Protein Alignment Atg1 and CSK

DIOPT Version :10

• Sequence 1: NP_001163433.1
• Gene: Atg1 / 39454
• FlyBaseID: FBgn0260945
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_004374.1
• Gene: CSK / 1445
• HGNCID: 2444
• Length: 450
• Species: Homo sapiens
• Alignment Length: 240
• Identity: 69/240 - (28%)
• Similarity: 111/240 - (46%)
• Gaps: 36/240 - (15%)

  Fly    15 LGHGAFAVVYKGRHRKKHMPVAIKCITKKGQLKTQNLLGKEIKILKELTELHHENVVALLD-CKE 78
            :|.|.|..|..|.:|..  .||:|||  |.....|..|.:    ...:|:|.|.|:|.||. ..|
Human   201 IGKGEFGDVMLGDYRGN--KVAVKCI--KNDATAQAFLAE----ASVMTQLRHSNLVQLLGVIVE 257

  Fly    79 SQDCVSLVMEYCNGGDLADYLSVKG--TLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNILL 141
            .:..:.:|.||...|.|.|||..:|  .|..|.:..|.:.:..||:.|.....|||||..:|:|:
Human   258 EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV 322

  Fly   142 SHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPM-YMAPEVIMSLQYDSKADLWSLGT 205
            |.:.          ..|::|||..:   |.:........|: :.|||.:...::.:|:|:||.|.
Human   323 SEDN----------VAKVSDFGLTK---EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI 374

  Fly   206 IVYQCLT-GKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRD 249
            ::::..: |:.| |.:.|  ||       ::.|::..|...|..|
Human   375 LLWEIYSFGRVP-YPRIP--LK-------DVVPRVEKGYKMDAPD 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	STKc_ULK1_2-like	15..273	CDD:271022	69/240 (29%)
		DUF3543	640..844	CDD:463451
CSK	NP_004374.1	Interaction with PTPN22. /evidence=ECO:0000250|UniProtKB:P41241	9..70
		SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190
		PTKc_Csk	188..443	CDD:133213	69/240 (29%)