DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sf3a2 and repo-1

DIOPT Version :9

Sequence 1:	NP_648603.1	Gene:	Sf3a2 / 39456	FlyBaseID:	FBgn0036314	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_502290.1	Gene:	repo-1 / 178147	WormBaseID:	WBGene00008683	Length:	222	Species:	Caenorhabditis elegans

Alignment Length:	216	Identity:	172/216 - (79%)
Similarity:	191/216 - (88%)	Gaps:	2/216 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFQNRAGGKTGSGGVASWSETNRDRKERLRQLALETIDLNKDPYFMKNHLGSYECKLCLTLHNN 65
            ||||||||||||||||||.::...||:|||||||||||||.||||||:||:|:||||||||||||
Worm     1 MDFQNRAGGKTGSGGVASAADAGVDRRERLRQLALETIDLQKDPYFMRNHIGTYECKLCLTLHNN 65

  Fly    66 EGSYLAHTQGKKHQDNLARRAAKEAKEAPSSLLAPEKPRVEPKKFVKIGRPGYRVTKQRELSNGQ 130
            ||||||||||||||.|||||||||..|.| .|.||:|..||.|||||||||||:|||:|:...||
Worm    66 EGSYLAHTQGKKHQANLARRAAKEQSEQP-FLPAPQKAAVETKKFVKIGRPGYKVTKERDPGAGQ 129

  Fly   131 QSLLFQVDYPEITESIVPRHRFMSAYEQKIEPPDRKWQYLLFAAEPYETIGFKVPSREVEKSEGK 195
            |:||||:|||||.:.|.|||||||||||||:|||::|||||||||||||||||:|||||:||| |
Worm   130 QALLFQIDYPEIADGIAPRHRFMSAYEQKIQPPDKRWQYLLFAAEPYETIGFKIPSREVDKSE-K 193

  Fly   196 FWTHWNRDTKQFFLQFAFKFE 216
            |||.||:||||||||.|||.|
Worm   194 FWTMWNKDTKQFFLQVAFKLE 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3a2	NP_648603.1	PRP11	1..214	CDD:227571	169/212 (80%)
		ZnF_U1	52..85	CDD:197732	30/32 (94%)
		SF3A2	129..207	CDD:293440	63/77 (82%)
repo-1	NP_502290.1	PRP11	1..213	CDD:227571	170/213 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158708
Domainoid	1	1.000	168	1.000	Domainoid score	I2314
eggNOG	1	0.900	-	-		E1_COG5246
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133823
Inparanoid	1	1.050	358	1.000	Inparanoid score	I1297
Isobase	1	0.950	-	0	Normalized mean entropy	S781
OMA	1	1.010	-	-		QHG53497
OrthoDB	1	1.010	-	-		D1320891at2759
OrthoFinder	1	1.000	-	-		FOG0004594
OrthoInspector	1	1.000	-	-		oto18699
orthoMCL	1	0.900	-	-		OOG6_102158
Panther	1	1.100	-	-	LDO	PTHR23205
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1286
SonicParanoid	1	1.000	-	-		X3809
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750