DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg1 and Ulk3

DIOPT Version :9

Sequence 1:	NP_001163433.1	Gene:	Atg1 / 39454	FlyBaseID:	FBgn0260945	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001258064.1	Gene:	Ulk3 / 691171	RGDID:	1587417	Length:	472	Species:	Rattus norvegicus

Alignment Length:	436	Identity:	140/436 - (32%)
Similarity:	216/436 - (49%)	Gaps:	59/436 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DMLGHGAFAVVYKGRHRK-KHMPVAIKCITKK--GQLKTQNLLGKEIKILKELTELHHENVVALL 74
            :.||.|.:|.|||...:| ....|||||:.||  .:...:||| .||:|||   .:.|.::|.|.
  Rat    18 ERLGSGTYATVYKAYAKKATREVVAIKCVAKKSLNKASVENLL-TEIEILK---GIRHPHIVQLK 78

  Fly    75 DCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNI 139
            |.:...|.:.|:||:|.||||:.::..:..|.|...|:|:.|||.|::.|:.:.|.|.|||||||
  Rat    79 DFQWDNDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNI 143

  Fly   140 LLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLG 204
            |||     :|..|.   ||:||||||:.::.......|.|||:|||||::...|||::.||||:|
  Rat   144 LLS-----SLEKPH---LKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVG 200

  Fly   205 TIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNSKDRISYESFF 269
            .|:|:.|.|:.||.:::.:||:.....|..:...:...:|.|.||||..||.|:...|||::.||
  Rat   201 VILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPQLSLDCRDLLQRLLERDPSHRISFQDFF 265

  Fly   270 VHRFL------QGKKAAVS------------PGEPSQAANLRRRVSKSGVLPVDMPPLGGTPPAK 316
            .|.::      .|:..|.:            .|:.:.|.:|..:     .|...:|.|.....|:
  Rat   266 AHPWVDLEHMPSGESLAQATALVVEAVKKDQEGDAAAALSLYCK-----ALDFFVPALHYEVDAQ 325

  Fly   317 AKSPLQQQLEQ------ELKLVKLAEQQQKEREEQEAQEDENTVSVVA--NPAICATITNVGVLC 373
            .|..::.::.|      |||.:..:..|...|:....||   .:..:|  .|.:.|.:.......
  Rat   326 RKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGTTGQE---LLREMARDKPRLLAALEVASAAM 387

  Fly   374 DSENNSGSCSSHEDSDDFVLVPKNLPEDQRQGLAQVQAQPASGGQR 419
            ..|..:|     ::.|...|...:|.|     |..:.|..|.|.:|
  Rat   388 AKEEEAG-----KEQDALDLYQHSLGE-----LLLLLAAEAPGRRR 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	108/263 (41%)
		STKc_ULK1_2-like	15..273	CDD:271022	108/260 (42%)
		DUF3543	638..844	CDD:288883
Ulk3	NP_001258064.1	S_TKc	14..270	CDD:214567	108/263 (41%)
		STKc_ULK3	18..269	CDD:271023	108/262 (41%)
		MIT_2	279..353	CDD:239147	13/78 (17%)
		MIT	374..449	CDD:294211	13/60 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820