Protein Alignment Atg1 and ulk2

DIOPT Version :10

• Sequence 1: NP_001163433.1
• Gene: Atg1 / 39454
• FlyBaseID: FBgn0260945
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: XP_004911684.1
• Gene: ulk2 / 100487396
• XenbaseID: XB-GENE-6041491
• Length: 1073
• Species: Xenopus tropicalis
• Alignment Length: 1136
• Identity: 373/1136 - (32%)
• Similarity: 491/1136 - (43%)
• Gaps: 366/1136 - (32%)

  Fly     1 MNIVGEYEYSSKDMLGHGAFAVVYKGRHRKK-HMPVAIKCITKKGQLKTQNLLGKEIKILKELTE 64
            |.:||::|||.||::||||||||:||||||| ...||||.|.||...|:|.||||||||||   |
 Frog     1 MEVVGDFEYSRKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQILLGKEIKILK---E 62

  Fly    65 LHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGI 129
            |.|||:|||.|.:|..:.|.||||:||||||||||..||||||||:|:||.|:|.||:.|::|||
 Frog    63 LQHENIVALYDVQEMPNSVFLVMEFCNGGDLADYLQAKGTLSEDTIRIFLQQIAAAMRVLHSKGI 127

  Fly   130 VHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQY 194
            :||||||||||||:...|.... |.|.:|||||||||:|....|||||||||||||||||||..|
 Frog   128 IHRDLKPQNILLSYASRKKATF-SGIRIKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHY 191

  Fly   195 DSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNS 259
            |:||||||:||::||||.||.||.|.:|.:|:.:||:|.||.|.||...|..|.||||.||:||.
 Frog   192 DAKADLWSIGTVIYQCLVGKPPFQANSPQDLRLFYEKNKNLVPSIPRETSAYLSDLLLALLQRNQ 256

  Fly   260 KDRISYESFFVHRFLQG----KKAAVSPGEPSQAANLRRRVSKSGVLPVDMPPLGGTPPAKAKSP 320
            |||:.:|.||.|.||..    ||:...|...|..:::      ||      ...|.:|..:..||
 Frog   257 KDRLDFEGFFNHPFLDQVSTVKKSCPVPVPTSSGSSI------SG------SSCGSSPSCRFASP 309

  Fly   321 LQQQLEQELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENNSGSCSSH 385
                       ..|.:.|.        .::||..|....|.....::.......|:|:  ||
 Frog   310 -----------PSLPDMQH--------IQEENLSSPPLGPPNYLQVSKDSASTSSKNS--SC--- 350

  Fly   386 EDSDDFVLVPKNLPEDQRQGLAQVQAQP--------ASGGQRP---------------------- 420
             |:|||||||.|||.|....:....|..        .||||.|
 Frog   351 -DTDDFVLVPHNLPSDHFYDMTTAAAGRRTSSSEFLMSGGQSPLNTSGSMGIVQKPTVNALRCGS 414

  Fly   421 -----QQQQNQSSP-------PRPSSL---------------PISEP--KPVPAPARRQVARPGP 456
                 :|.|.|.||       |.|:.|               |.|.|  .|.....||....|
 Frog   415 SSVTARQGQPQVSPRSETAPIPVPTQLRNYQRIEQNLTTTASPTSNPHGSPRSGAVRRSNTSP-- 477

  Fly   457 LTVATLGGQQIPRSQPISVKQPRP-DQRKSSVSSDINSISPPAVQFAIGTPP------------- 507
                 ||..::....|.|....:. .:|.|:.||...|.||     .:||.|
 Frog   478 -----LGFLKVGSGSPSSADMVQAVGRRLSTGSSRPYSPSP-----LVGTIPEQLGHCCCGYAQG 532

  Fly   508 --TRMRSASGGSLSETPPPHAPSTWQVSPGHSQS------------PLRRSGNSSPVLPSAA--- 555
              :|.|::||||    |.|.:.||..:.....||            .||:. :|.||.||.|
 Frog   533 HESRSRNSSGGS----PVPQSQSTQPLLGARLQSAPTLTDIYQNKQKLRKQ-HSDPVCPSYAGQG 592

  Fly   556 --------------------------------LTKLPT-LGSPTMLVAP---------------- 571
                                            .|.||| :||||...||
 Frog   593 FGHSPQPARPVSLGASPTKHMGSSPRSSEWLYKTPLPTIIGSPTKATAPFKIPKTQASSNLLALV 657

  Fly   572 ----------------------------------------GSLGSIGSAGSGSENNNQ-----HH 591
                                                    .:.|...|||..|:...:     .|
 Frog   658 NRQGPVDTSVPAKDTLEAREFSQFVCTYGTEKQNPLEHGKATFGRSVSAGRLSDQTGRATLGGQH 722

  Fly   592 MLGP-------------------RAFTLPELGATGGL----------------HSLLDT------ 615
            ..|.                   .|.|:|.:|..|.:                |.::.|
 Frog   723 YQGSTDSLNSERPMDTVPAGACGAALTVPLVGNRGVMFTVGSPPNSATPPTCTHMMMRTRTTSVG 787

  Fly   616 --GAGGG----------GEPH---------------------------------AFQAPELSEET 635
              .:||.          |.|.                                 .|:||||.|||
 Frog   788 SNSSGGSLCSTSGRVLMGSPSTFNMGSSPPGADAAPSLKYMSYGTSPPSLEDFITFEAPELPEET 852

  Fly   636 LMDREHNETLSKLNFVLALTDCIQEVADSR------CA-PLSTFMVAGSQSAAQAASADAQQIPP 693
            ||:|||.:||..||.:|..|:|:.|:..:|      || .:|.:.:..|....|.:...
 Frog   853 LMEREHTDTLRHLNLMLMFTECVLELTATRGGNPELCASAVSLYQIQESVVVDQISQLS------ 911

  Fly   694 HAPEHCKRAERLVLLVRGLQLLSSGMNLASQQLSNGQLKPSSNVKNALLTMNAKYRSMLFESKRL 758
               :...:.|:|||.::..|.|:|.:.||..|:..|:|.|||.||..:.:||.:|:..:...|::
 Frog   912 ---KEWGQVEQLVLYMKAAQFLASSLQLAKSQIRAGKLTPSSTVKQVVKSMNERYKFCISMCKKM 973

  Fly   759 NGSGLLQKANAF------------NITADKILYDYALDMCQAAALDELLKNTKNCFERYNTAHIL 811
            .     ::.|.|            ::||:|::|..|:||.|.|||||:...|::...||:.|.:|
 Frog   974 T-----EQLNRFFSDKQRFVDEINSVTAEKLIYSCAVDMVQTAALDEMFHQTEDIAYRYHKAALL 1033

  Fly   812 LHSLVQKCNHPQDKMMLNKYRDAVEKRLSIL 842
            |..|.:....|.|...::||:..||.|||.|
 Frog  1034 LEGLTKVLQSPADIENVHKYKANVESRLSAL 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	STKc_ULK1_2-like	15..273	CDD:271022	168/258 (65%)
		DUF3543	640..844	CDD:463451	69/222 (31%)
ulk2	XP_004911684.1	STKc_ULK2	2..272	CDD:271103	176/273 (64%)
		DUF3543	857..1064	CDD:463451	68/220 (31%)