DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg1 and unc-51

DIOPT Version :9

Sequence 1:	NP_001163433.1	Gene:	Atg1 / 39454	FlyBaseID:	FBgn0260945	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_507869.1	Gene:	unc-51 / 180311	WormBaseID:	WBGene00006786	Length:	856	Species:	Caenorhabditis elegans

Alignment Length:	925	Identity:	347/925 - (37%)
Similarity:	484/925 - (52%)	Gaps:	163/925 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YEYSSKDMLGHGAFAVVYKGRH-RKKHMPVAIKCITKKGQLKTQNLLGKEIKILKELTELHHENV 70
            :|||.:|:|||||||:||:||: .:..:|||||.|.||...|::|||.|||||||||:.|.|||:
Worm     7 FEYSKRDLLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNISKSKNLLTKEIKILKELSSLKHENL 71

  Fly    71 VALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLK 135
            |.||.|.|:...|.||||:||||||||||..|.||:|||::.|:||:|.|::|:..|||||||||
Worm    72 VGLLKCTETPTHVYLVMEFCNGGDLADYLQQKTTLNEDTIQHFVVQIAHALEAINKKGIVHRDLK 136

  Fly   136 PQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADL 200
            ||||||.:|.....|..:.|.:|:||||||||||:|.|||||||||||||||||||:|||:||||
Worm   137 PQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMAATLCGSPMYMAPEVIMSMQYDAKADL 201

  Fly   201 WSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNSKDRISY 265
            ||:|||::|||||||||.||||.:||:|||:...|.|.||...||:||||||.||:||:|||||:
Worm   202 WSIGTILFQCLTGKAPFVAQTPPQLKAYYEKTRELRPNIPEWCSPNLRDLLLRLLKRNAKDRISF 266

  Fly   266 ESFFVHRFLQGKKAAVSPGEPSQAANL-----------RRRVSKSGVLPVDMPPLGGTPPAKAKS 319
            |.||.|.||      .||..||.:..:           ||.::....|||  |...|:....:.:
Worm   267 EDFFNHPFL------TSPLLPSPSKRILESARSPLLANRRIITPQSSLPV--PKRAGSTKLDSPT 323

  Fly   320 PLQQQLEQELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENNSGSCSS 384
            |::          ::.|..:.:|.             |..|.:.:.:....:
Worm   324 PVR----------RIGESPRVQRR-------------VITPGMPSPVPGAPM------------- 352

  Fly   385 HEDSDDFVLVPKNLPEDQRQGLAQVQAQPASGGQRPQQQQNQSSPPRPSSLPISEPKPVPA---- 445
             ::|.||..:|   |..:...:.|||.            ....||    ||...:|.|||:
Worm   353 -QESTDFTFLP---PRQESSPVKQVQV------------HTNVSP----SLTTCKPVPVPSQRLT 397

  Fly   446 --------PARRQVARP---GPLTVATLG-------GQQIPRSQPISVKQPRPDQ--RKSSV--- 487
                    .|.|:.|.|   .|...|...       .||.|.|.|:..:..||||  |::::
Worm   398 YQKMEERLAAARKTAVPSSSSPTGSAVSAQHQHQHQQQQEPASSPVVQRIERPDQLPRRTTLQDP 462

  Fly   488 -SSDINSISPPAVQFAI---GTPPT-----RMRS-------------ASGGSLSETPP------- 523
             :.||..::.|...|.:   .|.|:     |:|.             |:...||...|
Worm   463 NAHDIERMTMPNPTFVVCGSSTKPSPNNANRVRRSTITSPADTQDMVAADQMLSNLDPTTTTTTI 527

  Fly   524 PHAPSTWQVSPGHSQSPLRRSGNSSP--------VLPSAALTKLPTLGSPTMLVAPGSLGSIGSA 580
            |.:.:|..:. |..:....||..|.|        .|.:|...:.....|||....|..:.:..:.
Worm   528 PKSATTANIQ-GIPRGARDRSVTSPPQPTIHENEPLDNAKYQQTDVNNSPTAPTEPFIIKNQTTC 591

  Fly   581 GSGSENNNQHHMLGPRAFTLPELGATGGLHSLLDTGAGGGGEP------HAFQAPELSEETLMDR 639
            .:.|.:::.  :....|.:||   ...|.|    ..||....|      |....|.|.:|.::..
Worm   592 STSSTSSSV--VEEEEAMSLP---FASGSH----LAAGFKKTPAEVPMDHGALPPALDQEIVLGE 647

  Fly   640 EHNETLSKLNFVLALTDCIQEVADSRCAPLSTFMVAGSQSAAQAASADAQQIPPHAPEHCKRAER 704
            ||.:.|:||.||..|.|.:..||:.:..||::.|.:..|......|......|      .:|||:
Worm   648 EHKQILAKLRFVAELVDTLIHVAEQKDNPLASAMASRRQLLTTGTSTTNTSSP------YRRAEQ 706

  Fly   705 LVLLVRGLQLLSSGMNLASQQLSNGQLKPSSNVKNALLTMNAKYRSMLFESKRLNGSGLLQKANA 769
            ||:.||.|.:|||.:.||...::|..|.||..|:..|..:|.||...|..|:.|...||..:..|
Worm   707 LVVYVRALHMLSSALLLAQTNVANRVLHPSVAVQQVLNQLNDKYHQCLVRSQELASLGLPGQDPA 771

  Fly   770 FN-ITADKILYDYALDMCQAAALDELLKNTKNCFERYNTAHILLHSLVQKCNHPQDKMMLNKYRD 833
            .. |:|::|:|.:|:::|||||||||..|.:.|.:||.||:::||:|.::.|..|||.:|.:|:.
Worm   772 MAVISAERIMYRHAIELCQAAALDELFGNPQLCSQRYQTAYMMLHTLAEQVNCDQDKTVLTRYKV 836

  Fly   834 AVEKRLSILQQHGYI 848
            ||||||.||::.|::
Worm   837 AVEKRLRILERQGFV 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	175/265 (66%)
		STKc_ULK1_2-like	15..273	CDD:271022	172/258 (67%)
		DUF3543	638..844	CDD:288883	82/206 (40%)
unc-51	NP_507869.1	S_TKc	9..275	CDD:214567	175/265 (66%)
		STKc_ULK1_2-like	15..274	CDD:271022	172/258 (67%)
		DUF3543	647..848	CDD:288883	82/206 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159011
Domainoid	1	1.000	354	1.000	Domainoid score	I521
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	486	1.000	Inparanoid score	I789
Isobase	1	0.950	-	0	Normalized mean entropy	S3689
OMA	1	1.010	-	-		QHG28724
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	1	1.000	-	-		FOG0002616
OrthoInspector	1	1.000	-	-		oto17187
orthoMCL	1	0.900	-	-		OOG6_104561
Panther	1	1.100	-	-	LDO	PTHR24348
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	1	1.000	-	-		X1024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.880