DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg1 and ULK3

DIOPT Version :9

Sequence 1:	NP_001163433.1	Gene:	Atg1 / 39454	FlyBaseID:	FBgn0260945	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_005254346.1	Gene:	ULK3 / 25989	HGNCID:	19703	Length:	483	Species:	Homo sapiens

Alignment Length:	341	Identity:	117/341 - (34%)
Similarity:	182/341 - (53%)	Gaps:	43/341 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VAIKCITKK--GQLKTQNLLGKEIKILKELTELHHENVVALLDCKESQDCVSLVMEYCNGGDLAD 97
            |||||:.||  .:...:||| .||:|||   .:.|.::|.|.|.:...|.:.|:||:|.||||:.
Human    52 VAIKCVAKKSLNKASVENLL-TEIEILK---GIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSR 112

  Fly    98 YLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYGKTLPAPSKITLKIADF 162
            ::..:..|.|...|:|:.|||.|::.|:.:.|.|.||||||||||     :|..|.   ||:|||
Human   113 FIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLS-----SLEKPH---LKLADF 169

  Fly   163 GFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLGTIVYQCLTGKAPFYAQTPNELKS 227
            |||:.::.......|.|||:|||||::...|||::.||||:|.|:|:.|.|:.||.:::.:||:.
Human   170 GFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEE 234

  Fly   228 YYEQNANLAPKIPSGVSPDLRDLLLCLLRRNSKDRISYESFFVHRFLQ----------GKKAAV- 281
            ....|..:...:...:|.|.||||..||.|:...|||::.||.|.::.          |:..|:
Human   235 KIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALV 299

  Fly   282 -------SPGEPSQAANLRRRVSKSGVLPVDMPPLGGTPPAKAKSPLQQQLEQ------ELKLVK 333
                   ..|:.:.|.:|..:     .|...:|.|.....|:.|..::.::.|      |||.:.
Human   300 VQAVKKDQEGDSAAALSLYCK-----ALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIV 359

  Fly   334 LAEQQQKEREEQEAQE 349
            .:..|...|:...|::
Human   360 SSSNQALLRQGTSARD 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	100/240 (42%)
		STKc_ULK1_2-like	15..273	CDD:271022	100/239 (42%)
		DUF3543	638..844	CDD:288883
ULK3	XP_005254346.1	S_TKc	46..281	CDD:214567	100/240 (42%)
		STKc_ULK3	46..280	CDD:271023	100/239 (42%)
		MIT_2	290..364	CDD:239147	14/78 (18%)
		MIT	385..460	CDD:294211
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850