Protein Alignment Atg1 and Ulk2

DIOPT Version :10

• Sequence 1: NP_001163433.1
• Gene: Atg1 / 39454
• FlyBaseID: FBgn0260945
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: XP_063125079.1
• Gene: Ulk2 / 303206
• RGDID: 1310181
• Length: 1082
• Species: Rattus norvegicus
• Alignment Length: 1099
• Identity: 355/1099 - (32%)
• Similarity: 488/1099 - (44%)
• Gaps: 350/1099 - (31%)

  Fly     1 MNIVGEYEYSSKDMLGHGAFAVVYKGRHRKK-HMPVAIKCITKKGQLKTQNLLGKEIKILKELTE 64
            |.:||::|||.:|::||||||||::||||:| ...||||.|.||...|:|.||||||||||   |
  Rat     1 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILK---E 62

  Fly    65 LHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGI 129
            |.|||:|||.|.:|..:.|.|||||||||||||||..||||||||:|:||.|:|.||:.|::|||
  Rat    63 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGI 127

  Fly   130 VHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQY 194
            :||||||||||||: ..:.....|.|.:|||||||||:|:...|||||||||||||||||||..|
  Rat   128 IHRDLKPQNILLSY-ASRRKSNVSGIRIKIADFGFARYLHSNTMAATLCGSPMYMAPEVIMSQHY 191

  Fly   195 DSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNS 259
            |:||||||:||::||||.||.||.|.:|.:|:.:||:|.:|.|.||...||.|.:|||.||:||.
  Rat   192 DAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQ 256

  Fly   260 KDRISYESFFVHRFLQGKKAAVSPGEPSQAANLRRRVSKSGVLPVDMPPLGG---------TPPA 315
            |||:.:|:||.|.||:                 :..|.||  .||.:|...|         :||.
  Rat   257 KDRMDFEAFFSHPFLE-----------------QVPVRKS--CPVPVPVYSGPGPGSSCSSSPPC 302

  Fly   316 KAKSPLQQQLEQELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENNSG 380
            :..||           ..|.:.|.        .::||..|....|.....::.     ||.:||.
  Rat   303 RFASP-----------PSLPDMQH--------IQEENLSSPPLGPPNYLQVSK-----DSASNSS 343

  Fly   381 SCSSHEDSDDFVLVPKNLPEDQR----QGLAQVQAQP---ASGGQRPQQQQNQSSPPRPSSLPIS 438
            ..||. |:|||||||.|:..|..    .|.|..:|..   ..|||           .:|:..|.|
  Rat   344 KNSSC-DTDDFVLVPHNISSDHSYDMPMGTAGRRASNEFFVCGGQ-----------CQPTVSPHS 396

  Fly   439 EPKPVPAPAR-RQVARPGPLTVATLGGQQIPRSQPISVKQPRPD--------------------- 481
            |..|:|.|.: |...|.....::|......|.|.|.|....|.:
  Rat   397 ETAPIPVPTQVRNYQRIEQNLISTASSGTNPHSSPRSAVVRRSNTSPMGFLRVGSCSPVPADTVQ 461

  Fly   482 ---QRKSSVSSDINSISPPAVQFAIGTPP---------------TRMRSASGGSLSETPPPH--- 525
               :|.|:.||...|.||     .:||.|               .|.|.:||..:.:|..|.
  Rat   462 TGGRRLSTGSSRPYSPSP-----LVGTIPEQFSQCCCGHPQGHEARSRHSSGSPVPQTQSPQSLL 521

  Fly   526 -------APSTWQVSPGHSQSPLRRSGNSSPVLPSAA---------------------------- 555
                   ||:...:.  .::..||:. :|.||.||.|
  Rat   522 LGARLQSAPTLTDIY--QNKQKLRKQ-HSDPVCPSLAGAGYSYSPQPSRPGSLGTSPTKHMGSSP 583

  Fly   556 -------LTKLPT-LGSPTMLVAPGSLGSI-------------GSAGSGSENNN----------- 588
                   .|.||| :||||...||..:...             |.|.|.|::.|
  Rat   584 RSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAESQSKDGNDPRQCSHCLLV 648

  Fly   589 ---------------------------QHHMLGP--------------RAFTLPELGATGGL--- 609
                                       |.|:..|              |...:...||.|.:
  Rat   649 QGSERHRSEQQSKAVFGRSVSTGKLSEQQHVKAPLGGHQGSTDSLNTERPMDVAPAGACGVVLAL 713

  Fly   610 ----------------------------HSLLDT--------GAGGG----------GEPHA--- 625
                                        |.:|.|        .:||.          |.|.|
  Rat   714 PAGTAASARAVLFTVGSPPHSATAPTCTHMVLRTRTTSVGSNSSGGSLCSASGRVCVGSPPAPGF 778

  Fly   626 ------------------------------FQAPELSEETLMDREHNETLSKLNFVLALTDCIQE 660
                                          |:||||.|||||:|||.:||..||.:|..|:|:.:
  Rat   779 GSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNMMLMFTECVLD 843

  Fly   661 VADSR------C-APLSTFMVAGSQSAAQAASADAQQIPPHAPEHCKRAERLVLLVRGLQLLSSG 718
            :...|      | :.:|.:.:..|....|.:...         :...|.|:|||.::..|||::.
  Rat   844 LTAVRGGNPELCTSAVSLYQIQESVVVDQISQLS---------KDWGRVEQLVLYMKAAQLLAAS 899

  Fly   719 MNLASQQLSNGQLKPSSNVKNALLTMNAKYRSMLFESKRLNGSGLLQKANAF------------N 771
            ::||..|:.:|:|.||:.||..:..:|.:|:..:...|:|.     :|.|.|            :
  Rat   900 LHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLT-----EKLNRFFSDKQRFIDEINS 959

  Fly   772 ITADKILYDYALDMCQAAALDELLKNTKNCFERYNTAHILLHSLVQKCNHPQDKMMLNK 830
            :||:|::|:.|::|.|:|||||:.:.|::..:||:.|.:||..|.:....|.|...::|
  Rat   960 VTAEKLIYNCAVEMVQSAALDEMFQQTEDIVQRYHKAALLLEGLSKILQDPADAESVHK 1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	STKc_ULK1_2-like	15..273	CDD:271022	165/258 (64%)
		DUF3543	640..844	CDD:463451	60/210 (29%)
Ulk2	XP_063125079.1	None