DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg1 and ulk2

DIOPT Version :9

Sequence 1:	NP_001163433.1	Gene:	Atg1 / 39454	FlyBaseID:	FBgn0260945	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_002664661.3	Gene:	ulk2 / 100329702	ZFINID:	ZDB-GENE-090218-30	Length:	1034	Species:	Danio rerio

Alignment Length:	1109	Identity:	381/1109 - (34%)
Similarity:	500/1109 - (45%)	Gaps:	351/1109 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNIVGEYEYSSKDMLGHGAFAVVYKGRHRKK-HMPVAIKCITKKGQLKTQNLLGKEIKILKELTE 64
            |..||::|||.||::||||||||:||||:|| ...||||.|.||...|:|.||||||||||   |
Zfish     1 METVGDFEYSRKDLIGHGAFAVVFKGRHKKKTDWEVAIKSINKKNLSKSQILLGKEIKILK---E 62

  Fly    65 LHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGI 129
            |.|||:|||.|.:|:...|.|||||||||||||||..||||.|||:|:||.|:|.||:.|.:|||
Zfish    63 LQHENIVALYDVQETPSSVFLVMEYCNGGDLADYLQAKGTLREDTLRVFLQQIAAAMRILNSKGI 127

  Fly   130 VHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQY 194
            :||||||||||||:. |:...:.:.|.:|||||||||:|....|||||||||||||||||||..|
Zfish   128 IHRDLKPQNILLSYT-GRKKSSINGIRIKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQNY 191

  Fly   195 DSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNS 259
            |:||||||:||::||||.||.||.|.:|.:|:.:||:|.:|.|.||...||.|.||||.||:||.
Zfish   192 DAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNKSLVPNIPRETSPQLEDLLLGLLQRNQ 256

  Fly   260 KDRISYESFFVHRFLQGKKAAVSPGEPSQAANLRRRVSKSGVLPVDMP---------PLGGTPPA 315
            ||||.:::||.|.||          ||...      :.||  .||.:|         ..|.:|..
Zfish   257 KDRIDFDTFFSHPFL----------EPIST------IKKS--CPVPVPSCSGLVSDSTCGSSPSC 303

  Fly   316 KAKSPLQQQLEQELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENNSG 380
            :..||                  ....:.|...||     |:::|.:...    ..|..|:.:.|
Zfish   304 RYVSP------------------PSLPDMQTLPED-----VLSSPPLGPP----NYLQLSKESGG 341

  Fly   381 SCSSHE---DSDDFVLVPKNLPEDQRQGL--AQVQAQPAS-----GGQRPQQQQNQSSPPRPSSL 435
            |.||..   |:||||||| :|..:|...|  ..|..:|:|     ||. ||....|:    |...
Zfish   342 STSSKNSSCDTDDFVLVP-HLSGEQSYDLPMGAVGRRPSSEFLLCGGS-PQPSTGQT----PMVS 400

  Fly   436 PISEPKPVPAPAR-------RQVARPGPLTVATLGGQQIPRS--------QPISVKQ-----PRP 480
            |.||..|:|.|.:       :|.....|.|  ||.|.  |||        .|:...:     |.|
Zfish   401 PRSETTPIPVPTQVRNYQRIKQNLSSSPTT--TLYGS--PRSGTVRRSNTSPMGFPKMVSASPSP 461

  Fly   481 -------DQRKSSVSSDINSISPPAVQFAIGTPP---------------TRMRSASGGS------ 517
                   .:|.|:.||...|.||     .:||.|               .|.||:||||
Zfish   462 ADTVQTVGRRLSTGSSRPYSPSP-----LVGTIPEQLGHCCCGHPQSHEPRSRSSSGGSPVPSSQ 521

  Fly   518 -----LSETP------------------PPHAPSTWQVSPGHS----------QSPLRRSGNSSP 549
                 |...|                  |.| |::......||          .||.:..| |||
Zfish   522 LLGARLQSAPTLTDIYQSKQKLHKQLSDPVH-PTSSAYPSNHSPQLGRPANLGTSPTKHLG-SSP 584

  Fly   550 VLPSAALTK--LPT-LGSPTMLVAP-------GSLGSIGSAGSGSENNN--------QHHMLG-- 594
             ..|..|||  ||| :||||.:.||       .|...:..|.|...|..        .||...
Zfish   585 -RTSDWLTKSPLPTIIGSPTKVTAPFKIPKTQASCNLMALADSPIPNKTLMDGRELCAHHCTAYP 648

  Fly   595 --------------------------PRAFTL---PELGATGGLHS--LLDTG-------AGGGG 621
                                      |...||   |..|:|..|::  .:||.       |.|||
Zfish   649 SSRQPAPEASKTSFGRSVSAGRLSEPPVRITLGGQPYQGSTDSLNTERPMDTAPAGMCALAAGGG 713

  Fly   622 EPH-------------------------------------------------------------- 624
            .|.
Zfish   714 SPRTVVFTVGSPPSSSTPPTCSHLASRPRATSVGSNSSAGSLCSTSGKVYMGSPPGMTIGSSPPG 778

  Fly   625 ------------------------AFQAPELSEETLMDREHNETLSKLNFVLALTDCIQEVADSR 665
                                    .|:||||.|||||:|||.:||..|..:|:.|||:.|:|..|
Zfish   779 AEAGPSSLRYVPYGTSPPSLDGFITFEAPELPEETLMEREHTDTLMYLRMMLSFTDCVLEIAALR 843

  Fly   666 CAPLSTFMVAGSQSAAQAASADAQQIPP----------HAPEHCKRAERLVLLVRGLQLLSSGMN 720
                    ..|....|.|||.    .||          .......:.|:|||.::..|||:|.::
Zfish   844 --------AGGPDLGASAASL----YPPQDSVVVDQISQLSREWGQVEQLVLYMKAAQLLASSLH 896

  Fly   721 LASQQLSNGQLKPSSNVKNALLTMNAKYRSMLFESKRLNGSGLLQKANAF------------NIT 773
            ||..|:.:.:|.||:.||..:.::|.:|:|.:...:||.     .|.|.|            ::|
Zfish   897 LAKAQIKSAKLNPSTAVKQVVKSLNERYKSCISLCRRLT-----DKLNHFFSDKQRFVDEINSVT 956

  Fly   774 ADKILYDYALDMCQAAALDELLKNTKNCFERYNTAHILLHSLVQKCNHPQDKMMLNKYRDAVEKR 838
            |:|::|::|::|.|:|||||:.:.|::...|||.|.:||..|.:....|.|...:.||:.:|::|
Zfish   957 AEKLIYNHAVEMVQSAALDEMFQQTEDIAYRYNKASMLLEGLTKILQDPADIENVIKYKASVDRR 1021

  Fly   839 LSIL 842
            :|.|
Zfish  1022 ISAL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	170/265 (64%)
		STKc_ULK1_2-like	15..273	CDD:271022	166/258 (64%)
		DUF3543	638..844	CDD:288883	72/227 (32%)
ulk2	XP_002664661.3	PKc_like	2..272	CDD:304357	175/283 (62%)
		S_TKc	9..271	CDD:214567	170/265 (64%)
		DUF3543	818..1025	CDD:288883	70/223 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577625
Domainoid	1	1.000	344	1.000	Domainoid score	I1031
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1458
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	1	1.000	-	-		FOG0002616
OrthoInspector	1	1.000	-	-		otm24383
orthoMCL	1	0.900	-	-		OOG6_104561
Panther	1	1.100	-	-	LDO	PTHR24348
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.800