DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sf3a2 and PRP11

DIOPT Version :9

Sequence 1:	NP_648603.1	Gene:	Sf3a2 / 39456	FlyBaseID:	FBgn0036314	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_010241.1	Gene:	PRP11 / 851518	SGDID:	S000002201	Length:	266	Species:	Saccharomyces cerevisiae

Alignment Length:	261	Identity:	75/261 - (28%)
Similarity:	112/261 - (42%)	Gaps:	51/261 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFQNRAGGKTGSGGVASWSETNRDRKERLRQLALE------TIDLNKD------PYFMKNHLGS 53
            |::....|.|.|.||:||.|:.|..|::.:..|..:      |....||      ||..|||.|.
Yeast     1 MNYLEGVGSKKGGGGIASESQFNLQRRKEVESLLSKGENVPYTFQDEKDDQVRSNPYIYKNHSGK 65

  Fly    54 YECKLCLTLHNNEGSYLAHTQGKKHQDNLARRAAKEAKEAPSSL---------LAPEKPRVEPKK 109
            ..||||.|:|.:..|...|..||||..|:.||.....|   |||         ...::..:|.|:
Yeast    66 LVCKLCNTMHMSWSSVERHLGGKKHGLNVLRRGISIEK---SSLGREGQTTHDFRQQQKIIEAKQ 127

  Fly   110 FVKIGR--PGYRVTKQRELSNGQQSLLFQVDY-PEITESIV---------PRHRFMSAYEQKIEP 162
            .:|...  |..::...:...||...|..||:| .|:.|:.|         |..|.:|..|.. :.
Yeast   128 SLKNNGTIPVCKIATVKNPKNGSVGLAIQVNYSSEVKENSVDSDDKAKVPPLIRIVSGLELS-DT 191

  Fly   163 PDRKWQYLLFAAEPYETIGFKVPSREVEKSE--------------GKFWTHWNRDTKQFFLQFAF 213
            ..:..::|:.|.||:|.|..::|..|:..||              .|..|.|:..:|.:::||.|
Yeast   192 KQKGKKFLVIAYEPFENIAIELPPNEILFSENNDMDNNNDGVDELNKKCTFWDAISKLYYVQFFF 256

  Fly   214 K 214
            |
Yeast   257 K 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3a2	NP_648603.1	PRP11	1..214	CDD:227571	73/259 (28%)
		ZnF_U1	52..85	CDD:197732	14/32 (44%)
		SF3A2	129..207	CDD:293440	26/101 (26%)
PRP11	NP_010241.1	PRP11	1..262	CDD:227571	75/261 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5246
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I1600
Isobase	1	0.950	-	0	Normalized mean entropy	S781
OMA	1	1.010	-	-		QHG53497
OrthoFinder	1	1.000	-	-		FOG0004594
OrthoInspector	1	1.000	-	-		oto100176
orthoMCL	1	0.900	-	-		OOG6_102158
Panther	1	1.100	-	-	LDO	PTHR23205
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1286
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.780