Protein Alignment Atg1 and Ulk1

DIOPT Version :9

• Sequence 1: NP_001163433.1
• Gene: Atg1 / 39454
• FlyBaseID: FBgn0260945
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: XP_006249627.1
• Gene: Ulk1 / 360827
• RGDID: 1589743
• Length: 1057
• Species: Rattus norvegicus
• Alignment Length: 1113
• Identity: 370/1113 - (33%)
• Similarity: 482/1113 - (43%)
• Gaps: 346/1113 - (31%)

  Fly     4 VGEYEYSSKDMLGHGAFAVVYKGRHRKKH-MPVAIKCITKKGQLKTQNLLGKEIKILKELTELHH 67
            ||::|:|.||::||||||||:|||||:|| :.||:|||.||...|:|.||||||||||   ||.|
  Rat    11 VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILK---ELKH 72

  Fly    68 ENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHR 132
            ||:|||.|.:|..:.|.|||||||||||||||....|||||||||||.|:||||:.|::|||:||
  Rat    73 ENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMQLLHSKGIIHR 137

  Fly   133 DLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSK 197
            |||||||||| |.|.....||.|.:|||||||||:|....|||||||||||||||||||..||.|
  Rat   138 DLKPQNILLS-NPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGK 201

  Fly   198 ADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNSKDR 262
            |||||:||||||||||||||.|.:|.:|:.:||:|..|.|.||...|..||.|||.||:||.|||
  Rat   202 ADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLLLALLQRNHKDR 266

  Fly   263 ISYESFFVHRFLQGKKAAVSPGEPSQAANLRRRVSKSGVLPVDMPPLGGTPPAKAKSPLQQQLEQ 327
            :.::.||.|.||.    |.:|            :.||..:||...|..|:..:.:.|........
  Rat   267 MDFDEFFHHPFLD----ASTP------------IKKSPPVPVPSYPSSGSGSSSSSSSASHLASP 315

  Fly   328 ELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENNSGSCSSHEDSDDFV 392
            .    .|.|..|.::             .:.:||..|     |.|..|.::.||.....|:||||
  Rat   316 P----SLGEMPQLQK-------------TLTSPADAA-----GFLQGSRDSGGSSKDSCDTDDFV 358

  Fly   393 LVPKNLPEDQRQGLAQVQAQP----------------ASGGQRPQQQQNQSSPPRPSSLP----- 436
            :||...|.|.....|..:..|                .|.|:.|......||.|.||..|
  Rat   359 MVPAQFPGDLVPEAASAKPPPDSLLCSGSSLVASAGLESHGRTPSPSPTCSSSPSPSGRPGPFSS 423

  Fly   437 ----ISEPKPVP--------------APARRQVAR------------------------------ 453
                .|.|.|||              :|.::|.||
  Rat   424 NRYGASVPIPVPTQVHNYQRIEQNLQSPTQQQTARSSAIRRSGSTSPLGFGRASPSPPSHTDGAM 488

  Fly   454 --------------PGP-----LTVATL----GGQQIPRSQPISVKQPRPDQRKSSVS------- 488
                          |.|     |.|.|:    ...::|..|...|:..|..:..|||.
  Rat   489 LARKLSLGGGRPYTPSPQATLFLPVGTIPERPSWSRVPSPQGADVRAGRSPRPGSSVPEHSPRTT 553

  Fly   489 ------------SDIN----------------SISPP---------------------------- 497
                        ||.:                :.|||
  Rat   554 GLGCRLHSAPNLSDFHVVRPKLPKPPTDPLGATFSPPQTSAPQPCPGLQSCRPLRGSPKLPDFLQ 618

  Fly   498 ---------------------------------AVQFAIGTPP---------------------- 507
                                             |.|..:.|||
  Rat   619 RSPLPPILGSPTKAGPSFDFPKAPSSQSLLTLLARQGVVMTPPRNRTLPDLSEAGPFQGQQLGSG 683

  Fly   508 ------TR----------------MRSASG---------GSLSETPPPHAPSTWQVSPGHSQSPL 541
                  ||                :::|.|         .||.|.|...|||   ...|.:..|.
  Rat   684 LRPAEDTRGPFGRSFSTSRLTDLLLKAAFGTQASDSGSTDSLQEKPMEIAPS---AGFGGTLHPG 745

  Fly   542 RRSGNSSPVLPSAALTKLPTLGSP-----------TMLVAPGSLGSIGSAGSGSENNNQHHMLGP 595
            .|:|.:|...|...     |:|||           |.:.:.||..|:||.||.|    ..|::..
  Rat   746 ARAGGASSPAPVVF-----TVGSPPSGTTPPQSTRTRMFSVGSSSSLGSTGSSS----ARHLVPG 801

  Fly   596 RAFTLPELGATGGLHSLLDTGAGGGGEPHAFQAPELSEETLMDREHNETLSKLNFVLALTDCIQE 660
            .....|||.|.|...||.|..|........|:||:|.|||||::||.|||..|.|.||....:.|
  Rat   802 ACAEAPELSAPGYCCSLADPLAANLEGAVTFEAPDLPEETLMEQEHTETLHSLRFTLAFAQQVLE 866

  Fly   661 VADSRCAPLSTFMVAGSQSAAQAA---------SADAQQIPPHAPEHCKRAERLVLLVRGLQLLS 716
            :|            |...||::||         |..|.||...:.| ...||:|||.::..:|||
  Rat   867 IA------------ALKGSASEAAGGPEYQLQESVVADQISQLSRE-WGFAEQLVLYLKVAELLS 918

  Fly   717 SGMNLASQQLSNGQLKPSSNVKNALLTMNAKYRSMLFESKRLNGSGLLQKANAF----------- 770
            ||:..|..|:..|:|..||.||..:..:|..|::.:     ::..||..:...|
  Rat   919 SGLQTAIDQIRAGKLCLSSTVKQVVRRLNELYKASV-----VSCQGLSLRLQRFFLDKQRLLDGI 978

  Fly   771 -NITADKILYDYALDMCQAAALDELLKNTKNCFERYNTAHILLHSLVQKCNHPQDKMMLNKYRDA 834
             .:||::::..:|:.|.|:|||||:.::.::|..||:.|.:||..|........|...:.|.:..
  Rat   979 HGVTAERLILSHAVQMVQSAALDEMFQHRESCVPRYHKALLLLEGLQHTLTDQADIENIAKCKLC 1043

  Fly   835 VEKRLSIL 842
            :|:|||.|
  Rat  1044 IERRLSAL 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	177/265 (67%)
		STKc_ULK1_2-like	15..273	CDD:271022	174/258 (67%)
		DUF3543	638..844	CDD:288883	68/226 (30%)
Ulk1	XP_006249627.1	STKc_ULK1	13..279	CDD:271104	179/269 (67%)
		S_TKc	16..278	CDD:214567	177/265 (67%)
		DUF3543	844..1051	CDD:288883	67/224 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338206
Domainoid	1	1.000	347	1.000	Domainoid score	I1007
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I1356
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	1	1.000	-	-		FOG0002616
OrthoInspector	1	1.000	-	-		otm46344
orthoMCL	1	0.900	-	-		OOG6_104561
Panther	1	1.100	-	-	O	PTHR24348
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1024
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760