Protein Alignment CG42709 and islr2

DIOPT Version :10

• Sequence 1: NP_648600.1
• Gene: CG42709 / 39453
• FlyBaseID: FBgn0261674
• Length: 458
• Species: Drosophila melanogaster
• Sequence 2: NP_001013541.1
• Gene: islr2 / 541396
• ZFINID: ZDB-GENE-050320-95
• Length: 712
• Species: Danio rerio
• Alignment Length: 396
• Identity: 93/396 - (23%)
• Similarity: 154/396 - (38%)
• Gaps: 103/396 - (26%)

  Fly    93 CPRNCLCLEDF--KFVQCANAHLTHVPLDMPKTAAIIDLSHNVIAELRPEDFANLSRAVEINLNH 155
            ||:.|.|.:.:  :||.||...|..||:.:|..|:.:.||.|.|..|:.:.|.|:::...:.|.|
Zfish    22 CPKQCACSDKYNHQFVDCAYKDLVEVPVGLPSNASTLSLSANKIKVLKSKTFVNVTQVTSLWLAH 86

  Fly   156 NLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAKELTLLDLSNNTITQRLDGSFLNQPDL 220
            |.|.::::|......:||.|.::||::.....:..|....|.||.::||.:......:|.|..||
Zfish    87 NEIITVERDTLAPLIQLKNLDISNNKIVHFPWEDLANLGALQLLKMNNNEMVSIPKNAFSNLKDL 151

  Fly   221 VEFSCVNCSWTELPEQTFQNMSGLEVLRLNKNDF--------------------KQQINTKAFSP 265
            ......|..:|.:.:.||.:::.:..|::..|.|                    .:|.|....:|
Zfish   152 RSIRINNNKFTTIVQGTFDSLAAMSHLQIFHNPFICSCNLEWLRDWILKSSISIPEQNNIACDAP 216

  Fly   266 -------LTKIIKL--KLPELE---QQNIEELCSLLTSIDTISFLNYDISCYEFVLGTP------ 312
                   :|.:.||  |.|.:.   |.|||:         |..:..|.:..|....|||
Zfish   217 SHLKGSQVTSMPKLNCKAPSVSITYQPNIEK---------TELYEGYMVMLYCETKGTPKPEVTW 272

  Fly   313 --FNG---------SLIYPTEPPLKGITNPPIVASITSTAKPV--TATPAPPR-----------S 353
              |.|         :::..::.|:.|   ||     |:|...|  ..|...||           |
Zfish   273 EIFAGNQLITFPLPAIVEKSDIPING---PP-----TNTRFLVFQNGTLIVPRMSKKEEGNYTCS 329

  Fly   354 ANRNRGKMDNSTELVKAGILSSETST----------------------SGVSVEPPAESQTNQVQ 396
            |..:.||.::|..||.||.....|::                      |.:|:.|..|.:|..:.
Zfish   330 AVNDIGKAESSVRLVVAGTKKHATNSMLDTKSPGLLPEDKLGSKGSKNSVISMRPKFEEKTKSLP 394

  Fly   397 ISQEAI 402
            .....|
Zfish   395 TGTSVI 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42709	NP_648600.1	LRR	<127..>300	CDD:443914	47/204 (23%)
		leucine-rich repeat	128..147	CDD:275380	7/18 (39%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	5/22 (23%)
		leucine-rich repeat	244..268	CDD:275380	6/50 (12%)
islr2	NP_001013541.1	LRR	<35..>182	CDD:443914	41/146 (28%)
		leucine-rich repeat	35..53	CDD:275380	7/17 (41%)
		leucine-rich repeat	57..78	CDD:275380	7/20 (35%)
		leucine-rich repeat	79..102	CDD:275380	5/22 (23%)
		leucine-rich repeat	103..126	CDD:275380	6/22 (27%)
		leucine-rich repeat	127..150	CDD:275380	7/22 (32%)
		leucine-rich repeat	151..174	CDD:275380	5/22 (23%)
		LRRCT	183..>221	CDD:214507	5/37 (14%)
		Ig	240..345	CDD:472250	28/121 (23%)
		Ig strand B	256..260	CDD:409405	0/3 (0%)
		Ig strand C	269..273	CDD:409405	0/3 (0%)
		Ig strand E	312..315	CDD:409405	1/2 (50%)
		Ig strand F	325..330	CDD:409405	0/4 (0%)
		Ig strand G	338..341	CDD:409405	0/2 (0%)