DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42709 and LRRC38

DIOPT Version :9

Sequence 1:	NP_001163434.1	Gene:	CG42709 / 39453	FlyBaseID:	FBgn0261674	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001010847.1	Gene:	LRRC38 / 126755	HGNCID:	27005	Length:	294	Species:	Homo sapiens

Alignment Length:	189	Identity:	54/189 - (28%)
Similarity:	83/189 - (43%)	Gaps:	28/189 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 VLEP--SCPRNCLCLEDFKFVQCANAHLTHVPLDMPKTAAIIDLSHNVIAELRPEDFANLSRAVE 150
            :|.|  :||..|.| .|...|.|.:..|..||...|.....:.::.|.|..: ||||.
Human    21 LLAPGHACPAGCAC-TDPHTVDCRDRGLPSVPDPFPLDVRKLLVAGNRIQRI-PEDFF------- 76

  Fly   151 INLNHNLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAAKELTLLDLSNNTITQRLDGSFL 215
                          :|.|.  |..|...||.|..::..||:.:.:|..||||.|.:||...|:|.
Human    77 --------------IFYGD--LVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFR 125

  Fly   216 NQPDLVEFSCVNCSWTELPEQTFQNMSGLEVLRLNKNDFKQQINTKAFSPLTKIIKLKL 274
            :...||:.|..|.:...:.|..|:.:..|:||.||.|:.: .::..|.:.|..:..|:|
Human   126 SAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR-SLSVAALAALPALRSLRL 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42709	NP_001163434.1	LRR_8	126..182	CDD:290566	12/55 (22%)
		leucine-rich repeat	128..147	CDD:275380	6/18 (33%)
		leucine-rich repeat	148..171	CDD:275380	2/22 (9%)
		LRR_RI	<150..225	CDD:238064	21/74 (28%)
		LRR_8	171..254	CDD:290566	29/82 (35%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	6/22 (27%)
		leucine-rich repeat	244..268	CDD:275380	8/23 (35%)
LRRC38	NP_001010847.1	LRRNT	27..58	CDD:214470	11/31 (35%)
		leucine-rich repeat	38..56	CDD:275380	5/17 (29%)
		LRR_RI	<45..>165	CDD:238064	41/143 (29%)
		LRR 1	57..78		6/42 (14%)
		LRR_8	58..116	CDD:290566	21/81 (26%)
		leucine-rich repeat	58..81	CDD:275378	7/44 (16%)
		LRR 2	81..102		7/22 (32%)
		leucine-rich repeat	82..105	CDD:275378	7/22 (32%)
		LRR 3	105..126		10/20 (50%)
		leucine-rich repeat	106..129	CDD:275378	10/22 (45%)
		LRR_8	109..164	CDD:290566	21/54 (39%)
		LRR 4	129..150		6/20 (30%)
		leucine-rich repeat	130..153	CDD:275378	6/22 (27%)
		LRR 5	153..174		7/21 (33%)
		leucine-rich repeat	154..165	CDD:275378	6/10 (60%)
		leucine-rich repeat	178..197	CDD:275380	2/6 (33%)
		TPKR_C2	186..237	CDD:301599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000