Protein Alignment Atg1 and ulk1a

DIOPT Version :9

• Sequence 1: NP_001163433.1
• Gene: Atg1 / 39454
• FlyBaseID: FBgn0260945
• Length: 855
• Species: Drosophila melanogaster
• Sequence 2: NP_001124103.1
• Gene: ulk1a / 100170793
• ZFINID: ZDB-GENE-080723-31
• Length: 927
• Species: Danio rerio
• Alignment Length: 1005
• Identity: 349/1005 - (34%)
• Similarity: 472/1005 - (46%)
• Gaps: 235/1005 - (23%)

  Fly     1 MNIVGEYEYSSKDMLGHGAFAVVYKGRHRKKH-MPVAIKCITKKGQLKTQNLLGKEIKILKELTE 64
            |..:|:||::.||::||||||||:||||::|| ..||:|||.:|...|:|:||||||||||   |
Zfish     1 MESIGKYEFNRKDLIGHGAFAVVFKGRHKQKHNFEVAVKCINRKNLAKSQSLLGKEIKILK---E 62

  Fly    65 LHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGI 129
            |.|||:|:|||.:|...||.||||||||||||:||..||.|||||:|:.|.||||||..|.:|||
Zfish    63 LKHENIVSLLDFQEISGCVYLVMEYCNGGDLAEYLHSKGCLSEDTIRVLLQQLAGAMSVLRSKGI 127

  Fly   130 VHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQY 194
            :||||||||||||::.|:. ..|:.|.:|:|||||||:|....|||||||||||||||||||..|
Zfish   128 IHRDLKPQNILLSYSTGRK-SNPNNICIKLADFGFARYLQGNTMAATLCGSPMYMAPEVIMSHNY 191

  Fly   195 DSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNS 259
            |:||||||:|||:||||||||||.|.||.||:.:||:|.:|:|.||...|..||.|||.||:||.
Zfish   192 DAKADLWSVGTIIYQCLTGKAPFQASTPQELRQFYERNRSLSPSIPRETSSHLRHLLLGLLQRNQ 256

  Fly   260 KDRISYESFFVHRFLQGKKAAVSPGEPSQAANLRRRVSKSGVLPVDMP----PLGGTPPAKAKS- 319
            ::||.::.||.|.||:...:                :.||..:||.:|    |..|:....:.|
Zfish   257 RERIDFDDFFHHPFLEASTS----------------MKKSSPVPVPVPVPTYPSSGSGSFSSGSS 305

  Fly   320 -----PLQQQLEQELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENNS 379
                 |.|...|....|                            |.:..|.:...:|.|
Zfish   306 TSRLTPTQSDTEAPKSL----------------------------PQMKPTESPGSLLKD----- 337

  Fly   380 GSCSSHEDSDDFVLVPKNLPEDQRQGLAQVQAQPA----------SGG----------QRPQQQQ 424
               ||..||||||:||           ||..::|.          ||.          |.|....
Zfish   338 ---SSSSDSDDFVMVP-----------AQFTSEPVGAEGQDSLMRSGSSLLGATACLCQTPSSSP 388

  Fly   425 NQSSPPRP--------SSLPISEPKPVP--------------------APARRQVARPGPLTVAT 461
            :..:.|||        ||...|.|.|||                    |.|....:...|....|
Zfish   389 SGRTSPRPSRHLESCGSSYAQSIPVPVPTQKHNYQRMEHNLQESERTSASAHHCCSDGSPACGRT 453

  Fly   462 -----LGGQQ--IPRSQ----PISVKQPRP----------DQRKSSVS---SDINSISPPAVQ-- 500
                 .||.:  :|..|    |.:..||.|          ||:...||   :|:..:.|...|
Zfish   454 GVSPDSGGSRSYLPSPQVGSIPETPSQPEPVGSRTGFHATDQQPGQVSPLFTDLTDLDPTLAQRL 518

  Fly   501 ----FAIGTPPTRMRSASGGSLSETP-------------------------PPHAPSTWQVSPGH 536
                .::.|...|.......|..:||                         |...|....|.|..
Zfish   519 RAHRHSLDTIVHRWDLCRRPSFGQTPNAALLQRGLTTRTKTMCDLKDLAQYPAAGPRVPLVRPAE 583

  Fly   537 SQSPLRRS---GNSSPVLPSAALTKLPTLGS--------PTMLVAP-----------GSLGSIGS 579
            .:..::||   |..|..|..|........||        |....||           |.:..:|:
Zfish   584 RRDTVKRSVSTGRLSDKLLKAVFGHQLDRGSCESLNSEKPMDTTAPPCGVDRSDSPAGVMFMLGT 648

  Fly   580 AGSGSENNNQHH---MLGPRAFTLPELGATGG-----LHSLLDTGAGGGGEPHAFQAPELSEETL 636
            ...|....:..|   .:|....|.|  |.|.|     |:...|..|....|...|..|||.||||
Zfish   649 PEYGHTPPHARHRRFSVGAPCSTSP--GWTYGSPESLLYGYTDAMATNLHENVTFVPPELPEETL 711

  Fly   637 MDREHNETLSKLNFVLALTDCIQEVADSRCAPLSTFMVAGSQSAAQAASADAQQIPPHAPEHCKR 701
            |:..|.:.||:|.||||.:.||.|:|:::  .:.|.......::....|..|.||...:.| ...
Zfish   712 MEEGHTDLLSQLRFVLAFSHCITELAETK--DIGTGRNVPPNASLLEQSVVADQISLLSRE-WSS 773

  Fly   702 AERLVLLVRGLQLLSSGMNLASQQLSNGQLKPSSNVKNALLTMNAKYRSML-------------F 753
            ||:|||.::..:||||.::.|...:..|:|.||.:||..:..:|..|:..:             |
Zfish   774 AEQLVLYMKCAELLSSALHTAMAGIKEGKLYPSGSVKQVVRELNEMYKECVNSCRSLTEKLQHFF 838

  Fly   754 ESKRLNGSGLLQKANAFNITADKILYDYALDMCQAAALDELLKNTKNCFERYNTAHILLHSLVQK 818
            .||:    .|:.:.|  :|||::::|.:.:.|.|.|||||:..:.::..|||:.|.:|:..|...
Zfish   839 SSKQ----RLMDRMN--SITAERLIYAHTVQMVQTAALDEMFHHGESSLERYHKALLLMEGLSLI 897

  Fly   819 CNHPQDKMMLNKYRDAVEKRLSILQQHGYI 848
            ...|.|...:||.:..:|:||..||..|.:
Zfish   898 ITEPSDLNNVNKCKRCIERRLCSLQAQGCV 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	170/265 (64%)
		STKc_ULK1_2-like	15..273	CDD:271022	168/258 (65%)
		DUF3543	638..844	CDD:288883	66/218 (30%)
ulk1a	NP_001124103.1	STKc_ULK1	6..272	CDD:271104	173/269 (64%)
		S_TKc	9..271	CDD:214567	170/265 (64%)
		DUF3543	713..924	CDD:288883	67/219 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577623
Domainoid	1	1.000	344	1.000	Domainoid score	I1031
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1458
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	1	1.000	-	-		FOG0002616
OrthoInspector	1	1.000	-	-		otm24383
orthoMCL	1	0.900	-	-		OOG6_104561
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1024
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.700