DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg1 and Ulk3

DIOPT Version :9

Sequence 1:	NP_001163433.1	Gene:	Atg1 / 39454	FlyBaseID:	FBgn0260945	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_082171.1	Gene:	Ulk3 / 71742	MGIID:	1918992	Length:	472	Species:	Mus musculus

Alignment Length:	429	Identity:	138/429 - (32%)
Similarity:	212/429 - (49%)	Gaps:	46/429 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DMLGHGAFAVVYKGRHRK-KHMPVAIKCITKK--GQLKTQNLLGKEIKILKELTELHHENVVALL 74
            :.||.|.:|.|||...:| ....|||||:.||  .:...:||| .||:|||   .:.|.::|.|.
Mouse    18 ERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLL-TEIEILK---GIRHPHIVQLK 78

  Fly    75 DCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNI 139
            |.:...|.:.|:||:|.||||:.::..:..|.|...|:|:.|||.|::.|:.:.|.|.|||||||
Mouse    79 DFQWDNDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNI 143

  Fly   140 LLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLG 204
            |||     :|..|.   ||:||||||:.::.......|.|||:|||||::...|||::.||||:|
Mouse   144 LLS-----SLEKPH---LKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVG 200

  Fly   205 TIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNSKDRISYESFF 269
            .|:|:.|.|:.||.:::.:||:.....|..:...:...:|.|.||||..||.|:...|||::.||
Mouse   201 VILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPQLSLDCRDLLQRLLERDPARRISFKDFF 265

  Fly   270 VHRFL------------QGKKAAVSPGEPSQAANLRRRVS-KSGVLPVDMPPLGGTPPAKAKSPL 321
            .|.::            |.:...|...:..|..:....:| ....|...:|.|.....|:.|..:
Mouse   266 AHPWVDLEHMPSGESLAQARALVVEAVKKDQEGDAAAALSLYCKALDFFVPALHYEVDAQRKEAI 330

  Fly   322 QQQLEQ------ELKLVKLAEQQQKEREEQEAQEDENTVSVVA--NPAICATITNVGVLCDSENN 378
            :.::.|      |||.:..:..|...|:....||   .:..:|  .|.:.|.:.........|..
Mouse   331 KAKVGQYVSRAEELKAIVSSSNQALLRQGTTVQE---LLREMARDKPRLLAALEVASAALAKEEE 392

  Fly   379 SG------SCSSHEDSDDFVLVPKNLPEDQRQGL-AQVQ 410
            :|      ....|...:..||:....|..:|:.| .:||
Mouse   393 AGKEQDALDLYQHSLGELLVLLAAEAPGRRRELLHTEVQ 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	108/263 (41%)
		STKc_ULK1_2-like	15..273	CDD:271022	108/260 (42%)
		DUF3543	638..844	CDD:288883
Ulk3	NP_082171.1	S_TKc	14..270	CDD:214567	108/263 (41%)
		STKc_ULK3	18..269	CDD:271023	108/262 (41%)
		MIT_2	279..353	CDD:239147	13/73 (18%)
		MIT	374..449	CDD:239121	12/58 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850