DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42709 and Tollo

DIOPT Version :9

Sequence 1:	NP_001163434.1	Gene:	CG42709 / 39453	FlyBaseID:	FBgn0261674	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	311	Identity:	72/311 - (23%)
Similarity:	128/311 - (41%)	Gaps:	33/311 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GLLLIFLLSVSISH-TNAAPAGSEEANPLEDFNYGDDDYSETATG--EESPE-----TAENRLMP 64
            |||.:.::.:|.:. |:..|....|...|::....::..:..|.|  .|..|     .|.|.|..
  Fly   256 GLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNS 320

  Fly    65 QSSSTSTTTTFRPIF-------NIPRRSNHVLEPSCPRNCLCLEDFKFVQCANAHLTHVP----L 118
            |..:.:|....:.:.       .|.|...|:..|......|.|||        .::..:|    .
  Fly   321 QWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLED--------NYIDQLPGGIFA 377

  Fly   119 DMPKTAAIIDLSHNVIAELRPEDFANLSRAVEINLNHNLISSIDKDVFQGSERLKRLRLANNRLT 183
            |:.....:| ||.|.|:.:.......|...:.::|:.|.||.:|:.......:|:.|.|.:|:|.
  Fly   378 DLTNLHTLI-LSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQ 441

  Fly   184 KIDPDTFAAAKELTLLDLSNNTITQRLDGSFLNQPDLVEFSCVNCSWTELPEQTFQNMSGLEVLR 248
            .: |:..|..:.|..||:..|.|:|..:.|......|........|.|.:....|..||.|::|.
  Fly   442 AV-PEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILN 505

  Fly   249 LNKNDFKQQINTKAFSPLTKIIKLKLPELEQQNIEELCSLLTSIDTISFLN 299
            |::|..|   :.:|.| |.:..:|:...|:...::.:..|.|.:..:.:||
  Fly   506 LSQNKLK---SIEAGS-LQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLN 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42709	NP_001163434.1	LRR_8	126..182	CDD:290566	15/55 (27%)
		leucine-rich repeat	128..147	CDD:275380	5/18 (28%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		LRR_RI	<150..225	CDD:238064	20/74 (27%)
		LRR_8	171..254	CDD:290566	24/82 (29%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	5/22 (23%)
		leucine-rich repeat	244..268	CDD:275380	8/23 (35%)
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	6/24 (25%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	72/311 (23%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380	2/2 (100%)
		leucine-rich repeat	260..283	CDD:275380	4/22 (18%)
		LRR_RI	276..558	CDD:238064	66/291 (23%)
		leucine-rich repeat	284..307	CDD:275380	4/22 (18%)
		leucine-rich repeat	308..333	CDD:275380	5/24 (21%)
		leucine-rich repeat	334..357	CDD:275380	4/22 (18%)
		leucine-rich repeat	358..381	CDD:275380	6/30 (20%)
		leucine-rich repeat	382..405	CDD:275380	6/23 (26%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	7/22 (32%)
		leucine-rich repeat	453..500	CDD:275380	12/46 (26%)
		leucine-rich repeat	501..521	CDD:275380	8/23 (35%)
		leucine-rich repeat	525..547	CDD:275380	4/21 (19%)
		leucine-rich repeat	548..573	CDD:275380	2/5 (40%)
		leucine-rich repeat	604..640	CDD:275380
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453658
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930