DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg1 and stk35l

DIOPT Version :9

Sequence 1:	NP_001163433.1	Gene:	Atg1 / 39454	FlyBaseID:	FBgn0260945	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001008627.1	Gene:	stk35l / 494084	ZFINID:	ZDB-GENE-041212-52	Length:	397	Species:	Danio rerio

Alignment Length:	336	Identity:	101/336 - (30%)
Similarity:	142/336 - (42%)	Gaps:	97/336 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YSSKDMLGHGAFAVVYKGRHRKKHMPVAIKCITKKGQLKTQNLLGKEIKILKELTELHHENVVAL 73
            ||....:|.|::.|||:...||....||:|.:........:..|. |...|..| |..|||||.|
Zfish    60 YSLLREVGRGSYGVVYEAIARKSGAKVAVKKLRCDAPENVELALA-EFWALTSL-EKRHENVVQL 122

  Fly    74 LDC---------------KESQDCVSL----------------------VMEYCNGGDLADYLSV 101
            .:|               |.|:..:.|                      |||:|.||||..::
Zfish   123 EECVLQKNGMAQKMSHGNKRSKQYLRLVETSLKGERVLSCPDEPCYLWFVMEFCEGGDLNQFI-- 185

  Fly   102 KGTLSED----TVRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYGKTLPAPSKITLKIADF 162
               ||..    |...|::||:.|:..|:...||||||||.|||:|.:.|    ||   .||:|||
Zfish   186 ---LSRQPDPHTNASFMMQLSSAVAFLHQNNIVHRDLKPDNILISESSG----AP---VLKVADF 240

  Fly   163 GFARF---LNEGAMAA--------------------TLCGSPMYMAPEVIMSLQYDSKADLWSLG 204
            |.::.   |:.|...|                    :.|||..|||||| ....|.:|||:::||
Zfish   241 GLSKVCAGLSAGVRDAEEGLDKNRNGVVNINKFWLSSACGSDFYMAPEV-WEGHYTAKADIFALG 304

  Fly   205 TIVYQCLTGKAPFYAQTPNE-LKSYYEQNANLAP-------------KIP----SGVSPDLRDLL 251
            .|::..:.......|::..| |.:|..|.:::.|             .||    |.:|..||.||
Zfish   305 IIIWAMIERITFIDAESKRELLGTYVRQGSDIVPVGEALLENPKMVLSIPQRRRSHMSEALRKLL 369

  Fly   252 LCLLRRNSKDR 262
            ..:|..|.:||
Zfish   370 KDMLAVNPQDR 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	101/336 (30%)
		STKc_ULK1_2-like	15..273	CDD:271022	99/330 (30%)
		DUF3543	638..844	CDD:288883
stk35l	NP_001008627.1	PKc_like	59..392	CDD:304357	101/336 (30%)
stk35l	NP_001008627.1	S_TKc	60..388	CDD:214567	101/336 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810