DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg1 and ATG1

DIOPT Version :9

Sequence 1:	NP_001163433.1	Gene:	Atg1 / 39454	FlyBaseID:	FBgn0260945	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_011335.1	Gene:	ATG1 / 852695	SGDID:	S000003148	Length:	897	Species:	Saccharomyces cerevisiae

Alignment Length:	986	Identity:	257/986 - (26%)
Similarity:	398/986 - (40%)	Gaps:	268/986 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YSSKDMLGHGAFAVVYKGR---HRKKHMPVAIKCITKKGQLKTQNLLGK---EIKILKELTELHH 67
            |:::..:|.|:||.||:|.   .:.:|  ||||.:: :.:||.:.||..   ||.|||   ::.|
Yeast    24 YTAEKEIGKGSFATVYRGHLTSDKSQH--VAIKEVS-RAKLKNKKLLENLEIEIAILK---KIKH 82

  Fly    68 ENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSED------------------------ 108
            .::|.|:||:.:.....|:||||..|||...|..:..|.|:
Yeast    83 PHIVGLIDCERTSTDFYLIMEYCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLHRA 147

  Fly   109 TVRLFLVQLAGAMKALYTKGIVHRDLKPQNILLS------------HNYG----KTLPAPSKITL 157
            .|..:|.|||.|:|.|.:|.:||||:||||:|||            |..|    ..||     .|
Yeast   148 FVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLP-----IL 207

  Fly   158 KIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLGTIVYQCLTGKAPFYAQTP 222
            |||||||||||...::|.||||||:|||||::...:|::||||||:||:|::...|..||.|.
Yeast   208 KIADFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVVFEMCCGTPPFRAS-- 270

  Fly   223 NELKSYYE-QNANLAPKIPS--GVSPDLRDLLLCLLRRNSKDRISYESFFVHRFLQGKKAAVSPG 284
            |.|:.:.: :.||.....||  .:.|:|::|:..||..:...||.:|.||.::.:....::..
Yeast   271 NHLELFKKIKRANDVITFPSYCNIEPELKELICSLLTFDPAQRIGFEEFFANKVVNEDLSSYE-- 333

  Fly   285 EPSQAANLRRRVSKSGVLPVDMPPLGGTPPAKAKSPLQQQLEQELKLVK--------LAEQQQKE 341
                             |..|:|.|    .:|:|..::..:.....|.|        ||..|...
Yeast   334 -----------------LEDDLPEL----ESKSKGIVESNMFVSEYLSKQPKSPNSNLAGHQSMA 377

  Fly   342 REEQEAQEDENTVSVVANPAICATITNVGVLCDSENN---SGSCSSHEDSDDFVLVPKNLPEDQR 403
            ....|..:.....:::..||:....|. .|...:.||   :...|......::|:|.|...|  .
Yeast   378 DNPAELSDALKNSNILTAPAVKTDHTQ-AVDKKASNNKYHNSLVSDRSFEREYVVVEKKSVE--V 439

  Fly   404 QGLAQVQAQPASGG---QRPQQQQNQS-------SPPRPSSLPISEPKPVPAPARRQVARPGPL- 457
            ..||...||.....   :.|...|||:       ||......            :.|...|..|
Yeast   440 NSLADEVAQAGFNPNPIKHPTSTQNQNVLLNEQFSPNNQQYF------------QNQGENPRLLR 492

  Fly   458 -TVATLGGQQIPRSQPISVKQPRP---DQRKSSVSSDINSISPP-AVQFAIGTPPTRMRSASGGS 517
             |.::.||....|         ||   |:|.|     |:|::|. |:..|:|...||:   .||:
Yeast   493 ATSSSSGGSDGSR---------RPSLVDRRLS-----ISSLNPSNALSRALGIASTRL---FGGA 540

  Fly   518 LSETPPPHAPSTWQVSPGHSQSPLRRSGNSS--PVLPSAALTKLPTLGSPTMLVAPGS-----LG 575
            ..:.......|    ||.:||:.|    ||.  ..|....:.::..|..|..|....:     |.
Yeast   541 NQQQQQQQITS----SPPYSQTLL----NSQLFHELTENIILRIDHLQHPETLKLDNTNIVSILE 597

  Fly   576 SIGSAG----SGSENNNQHHMLGPRAFTLPELGATGGLHSLLDTGAGGGGEPHAFQAPELSEETL 636
            |:.:..    |.:|  .:...:.|.:.||..:.......| :|:.|             ::||..
Yeast   598 SLAAKAFVVYSYAE--VKFSQIVPLSTTLKGMANFENRRS-MDSNA-------------IAEEQD 646

  Fly   637 MD--REHNETLSKLNFVLALTDCIQEVADSRCAPLSTFMVAGSQSAAQAASADAQQIPPHAPEHC 699
            .|  .|.:|||.|..     .||:.         ..||....:.||....||...::|
Yeast   647 SDDAEEEDETLKKYK-----EDCLS---------TKTFGKGRTLSATSQLSATFNKLP------- 690

  Fly   700 KRA-------ERLVLLVRGLQLLSSGMNLASQQLSNGQLKPSSNVKNALL--------------- 742
             |:       |.:||.::.|.:||..|.:.|......|.|..|...|.|:
Yeast   691 -RSEMILLCNEAIVLYMKALSILSKSMQVTSNWWYESQEKSCSLRVNVLVQWLREKFNECLEKAD 754

  Fly   743 -------TMNAKYRSMLFESKRLNGSGLLQKANAFNITADKILYDYALDMCQAAALDELL-KNTK 799
                   .:..|:.|.:.|::.|...|..::.    :..:|:|||.||::.:.||..||. :|..
Yeast   755 FLRLKINDLRFKHASEVAENQTLEEKGSSEEP----VYLEKLLYDRALEISKMAAHMELKGENLY 815

  Fly   800 NCFERYNTAHILLHSLVQ-------------------KCNHPQDK------------MMLNKYRD 833
            ||...|.|:..:|.:.:.                   |.|..:||            :::.||.|
Yeast   816 NCELAYATSLWMLETSLDDDDFTNAYGDYPFKTNIHLKSNDVEDKEKYHSVLDENDRIIIRKYID 880

  Fly   834 AVEKRLSILQQ 844
            ::..||.||:|
Yeast   881 SIANRLKILRQ 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	116/313 (37%)
		STKc_ULK1_2-like	15..273	CDD:271022	115/306 (38%)
		DUF3543	638..844	CDD:288883	61/268 (23%)
ATG1	NP_011335.1	STKc_ATG1_ULK_like	30..324	CDD:270911	115/306 (38%)
ATG1	NP_011335.1	DUF3543	586..893	CDD:403327	74/348 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I809
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I838
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46828
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24348
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	1	1.000	-	-		X1024
TreeFam	0	0.000	Not matched by this tool.
	9	8.990