DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42588 and sfc6

DIOPT Version :9

Sequence 1:	NP_648604.2	Gene:	CG42588 / 39457	FlyBaseID:	FBgn0260965	Length:	2730	Species:	Drosophila melanogaster
Sequence 2:	NP_595930.1	Gene:	sfc6 / 2540424	PomBaseID:	SPBC21H7.05	Length:	582	Species:	Schizosaccharomyces pombe

Alignment Length:	708	Identity:	138/708 - (19%)
Similarity:	232/708 - (32%)	Gaps:	247/708 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2115 ASAKNDFDGDSSDYDLTKDKESSEEYDSEGVDSNEDSI-------------------SSEGEGS- 2159
            :|.|||.|.|.....:.::..|.|:.:.|....|...:                   ||:|.|:
pombe    12 SSYKNDEDNDDDGDFVLENVMSEEDIEIETPSRNRKRVSTTRRTPSKPIRSQPLTPSSSKGAGNE 76

  Fly  2160 -LGDNFSTSKQS--KANRRGDIDRKRICNRPVNVGECQQKPLLSRYHHLEA-----RATHKWNEF 2216
             ...|.||::.|  |.:.:|                .::|.:.|...|:|:     |....|
pombe    77 PKSQNSSTTRGSAKKQSSKG----------------LEEKLINSYGTHVESLNKGRRLIEIW--- 122

  Fly  2217 VQRNYEAG---ALFTQLVPSYSKIPE-KNTDG--MLPPKNTP---------SMRYSYGKVKNEDD 2266
              :.||..   :.|.....|.||:.. .|.||  :|.....|         |:.:.:...:..:.
pombe   123 --KYYETAPGQSSFEGQTSSDSKLQTLLNLDGQQLLSYSENPFYLFEVKNLSISFHFESPQQVEP 185

  Fly  2267 WKQLAPFEGFNKEGEYVGYLGSSIKKLEWVPLPPKAASQYLLCSVRSK---------MKTFARHK 2322
            .:.:.||:...::..:|...|..:..:.|  ||....:|:|......|         |:|..|::
pombe   186 CQPVNPFKENPQKSGFVVNTGIPLSSVSW--LPTNKETQFLAVGGMLKFSETTESVFMRTSGRNQ 248

  Fly  2323 KLKDEDGLLMLLKCTAKNAGKS-------WTLRPELHYC--VHVPNGPIHSFSFLPSGGYDKSSN 2378
                    :.|.|...|...||       |....:|.:|  :.|.:..:...:.:.|.|
pombe   249 --------IQLWKLENKTNFKSEFILYHDWGSVLQLEWCPTISVEDSILGFLAVVCSDG------ 299

  Fly  2379 RLGVLAVANSLSSVHIYALPLELANDEIDENADEKVVIQLDSLITLTLDINNPVQDQCTKICWSL 2443
            :|.||.|..|....|::.           |.||            .|...|:.:...||.:....
pombe   300 KLRVLRVPRSPVKFHVFV-----------EQAD------------FTFGFNDSLISCCTWVSPEH 341

  Fly  2444 SAGHSFLATGYSSGHFALWDIGEKDNLNCFIRNNQTHFVPVNFLYIGERNVQYMDLHYDNNGPRW 2508
            ...|..| .|.|:|:.|||||........|       ::|.:..|| ...||.:|     :.| |
pombe   342 GDIHQIL-VGCSNGYLALWDILSSQECPLF-------YIPYHDSYI-HNVVQCLD-----DFP-W 391

  Fly  2509 LAVGTSI----RQFKIYDIANWSNPYILTQDTISSLYMANLTWSPICEALVVSSSHFFRTIAVSP 2569
            |.:.|:.    |.|.|.|....:.|....:|...:     :||:.:.::::..|..  :::.:
pombe   392 LFLTTAFDCYTRIFDIRDPIIDNRPLSHKRDICYT-----ITWNNMLQSIISCSES--QSVVI-- 447

  Fly  2570 SGIQFEHRTLDGTLTTTREMHTNCQQNHMVFVTDNGDLVFLDVRNLNCGPALLKSTVNSRAVSTT 2634
                   .:|.||.|.                       .||.||   |..:        ::|.:
pombe   448 -------ESLRGTSTQ-----------------------LLDERN---GSII--------SLSNS 471

  Fly  2635 ELHHLGSSAPSATDPIDPDEFVRDYGLQINP--LVPEPHKRKSTYLSAKRRPQNIHSLAMTRF-- 2695
            :.|...:.|.|       |..|    ..:||  |:...||:|:          |:|.:....:
pombe   472 KFHPFVACAAS-------DGIV----TIVNPFRLLGFSHKQKA----------NVHRIFQLEYSE 515

  Fly  2696 --------------------------------NCVRCNWNSPTHTWVAMGAEHGMLRI 2721
                                            |.|..|.|.....|:|.|...|:||:
pombe   516 KQDSYRMLDGFRPRLPKAKKLDMYIYPWQIQVNKVEWNGNKGYAGWLASGMACGILRV 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42588	NP_648604.2	PHA03247	<11..541	CDD:223021
		WD40 repeat	2363..2403	CDD:293791	8/39 (21%)
		WD40 repeat	2437..2477	CDD:293791	12/39 (31%)
		WD40 repeat	2484..2533	CDD:293791	14/52 (27%)
		WD40 repeat	2541..2588	CDD:293791	7/46 (15%)
sfc6	NP_595930.1	DUF4048	<34..>95	CDD:289997	12/60 (20%)
		WD40	42..500	CDD:225201	114/593 (19%)
		WD40	<243..445	CDD:295369	56/260 (22%)
		WD40 repeat	274..326	CDD:293791	15/80 (19%)
		WD40 repeat	331..373	CDD:293791	13/49 (27%)
		WD40 repeat	381..417	CDD:293791	11/41 (27%)
		WD40 repeat	424..457	CDD:293791	7/71 (10%)
		WD40 repeat	465..499	CDD:293791	9/52 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006002
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15052
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100