DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg1 and ulk1b

DIOPT Version :9

Sequence 1:	NP_001163433.1	Gene:	Atg1 / 39454	FlyBaseID:	FBgn0260945	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_002665971.2	Gene:	ulk1b / 558848	ZFINID:	ZDB-GENE-071203-2	Length:	1011	Species:	Danio rerio

Alignment Length:	1075	Identity:	368/1075 - (34%)
Similarity:	489/1075 - (45%)	Gaps:	301/1075 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNIVGEYEYSSKDMLGHGAFAVVYKGRHRKKH-MPVAIKCITKKGQLKTQNLLGKEIKILKELTE 64
            |..||::|:|.||::||||||||:|||||:|| ..||:|||.||...|:|.||||||||||   |
Zfish     1 METVGKFEFSRKDLIGHGAFAVVFKGRHREKHEWEVAVKCINKKNLAKSQTLLGKEIKILK---E 62

  Fly    65 LHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGI 129
            |.|||:|||.|.:|:...|.|||||||||||||||..||||||||:|:||.|:.|||:.|..|||
Zfish    63 LKHENIVALHDFQETASSVYLVMEYCNGGDLADYLHSKGTLSEDTIRVFLQQITGAMRVLQAKGI 127

  Fly   130 VHRDLKPQNILLSHNYGKTLPAPSK-----ITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVI 189
            :|||||||||||||      ||..|     ..:|||||||||:|....|||||||||||||||||
Zfish   128 IHRDLKPQNILLSH------PAGRKSHFNNTCIKIADFGFARYLQNNMMAATLCGSPMYMAPEVI 186

  Fly   190 MSLQYDSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCL 254
            ||..||:||||||:||||:|||||||||.|.:|.:|:.:||:|..|:|.||...|..||.|||.|
Zfish   187 MSQNYDAKADLWSIGTIVFQCLTGKAPFQASSPQDLRLFYEKNKTLSPNIPRETSTHLRHLLLGL 251

  Fly   255 LRRNSKDRISYESFFVHRFLQGKKAAVSPGEPSQAANLRRRVSKSGVLPVDMPPLGGTPPAKAKS 319
            |:||.|||:.::.||.|.||:...:                :.||..:.|...|...:..:.:.|
Zfish   252 LQRNHKDRMDFDEFFRHPFLEASSS----------------MKKSTPVTVTCFPNSASASSCSSS 300

  Fly   320 PLQQQLEQELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVG-VLCDSENNSGSCS 383
            ....          ||...|...|.|..:     ...:|:|    |..:.| :|.||....|..|
Zfish   301 STSH----------LASPPQSLAEIQHVR-----AKALASP----TQDSPGYLLKDSGGGGGGSS 346

  Fly   384 SHE---DSDDFVLVPKNLPED-----------QRQGLAQVQAQPASGGQRPQQQQNQSSPPRPSS 434
            |..   |:||||:||.:.|.:           |...:....:..|||||..|.:    :|||..|
Zfish   347 SKNSSCDTDDFVMVPAHFPSELTCDMPTGKVLQDSLMYSGSSLLASGGQCSQGK----TPPRSPS 407

  Fly   435 LPISEPKPVPAPARRQVARPGPLTVATLG--GQQIPRSQPISVK----------------QPRPD 481
            ...|     |.|:    .||...:.::.|  ||.:|...|..:.                .||..
Zfish   408 FSSS-----PGPS----GRPSEFSGSSYGNYGQSVPIPVPTQIHNYQRMEQNFQFPGQEGSPRSG 463

  Fly   482 --QRKSS---VSSDINSISPPAVQFAI--------GTPPTRMRSASGGSLSETPPPHAPSTWQVS 533
              ||.||   ::......|||....|:        |:.|.:: |...|::.|.|....|::.:|
Zfish   464 LAQRCSSGSFLACGRTGPSPPRSGSAVMSRRLSTGGSKPFQL-SPQVGTIPELPGQVCPASAEV- 526

  Fly   534 PGHSQSPLRRSG---------------NSSPVLPSAA---------------------------- 555
             ||..|   |.|               ||:|.|..||
Zfish   527 -GHRGS---RGGEAKTWPQQQGLGTRLNSAPCLLEAAGGCRQKIRKQHSDPVVAPQANVMPFRTL 587

  Fly   556 -----------LTKLPT-LGSPTMLVAP------------------------------------- 571
                       ...||| ||||:..:.|
Zfish   588 HSSPRLSELMQRNPLPTILGSPSRAMPPFEFPKPPSSPNMVTFLTQQGLRTAQGEPSYSPAYQPE 652

  Fly   572 -----------GSL----------GSIGSAGSGSENNNQHHMLGPRA------------------ 597
                       |.|          |..|..|| .||.|....:...|
Zfish   653 ERKGFGRSQSAGRLSDVLLMAAFGGQRGERGS-MENLNTDRAIDITAPPGGGGIVVGSGSPARVV 716

  Fly   598 FTL--PELGAT---------------------GGLHSLLDTGAG-------GGGEPH-------- 624
            ||:  |..|||                     |.|.|.. |.||       |...|.
Zfish   717 FTIGSPPSGATPPQNSRSRKLSAGSSSSVSPVGSLTSRY-TQAGNYMDCYEGSSSPRYGFSDPIS 780

  Fly   625 --AFQAPELSEETLMDREHNETLSKLNFVLALTDCIQEVADSRCAPLSTFMVAGSQSAAQAASAD 687
              .|:||||.|||||::||.|||.:|.|:|....|:.|||.:|...::...:: |.|..|..|..
Zfish   781 AVTFEAPELPEETLMEQEHTETLCRLRFMLDFARCMVEVAGARSGEMAQTELS-STSLLQQQSLM 844

  Fly   688 AQQIPPHAPEHCKRAERLVLLVRGLQLLSSGMNLASQQLSNGQLKPSSNVKNALLTMNAKYRSML 752
            |.||...:.| ...||:|||.::..:||||.:..|.:.:..|:|.|||.||..:..:|..|:|.:
Zfish   845 ADQISSLSRE-WSYAEQLVLYMKTAELLSSSLQTAMEGIKQGKLYPSSTVKQVVRRLNDLYKSSV 908

  Fly   753 FESKRLNGS---------GLLQKANAFNITADKILYDYALDMCQAAALDELLKNTKNCFERYNTA 808
            ...:.|:..         .|:...|  :|||:::|:.:.:.|.|||||||:....:...:||:.|
Zfish   909 MSCRSLSNQLERFFTRKHKLMDHIN--SITAERLLFGHTVQMVQAAALDEMFHQGEASIQRYHKA 971

  Fly   809 HILLHSLVQKCNHPQDKMMLNKYRDAVEKRLSILQ 843
            .:|:..|........|.:.::|.:..:|:||:.||
Zfish   972 LLLMEGLSLLLTEQADILSISKCKQCIERRLTALQ 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	174/270 (64%)
		STKc_ULK1_2-like	15..273	CDD:271022	171/263 (65%)
		DUF3543	638..844	CDD:288883	68/215 (32%)
ulk1b	XP_002665971.2	PKc_like	6..272	CDD:304357	176/274 (64%)
		S_TKc	9..271	CDD:214567	174/270 (64%)
		DUF3543	796..1007	CDD:288883	68/215 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577624
Domainoid	1	1.000	344	1.000	Domainoid score	I1031
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1458
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	1	1.000	-	-		FOG0002616
OrthoInspector	1	1.000	-	-		otm24383
orthoMCL	1	0.900	-	-		OOG6_104561
Panther	1	1.100	-	-	O	PTHR24348
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	1	1.000	-	-		X1024
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790