DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42709 and RTN4R

DIOPT Version :9

Sequence 1:NP_001163434.1 Gene:CG42709 / 39453 FlyBaseID:FBgn0261674 Length:458 Species:Drosophila melanogaster
Sequence 2:NP_075380.1 Gene:RTN4R / 65078 HGNCID:18601 Length:473 Species:Homo sapiens


Alignment Length:208 Identity:49/208 - (23%)
Similarity:84/208 - (40%) Gaps:27/208 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 CPRNCLCLEDFKF-VQCANAHLTHVPLDMP------------------------KTAAIIDLSHN 132
            ||..|:|..:.|. ..|....|..||:.:|                        :...|:.|..|
Human    27 CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSN 91

  Fly   133 VIAELRPEDFANLSRAVEINLNHNL-ISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAKEL 196
            |:|.:....|..|:...:::|:.|. :.|:|...|.|..||..|.|....|.::.|..|.....|
Human    92 VLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAAL 156

  Fly   197 TLLDLSNNTITQRLDGSFLNQPDLVEFSCVNCSWTELPEQTFQNMSGLEVLRLNKNDFKQQINTK 261
            ..|.|.:|.:....|.:|.:..:|..........:.:||:.|:.:..|:.|.|::|.. ..::..
Human   157 QYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRV-AHVHPH 220

  Fly   262 AFSPLTKIIKLKL 274
            ||..|.:::.|.|
Human   221 AFRDLGRLMTLYL 233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42709NP_001163434.1 LRR_8 126..182 CDD:290566 17/56 (30%)
leucine-rich repeat 128..147 CDD:275380 6/18 (33%)
leucine-rich repeat 148..171 CDD:275380 6/23 (26%)
LRR_RI <150..225 CDD:238064 20/75 (27%)
LRR_8 171..254 CDD:290566 21/82 (26%)
leucine-rich repeat 172..195 CDD:275380 6/22 (27%)
leucine-rich repeat 196..219 CDD:275380 6/22 (27%)
leucine-rich repeat 220..243 CDD:275380 4/22 (18%)
leucine-rich repeat 244..268 CDD:275380 7/23 (30%)
RTN4RNP_075380.1 LRR 1. /evidence=ECO:0000255 55..79 1/23 (4%)
leucine-rich repeat 60..82 CDD:275380 0/21 (0%)
LRR 2. /evidence=ECO:0000255 81..103 6/21 (29%)
LRR_8 82..142 CDD:338972 17/59 (29%)
leucine-rich repeat 83..106 CDD:275380 7/22 (32%)
LRR 3. /evidence=ECO:0000255 104..128 6/23 (26%)
leucine-rich repeat 107..131 CDD:275380 6/23 (26%)
LRR 4. /evidence=ECO:0000255 129..152 7/22 (32%)
leucine-rich repeat 132..155 CDD:275380 6/22 (27%)
LRR 5. /evidence=ECO:0000255 153..176 6/22 (27%)
LRR_8 156..214 CDD:338972 14/57 (25%)
leucine-rich repeat 156..179 CDD:275380 6/22 (27%)
LRR 6. /evidence=ECO:0000255 178..200 4/21 (19%)
leucine-rich repeat 180..203 CDD:275380 4/22 (18%)
LRR 7. /evidence=ECO:0000255 202..224 6/22 (27%)
LRR_8 203..261 CDD:338972 9/32 (28%)
leucine-rich repeat 204..227 CDD:275380 7/23 (30%)
LRR 8. /evidence=ECO:0000255 225..248 3/9 (33%)
leucine-rich repeat 228..251 CDD:275380 2/6 (33%)
LRR 9. /evidence=ECO:0000255 250..273
TPKR_C2 260..>296 CDD:387596
DUF390 332..>417 CDD:282014
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 346..447
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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