DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sap130 and Sap130

DIOPT Version :9

Sequence 1:	NP_729834.1	Gene:	Sap130 / 39455	FlyBaseID:	FBgn0262714	Length:	1294	Species:	Drosophila melanogaster
Sequence 2:	XP_006526012.1	Gene:	Sap130 / 269003	MGIID:	1919782	Length:	1077	Species:	Mus musculus

Alignment Length:	1391	Identity:	295/1391 - (21%)
Similarity:	482/1391 - (34%)	Gaps:	446/1391 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAPSEGGAGGGPVG------------------GGSTATAPSAPLKTIKIRTQQLHTHAVPSLSL 47
            :|.|....|..|..|                  |......||:.|...:.:.:.:.....|.:.:
Mouse    36 LSQPPSQIASSGSAGLINQVATVNDEAGRDADVGTREHVGPSSSLPPREEKQEPVVVRPYPQVQM 100

  Fly    48 LPSIYPSSSSSSLAATG---------SLSASASLVSHSHPPLQLRGVINKYSLPSHLPSSAAHPA 103
            ||:.:..:|::.:|.|.         .||.|..|:.   ||       .|.::||. |.:.|.|
Mouse   101 LPAHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMK---PP-------PKPTMPSR-PIAPAPP- 153

  Fly   104 VAAKITHVKSDGGGGISIAGTPILSGGTIKVASANQVQQTSLGGTPIALNAGQATTAASIRAIGA 168
                            |....|....|.:.|...:.:.|.|  ..|:|..:||....:::..|
Mouse   154 ----------------STMSLPPKVPGQVTVTMESSIPQAS--AIPVATISGQQGHPSNLHHI-- 198

  Fly   169 GGQSTQVRVVMPMIKQLENVTA----TGRTQITAIPAAPARSGANASITVTRPVTQATYLPRASV 229
              .:|.|:  |.:|:  .|...    .|.:.:....||.|...::...||.||.:|   ||.|
Mouse   199 --MTTNVQ--MSIIR--SNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQ---LPNA-- 252

  Fly   230 TATQMGGVGVGVGQRLVTPLRATSSATVTPTAPTVLSSTGG--------FVRGATASVSRSGVAL 286
             ||....|...:.|.:.:....|:|:|:.|.....:|:|..        ....|.:::||..:::
Mouse   253 -ATAQPAVQHLIHQPIQSRPPVTTSSTIPPAVVATVSATRAQSPVITTTAAHAADSTLSRPTLSI 316

  Fly   287 TSQPSSAVISSSNSGAWMQSQGQVQLIRT---------IHQPRQRIITTSAGVSNASVVTT-TPV 341
            ...||:|:.        :|...|.:.:.|         :..|:|::.|    ::..::.:| |||
Mouse   317 QHPPSAAIS--------IQRPAQSRDVTTRITLPSHPALGTPKQQLHT----MAQKTIFSTGTPV 369

  Fly   342 QAPTALSVSAGQPLATQQATGPGGGPQAYVATV----LPQRQHQATLVYSSNVSAPNASQNPGQQ 402
            .|.|...:.|...|.:....|.....||..:|:    :|.....||.|.:||:  |.|...|.|
Mouse   370 AAATVAPILATNTLPSTTTAGSVSHTQAPTSTIVTMTMPSHSSHATAVTTSNI--PVAKVVPQQ- 431

  Fly   403 FNPRFAVATPTGGVTTTTPGGTTVTPRQVRP---------IPLGKSFPTAKLNTTSISIR---AP 455
                         :|.|:|        :::|         ||:  |...|..|..::..|   .|
Mouse   432 -------------ITHTSP--------RIQPDYPPERSSLIPI--SGHRASPNPVAMETRNDNRP 473

  Fly   456 SIP-QLNTSVTASPTAVSVSGGATVAPGRGPGAGGTALTATNLPTT---RIIQLQQPATGTTQQI 516
            |:| |....:...|            |...|.|..|....|:..:|   ..:..|.|.:..|.|
Mouse   474 SVPVQFQYFLPTYP------------PSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSTITAQ- 525

  Fly   517 IGSGARLAGNVMLQPFLMSTTAAAK----MGIRPPVTMTAKVQPSLTITQLNPIGKLSAGGGSGG 577
              :|..:|..|.|.|..:.|..|:.    .||:|....|..:||:
Mouse   526 --TGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPA-------------------- 568

  Fly   578 QTMGPQGVASIQAVPVPNVSASVVNSSSVTGATSAAGGATVLPLTISGRGAGVGPGGNILTGTLT 642
                |.|.:.||..|:           ...|..|||
Mouse   569 ----PIGTSGIQPAPI-----------GTPGIHSAA----------------------------- 589

  Fly   643 PIKNASGITLGKMMMAPASSAPGADGSSTS-----GATVTGFQRTWNPVVASQSQLMKIDEKGSA 702
            ||.     |.|....|.|:..|..:|.:::     |||:..     ||:
Mouse   590 PIN-----TQGLQPAAMANQQPQPEGKTSAVVLADGATIVA-----NPI---------------- 628

  Fly   703 ATIYYESMPASASTGVLSLTTTTVTQSTQAQAQLVSSAGGSLSVSSLPFASHATAGAGSGGGGSQ 767
                  |.|.||:.     ..|||.|:....|...:.|.||....|:.....||
Mouse   629 ------SNPFSAAP-----AATTVVQTHSQSASTNTPAQGSSPRPSILRKKPAT----------- 671

  Fly   768 ATFTVLPSGAGGTATRTIGHQQLIIPAGPNSAPPQHMVIPLHTSVKVTTGAGNPQQATASGALVS 832
                      .|.|.|    :.|:.|..|:.|.|:                            |.
Mouse   672 ----------DGMAVR----KTLLPPQPPDVATPR----------------------------VE 694

  Fly   833 SFMRKRDAEGSPIRAAKNLGPTLLSMASNNSGQNMPPAPGTTFNIQPVSVTVPQSVGSGLTVEAL 897
            |.|  |.|.|||                       .||.....:...||:..|.:|    ::|.:
Mouse   695 SSM--RSASGSP-----------------------RPAGAKPKSEVHVSIATPVTV----SLETI 730

  Fly   898 AKKERERVTHGVASSAASVPATVGPVNSTRNSRADSPASSDGSTTVSANSSPGVDQQLQDRIGDQ 962
            :.:..|:.|..|..:|...|.|:..:.:     |.||.|   ...::.::.||.          .
Mouse   731 SNQNAEQPTVAVPPTAQQPPPTIPSMIA-----AASPPS---QPAIALSTIPGA----------V 777

  Fly   963 PATGGAGGRDNSTHFNPINEMYSSHQSIQQNLGHSSLGARSGSSAFVDVQAPTP-----QQQQPQ 1022
            |.|            .||..:.::          .:|.|..|.:....:..|.|     ::.:|.
Mouse   778 PVT------------PPITTIAAT----------PTLSAPVGGTPSTVLGPPVPEIKVKEEAEPV 820

  Fly  1023 QVPHLVGSTQMQQGTRMNGTGNSSSSSYDCSSRKKPRRSTNDSQHSTQSQAS-LSLPPPSSEP-T 1085
            .:...|.:.                          |..:||....|....|| ||:||....| .
Mouse   821 DITRPVSTV--------------------------PPLATNTVSPSLALLASNLSMPPSDLPPGA 859

  Fly  1086 PPAGASYMQKH----NNGGLLVTAATPG--VAPNSAPGDANHRNSTPAVAGNKENANPVDFVIRR 1144
            .|......|:|    ..|.::.|.:|..  .|..|....|..|.|.|....::|.   |.:|..|
Mouse   860 SPRKKPRKQQHVISTEEGDMMETNSTDDEKSAAKSLLVKAEKRKSPPKEYIDEEG---VRYVPVR 921

  Fly  1145 PR-NCALLNTYKPTHKLANNHFHRYTDVKPREERRATVIDLANQPNVQGKINGWKIYHLRSQMED 1208
            || ...||..|:...|.|.:||.||:||:.:||::|.:.::|||..|..:..|||::...:|:..
Mouse   922 PRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQ 986

  Fly  1209 LNESEVFSLGRLETMLQDL--EKDKEKHSEIERVTELLKGNIQRSKIITDGINEAQNQLMKIFEH 1271
            |...|.....||..:.:.:  :|......::.|:.||::||:||.|::.|.|:||::.::|:.:|
Mouse   987 LTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDH 1051

  Fly  1272 KPHVSNIITRCASKR---NFKKREKI 1294
            |..|..::.:..:.:   ..|::||:
Mouse  1052 KDRVLKLLNKNGTVKKVSKLKRKEKV 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sap130	NP_729834.1	SAP130_C	<1138..1275	CDD:292633	47/139 (34%)
Sap130	XP_006526012.1	PHA03247	<8..359	CDD:223021	76/370 (21%)
		PHA02732	<257..486	CDD:165099	56/259 (22%)
		SAP130_C	655..1060	CDD:374297	73/414 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832157
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	113	1.000	Inparanoid score	I4835
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007229
OrthoInspector	1	1.000	-	-		oto95391
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13497
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5197
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.110