Length:	1061	Identity:	208/1061 - (19%)
Similarity:	347/1061 - (32%)	Gaps:	331/1061 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1797 ASEDPEAVEGDSVE------VPIKRKASTRRGSVPRDTPISSVNASDESAVLESV--PK----KG 1849
            ||.:..:||. |:|      :|....:|.:|...|....::.:...|.|:.:..|  |:    .|
  Rat    38 ASSETSSVEA-SIEMSLPPPLPGFEDSSDKRRLPPDQESLTRLEQQDLSSEMAKVSNPRASKPSG 101

  Fly  1850 RRSNISSVPADTTIPKSSKSDSLNAIEIIPPICEE--PKVVPSKRGRKRAAPSD-IETGLAKKLK 1911
            ||.  ...|.....|:..|..|   ..::|.:.::  |...|..:.|.:.:..| :...|:|.|.
  Rat   102 RRG--GRTPRGAKRPQQRKPPS---APLVPGLLDQSNPLSTPMPKKRSQKSKGDLLLLKLSKGLD 161

  Fly  1912 TEESSETERVVDFNLRLLLIRKRDQLDTDEVLTNDGKGQGPLQCGLCLVRSDKNNWQRHIGEHYG 1976
            ..||...:            |..:..:|.       .|:.|.:....:|......|.|
  Rat   162 QPESPHPK------------RPPEDFETP-------SGERPRRRAAQVVSLPNPGWPR------- 200

  Fly  1977 VGWLVGETPKNITRSGIMTMMKNYLQKNGGKLTCRLCNHQLGSYLGMMLHLEGCGNKQRFQCEFC 2041
                ..:.|.:.:|                                 :|.|:.|.........|.
  Rat   201 ----TCDPPNSASR---------------------------------VLGLQACATTPGSPSHFS 228

  Fly  2042 QRSYTKLSLPVHIRTCPKRIAPQVTEDPEDADGDCKETVFSNAGRAKRKSTIKAETKLKKIGEAL 2106
            |.|...|   ::::...:.::   |..|....|             .:...:.:.||.||
  Rat   229 QTSPRAL---LYLQELAEELS---TALPAPLSG-------------PKSPKVSSPTKPKK----- 269

  Fly  2107 TTQKSGEGASAKNDFDGDSSDYDLTKDKESSEEYDSEGVDSNEDSISSEGEGSLGDNFSTSKQSK 2171
            |.|.:.:|     :.||.:.|.|.....|..:|.:||....|    ||:.|.....  ||.:...
  Rat   270 TRQAASQG-----EEDGRARDEDFVLQVEGEDEEESEAPSEN----SSDPEPVAPR--STPRGPA 323

  Fly  2172 ANRRGDIDRKRICNRPVN-----VGECQQ--KPLLSRYHHLEARA-----THKW---NEFVQRNY 2221
            |.::....|....|...|     |.:|..  |.|..:.|.....|     ..||   :|.....|
  Rat   324 AGKQKPHCRGMAPNGLPNYIMAPVWKCLHLTKDLREQQHSFWEFAEWIPVAWKWQLLSELEAAPY 388

  Fly  2222 ----EAGALFTQLVPSYSKIPEKNTDGMLPPKNTPSMRYSYGKVKNEDDWKQLAPFEGFNKEGEY 2282
                |...||:   .....|||   ||.:...|    |:| ....:.:.|             :.
  Rat   389 LPQEEKSPLFS---VQREGIPE---DGTIYRIN----RFS-SITAHPERW-------------DV 429

  Fly  2283 VGYLGSSIKKLEWVPLPP-KAASQYLLCSVRSKMKTFARHKKLKDEDGLLMLLKCTAKNAGKSWT 2346
            ..:.|..:..|:|.|:|. .|||||:.......|.......:|....|||.|           |.
  Rat   430 SFFTGGPLWALDWCPVPEGSAASQYVALFSSPDMNETHPLSQLHSGPGLLQL-----------WG 483

  Fly  2347 L-----------RPELHYCVHVPNGPIHSFSFLPSGGYDKSSN--------RLGVLAVANSLSSV 2392
            |           |....|.:...:|.|....|.|||.::....        |||:||:|.|...|
  Rat   484 LGTLQQESCPGNRAHFVYGIACDSGCIWDLKFCPSGAWEHPETLRKAPLLPRLGLLALACSDGKV 548

  Fly  2393 HIYALP---LELANDEIDENADEKVVIQLDSLITL---TLDINNPVQ-DQCTKICWSLSAGHSFL 2450
            .:::||   ..||....|  |.:..:.::..|.||   ::..::|.: .||..:.|..:..|..|
  Rat   549 LLFSLPHPEALLAQQPPD--AMKPAIYKVQCLATLQVGSVQASDPSECGQCLSLAWMPTRPHHHL 611

  Fly  2451 ATGYSSGHFALWDIGEKDNL---------------NCFIRNNQ-----------THFVPVNFLYI 2489
            |.||.:|....|::.....|               .||:.::|           :||:    :..
  Rat   612 AAGYYNGMVVFWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTIQWCKANSHFL----VSA 672

  Fly  2490 G-ERNVQYMDLH--YD--NNGPRWLAVGTSIRQFKIYDIANWSNPY---ILTQDTISSLYMANLT 2546
            | :|.:::.||.  |:  |...|:|:...|           |..||   .:.||...:.|
  Rat   673 GSDRKIKFWDLRRPYEPINCIKRFLSTELS-----------WLLPYNGVTVAQDNCYASY----- 721

  Fly  2547 WSPICEALVVSSSHF-FRTIAVSP--------SGIQFEHRTLDGTLTTTREMHTNCQQNHMVFVT 2602
              .:|....:.:.:. |:....:|        ||..:......|.:
  Rat   722 --GLCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTVAAGDI------------------- 765

  Fly  2603 DNGDLVFLDVRNLNCGPALLKSTVNSR-AVSTTELHHLGSSAPSATDPIDPDEFVRDYGLQINPL 2666
             :|:|:...:.::...|..:|.....| .:...:|      .|....|.|     :||. ..:..
  Rat   766 -SGELIAAILPDMASNPINVKKPAERRFPIYKADL------IPYQDSPED-----QDYS-STSSE 817

  Fly  2667 VPEPHKRKS--------------TYLSA-----KRRPQ------NIHS------LAMTRFNCVRC 2700
            .|.|.|.::              |.||:     :|.|.      ..||      |.:...:.||.
  Rat   818 TPNPPKARTYTETINHHYLLFQDTDLSSFHNLLRREPMLRMQEGEGHSQLCLDRLQLEAIHKVRF 882

  Fly  2701 NWNSPTHTWVAMGAEHGMLRI 2721
            :.|..::.|:..|.:.|::||
  Rat   883 SPNLDSYGWLVSGGQSGLVRI 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42588	NP_648604.2	PHA03247	<11..541	CDD:223021
		WD40 repeat	2363..2403	CDD:293791	15/50 (30%)
		WD40 repeat	2437..2477	CDD:293791	11/54 (20%)
		WD40 repeat	2484..2533	CDD:293791	12/56 (21%)
		WD40 repeat	2541..2588	CDD:293791	7/55 (13%)
Gtf3c2	NP_001020291.1	PHA03247	<54..268	CDD:223021	46/300 (15%)
		WD40 repeat	598..635	CDD:293791	9/36 (25%)
		WD40	<599..684	CDD:421866	17/88 (19%)
		WD40 repeat	656..696	CDD:293791	8/43 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006002
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15052
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100