DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg1 and ulk3

DIOPT Version :9

Sequence 1:	NP_001163433.1	Gene:	Atg1 / 39454	FlyBaseID:	FBgn0260945	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_012821384.1	Gene:	ulk3 / 100125204	XenbaseID:	XB-GENE-5958931	Length:	468	Species:	Xenopus tropicalis

Alignment Length:	470	Identity:	150/470 - (31%)
Similarity:	225/470 - (47%)	Gaps:	81/470 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DMLGHGAFAVVYKG-RHRKKHMPVAIKCITKKGQLK--TQNLLGKEIKILKELTELHHENVVALL 74
            :.||.|::|.|||. |.|.....|||||::||...|  .:||| .||:|||   .:||.:::.|.
Frog    17 EKLGSGSYATVYKAYRKRNSREVVAIKCVSKKSLNKAAVENLL-TEIEILK---TVHHPHILELK 77

  Fly    75 DCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNI 139
            |.:..||.:.|:.|||.||||:.::..:..|.|..|::||.|||.|:|.|:...|.|.|||||||
Frog    78 DFQWDQDYIFLITEYCAGGDLSRFIRTRRILPERVVQIFLQQLASALKFLHEGNISHLDLKPQNI 142

  Fly   140 LLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLG 204
            |||.     |..|.   ||:||||||:.::.......|.|||:|||||::.|..||::.||||:|
Frog   143 LLSR-----LDRPH---LKLADFGFAQHMSSDDAPQALRGSPLYMAPEMVCSRHYDARVDLWSVG 199

  Fly   205 TIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNSKDRISYESFF 269
            .|:|:.|.||.||.:::.:||:.....:..:.......:|.:.|:||..||:|:...|||:..||
Frog   200 VILYEALFGKPPFASKSFSELEEKICSHKTIELPTRPRLSSECRNLLQRLLQRDPDKRISFVEFF 264

  Fly   270 VHRFL------------QGKKAAV------SPGEPSQAANLRRRVSKSGVLPVDMPPLGGTPPAK 316
            .|.|:            :..:..|      |.||.|.|..|..|     .|...:|.|......:
Frog   265 THPFVDLEHMPSAESLEKATRLVVEAVEKDSSGEHSAALTLYSR-----ALEYFIPALHYESDVR 324

  Fly   317 AKSPLQQQL------EQELKLVKLAEQQQK----------EREEQEAQEDENTVSVVANPAICAT 365
            .|..::.::      .:|||:  |.....|          |..::.||:.....|.:       .
Frog   325 RKEAIRSKVCQYISRAEELKV--LVSSNNKTLLMQGISGWELLKEMAQDKPRLFSAL-------E 380

  Fly   366 ITNVGVLCDSENNSGSCSSHEDSDDFVLVPKNLPE----------DQRQGLAQVQAQPASGGQRP 420
            :.:..|..|.|    .|:    ||...|..::|.|          .:|:.|...:.|...|....
Frog   381 VASAAVAKDEE----GCA----SDALDLYQQSLGELLLMLSAESPGRRRELLHAEIQTIMGRAEF 437

  Fly   421 QQQQNQSSPPRPSSL 435
            .::|.::|..:..||
Frog   438 LKEQMKTSQWKSESL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	111/263 (42%)
		STKc_ULK1_2-like	15..273	CDD:271022	111/260 (43%)
		DUF3543	638..844	CDD:288883
ulk3	XP_012821384.1	STKc_ULK3	17..268	CDD:271023	111/262 (42%)
		MIT	278..352	CDD:381929	16/80 (20%)
		MIT	378..440	CDD:367874	13/76 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920