DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42709 and Lrit2

DIOPT Version :9

Sequence 1:	NP_001163434.1	Gene:	CG42709 / 39453	FlyBaseID:	FBgn0261674	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_775594.1	Gene:	Lrit2 / 239038	MGIID:	2444885	Length:	549	Species:	Mus musculus

Alignment Length:	333	Identity:	74/333 - (22%)
Similarity:	128/333 - (38%)	Gaps:	82/333 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 HVLEPSCPRNCLCLEDF--KFVQCANAHLTHVPLDMPKTAAIIDLSHNVIAELRPEDFANLSRAV 149
            |.::|.|...|.|.|:.  :.:||.:..|..:|.:.|:....:.:.::.:.||....|.|:|...
Mouse    18 HAVQPFCLPECTCSEESFGRSLQCMSMSLGKIPDNFPEELKQVRIENSPLFELSQGFFTNMSSLE 82

  Fly   150 EINLNHNLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAKELTLLDLSNNTITQRLDGSF 214
            .:.||.|.::.|.....:....|:.|||..|:|..:....|.|...|.:|||.:|    |:|
Mouse    83 YLWLNFNNVTVIHLGALEDLPELRELRLEGNKLRSVPWTAFRATPLLRVLDLKHN----RID--- 140

  Fly   215 LNQPDLVEFSCVNCSWTELPEQTFQNMSGLEVLRLNKNDFKQQINTKAFSPLTKIIKLKLPELEQ 279
                             .:||...|.::.|..|.::.|         ..:.::|.:.|..|..::
Mouse   141 -----------------SVPELALQFLTNLIYLDISSN---------RLTVVSKGVFLNWPAYQK 179

  Fly   280 Q-----NIEELCSLLTSIDTISFLNYDISC-----YEFV--LGTPF---------------NGSL 317
            :     ..|.|.:::.|:....:|   ..|     .:||  :|.||               .|.|
Mouse   180 RQQLGCGAEFLSNMVLSLHNNPWL---CDCRLRGLAQFVKSVGPPFILVNSYLVCQGPVSKAGQL 241

  Fly   318 IYPTE--PPLKGITNPPIVASITSTAKPVT------ATPAP------PRSANRNRGKMDNSTELV 368
            ::.||  ..:|...:.|.|.......|.||      |:|:|      |.|..|   :.|.....:
Mouse   242 LHETELGVCMKPTISTPSVNVTIQVGKNVTLQCFAQASPSPTIAWKYPLSTWR---EFDVLASPI 303

  Fly   369 KAGILSSE 376
            ..||:.|:
Mouse   304 AEGIILSQ 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42709	NP_001163434.1	LRR_8	126..182	CDD:290566	14/55 (25%)
		leucine-rich repeat	128..147	CDD:275380	4/18 (22%)
		leucine-rich repeat	148..171	CDD:275380	4/22 (18%)
		LRR_RI	<150..225	CDD:238064	19/74 (26%)
		LRR_8	171..254	CDD:290566	21/82 (26%)
		leucine-rich repeat	172..195	CDD:275380	8/22 (36%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	3/22 (14%)
		leucine-rich repeat	244..268	CDD:275380	3/23 (13%)
Lrit2	NP_775594.1	LRR_8	56..115	CDD:290566	14/58 (24%)
		leucine-rich repeat	57..80	CDD:275378	4/22 (18%)
		LRR_4	80..119	CDD:289563	10/38 (26%)
		leucine-rich repeat	81..104	CDD:275378	4/22 (18%)
		LRR_8	103..163	CDD:290566	21/92 (23%)
		leucine-rich repeat	105..128	CDD:275378	8/22 (36%)
		LRR_4	129..164	CDD:289563	13/67 (19%)
		leucine-rich repeat	129..152	CDD:275378	10/46 (22%)
		leucine-rich repeat	153..164	CDD:275378	3/19 (16%)
		leucine-rich repeat	193..204	CDD:275378	2/13 (15%)
		TPKR_C2	200..243	CDD:301599	9/45 (20%)
		I-set	253..344	CDD:254352	15/62 (24%)
		Ig	266..345	CDD:299845	13/49 (27%)
		fn3	367..441	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000