Protein Alignment Atg1 and ULK1

DIOPT Version :10

• Sequence 1: NP_001163433.1
• Gene: Atg1 / 39454
• FlyBaseID: FBgn0260945
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: XP_011537100.1
• Gene: ULK1 / 8408
• HGNCID: 12558
• Length: 1073
• Species: Homo sapiens
• Alignment Length: 1136
• Identity: 368/1136 - (32%)
• Similarity: 478/1136 - (42%)
• Gaps: 376/1136 - (33%)

  Fly     4 VGEYEYSSKDMLGHGAFAVVYKGRHRKKH-MPVAIKCITKKGQLKTQNLLGKEIKILKELTELHH 67
            ||::|:|.||::||||||||:|||||:|| :.||:|||.||...|:|.||||||||||   ||.|
Human    11 VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILK---ELKH 72

  Fly    68 ENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHR 132
            ||:|||.|.:|..:.|.|||||||||||||||....||||||:||||.|:||||:.|::|||:||
Human    73 ENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHR 137

  Fly   133 DLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSK 197
            ||||||||||:..|:. ..|:.|.:|||||||||:|....|||||||||||||||||||..||.|
Human   138 DLKPQNILLSNPAGRR-ANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGK 201

  Fly   198 ADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNSKDR 262
            |||||:||||||||||||||.|.:|.:|:.:||:|..|.|.||...|..||.|||.||:||.|||
Human   202 ADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDR 266

  Fly   263 ISYESFFVHRFLQGKKAAVSPGEPSQAANLRRRVSKSGVLPVDMPPLGGTPPAKAKSPLQQQLEQ 327
            :.::.||.|.||.        ..||        |.||..:||...|..|:..:.:.|........
Human   267 MDFDEFFHHPFLD--------ASPS--------VRKSPPVPVPSYPSSGSGSSSSSSSTSHLASP 315

  Fly   328 ELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENNSGSCSSHEDSDDFV 392
            .    .|.|.||.::             .:|:||..|     |.|..|.::.||..|..|:||||
Human   316 P----SLGEMQQLQK-------------TLASPADTA-----GFLHSSRDSGGSKDSSCDTDDFV 358

  Fly   393 LVPKNLPEDQRQGLAQVQAQP-----------ASGGQRPQQQQNQSSPPRPSSLPISEPKPVPAP 446
            :||...|.|........:..|           ||.|.....:....|||..||         |:|
Human   359 MVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSS---------PSP 414

  Fly   447 ARRQVARPGPLTVATLGGQ-------QIPRSQPISVKQPRPDQRKSSVSSDIN------SISPPA 498
            :    .|.||.:.:..|..       |:...|.|......|.|.::..||.::      ..|||.
Human   415 S----GRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAVHRSGRAAEASPPN 475

  Fly   499 VQFAIGTPPTRMRSASGGSL-----SETPPPHA-------------------PST---------- 529
            :.....:...| ||.|...|     |.:||.||                   ||.
Human   476 ICLVFRSSAIR-RSGSTSPLGFARASPSPPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPG 539

  Fly   530 WQVSPGHSQSPLR-----RSGNS------------------------------------------ 547
            |..:|....:.:|     |.|:|
Human   540 WSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAV 604

  Fly   548 ------SPVLPSAAL---------TKL----------PTLGSPTMLV-------APGS---LGSI 577
                  ||..||..|         .||          |.|||||..|       .|.|   |..:
Human   605 FSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALL 669

  Fly   578 GSAGSGSENNNQHHMLGPRAFTLPELGATGGLHS-----------------------------LL 613
            ...|.        .|..||..|||:|...|..|.                             ||
Human   670 ARQGV--------VMTPPRNRTLPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLL 726

  Fly   614 ---------DTG---------------AGGGGEPH------------------------------ 624
                     |.|               ||.||..|
Human   727 KAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQG 791

  Fly   625 -------------------------------------------------------AFQAPELSEE 634
                                                                   .|:||:|.||
Human   792 PRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEE 856

  Fly   635 TLMDREHNETLSKLNFVLALTDCIQEVADSRCAPLSTFMVAGSQSAAQAA---------SADAQQ 690
            |||::||.|.|..|.|.|.....:.|:|            |...||::||         |..|.|
Human   857 TLMEQEHTEILRGLRFTLLFVQHVLEIA------------ALKGSASEAAGGPEYQLQESVVADQ 909

  Fly   691 IPPHAPEHCKRAERLVLLVRGLQLLSSGMNLASQQLSNGQLKPSSNVKNALLTMNAKYR------ 749
            |...:.| ...||:|||.::..:|||||:..|..|:..|:|..||.||..:..:|..|:
Human   910 ISLLSRE-WGFAEQLVLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSC 973

  Fly   750 ---SMLFESKRLNGSGLLQKANAFNITADKILYDYALDMCQAAALDELLKNTKNCFERYNTAHIL 811
               |:..:...|:...||.:.:  :|||:::::.:|:.|.|:|||||:.::.:.|..||:.|.:|
Human   974 QGLSLRLQRFFLDKQRLLDRIH--SITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLL 1036

  Fly   812 LHSLVQKCNHPQDKMMLNKYRDAVEKRLSIL 842
            |..|....:...|...:.|.:..:|:|||.|
Human  1037 LEGLQHMLSDQADIENVTKCKLCIERRLSAL 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	STKc_ULK1_2-like	15..273	CDD:271022	171/258 (66%)
		DUF3543	640..844	CDD:463451	68/221 (31%)
ULK1	XP_011537100.1	STKc_ULK1	13..279	CDD:271104	176/269 (65%)
		DUF3543	860..1067	CDD:463451	67/221 (30%)