DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hip1 and HIP1R

DIOPT Version :9

Sequence 1:	NP_648597.2	Gene:	Hip1 / 39450	FlyBaseID:	FBgn0036309	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_003950.1	Gene:	HIP1R / 9026	HGNCID:	18415	Length:	1068	Species:	Homo sapiens

Alignment Length:	1157	Identity:	339/1157 - (29%)
Similarity:	546/1157 - (47%)	Gaps:	211/1157 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AEKEFYHLN--VSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKF 67
            ||:|.:...  :|:|||:|..|||:|.||||.||:..|..|.|.|||......||..|...:|||
Human    22 AEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKF 86

  Fly    68 SHLLHKVLREGHESAIRHSQSHKKMILEVGKMWGLLQDDIGCCIQAYSKLLATKLNFHDKNRMFP 132
            .|:||||||:||.:.:...|.::..|.|:|.:||.|.|..|..:..|:|||.||::||.|:..||
Human    87 CHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFP 151

  Fly   133 GTLNISFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPI 197
            ..|.::...|..|...|:|..|||.||:|||::..:.|..::|..:......|....|||||||:
Human   152 AGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPL 216

  Fly   198 VCLIQDSNALYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPE 262
            :.:|||.:.||..:|:|:||||..:|.|.:.|||||||..|..|::|:.....:.|||.||.||.
Human   217 IQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPR 281

  Fly   263 LPDSSPNFKSQNDFTSYVPPVVHVPQEPDPVVEDLVDTNNHELEAFSQAQQQLSMLE-------- 319
            ||:..|||...:....::.|||.:|:|   ..||....|..|:.....|.:.:.:.:
Human   282 LPEGPPNFLRASALAEHIKPVVVIPEE---APEDEEPENLIEISTGPPAGEPVVVADLFDQTFGP 343

  Fly   320 ---GIISEKEASIEELSFKLDAMQKNFDALQQSYRHDVQELQQNNTVLSNDLVLAREMCATFRMQ 381
               .:..:::..||.|..:::.::...:.::...:..:.:|:.....|..:|...|:......:.
Human   344 PNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVD 408

  Fly   382 NDDLEMQLNQNPILLQKAM-----------EEEEKHKLSSEKFNKLKTLYTKIRDEHIQLLREQS 435
            |:.|..:|.|    |:.|.           |.|.|...:..::||||..::::...|.:|||:.:
Human   409 NEQLRHELAQ----LRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNA 469

  Fly   436 DCNKSLNKEKQVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKEKIA-HLEAVKNE 499
            |..|.|...:|                                .|:::...||::| .:|.||.|
Human   470 DTAKQLTVTQQ--------------------------------SQEEVARVKEQLAFQVEQVKRE 502

  Fly   500 MKEKFDDVVKQKEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLSNAESQINAKTEDIEKML 564
            .:                            ||:||                     |::.:||:.
Human   503 SE----------------------------LKLEE---------------------KSDQLEKLK 518

  Fly   565 KAFEAEKALLLTQIEQQSVESKSHSEAQNAQLQEIMDNLE-QKDKEFNEVKLQLSSAESQISLKA 628
            :..||:...|     .::.|:.||:|...::|...:|.|. :||        .||.|..|.....
Human   519 RELEAKAGEL-----ARAQEALSHTEQSKSELSSRLDTLSAEKD--------ALSGAVRQREADL 570

  Fly   629 LEIQNNLKAFEAEKSVLLTKIEQLGIEHKNNSEAQNAQLQLTLNNLEQNESALQQ--TQEIVNQL 691
            |..|:.::..||          .|..|.:.:|:.| .:||..|...|..|..|:|  ..|....|
Human   571 LAAQSLVRETEA----------ALSREQQRSSQEQ-GELQGRLAERESQEQGLRQRLLDEQFAVL 624

  Fly   692 RQENASAGQRNEDLQSKL---------SLTEVKLTQATQQIDAVTS---SYQICSTDLSELRKLV 744
            |...|.|....:|..|||         |..:..:::|.:.:|||::   .:....|.|::...||
Human   625 RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALV 689

  Fly   745 IKTVKEICNSKLSGSEQQPLDAVPNIIREMETILNKFNNASAINYVASTEGLQNVMYLGYVFIKL 809
            ....:   .|.|:.                :||:    |..|.:::|.|:...          :|
Human   690 AALTR---FSHLAA----------------DTII----NGGATSHLAPTDPAD----------RL 721

  Fly   810 YDQCDVIYKTTTAIETGQEIFSKTNLLCTDICQLFQYLLNNETKEPERQKTITDIQTKLRDIEKL 874
            .|.|.         |.|.........|              :.::..|....:.::|.|:.|.:|
Human   722 IDTCR---------ECGARALELMGQL--------------QDQQALRHMQASLVRTPLQGILQL 763

  Fly   875 IEKIK-ASFE-QKIDLDKLLEIELREMDAAIDDAASKITDLLAKAREKDNQTNLEVNGKIVDACT 937
            .:::| .|.: ::.:|..:::.|:....|||:||..:|.|::.:||...:...||||.:|:::||
Human   764 GQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCT 828

  Fly   938 TLMECVKALIQKSRLLQHEIVASQKGNASANEFYRRNSQWSDGLISASKSVAKAANYLVEAANKA 1002
            .||:.::.|:..|..||.|||.|.:|.|:..|||.:||:|::|||||||:|...|..|||||:|.
Human   829 DLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKV 893

  Fly  1003 IESESGKNFELIVAAQEIAACTTQMVIASKVKAERNSQKLTDLTKASRSVTQATGTLVATVKDCN 1067
            : ..:||..||||.:.||||.|.|:|.||||||.::|..|:.|.:.||:|.:....:||:.|...
Human   894 V-LHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQ 957

  Fly  1068 SQLEQQSEIELSKLTPSQIKTMEMEIHVKVLEIEQALQMQRLKLSSFRKEHY 1119
            .|:|.:..::.|.|:..::|..|||..|:|||:|:.|:.:|::|...||:||
Human   958 EQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	9..281	CDD:284961	114/273 (42%)
		TMPIT	402..>504	CDD:285135	22/102 (22%)
		I_LWEQ	973..1120	CDD:279885	66/147 (45%)
HIP1R	NP_003950.1	ANTH	28..300	CDD:284961	114/271 (42%)
		RILP-like	<349..467	CDD:304877	23/121 (19%)
		PspA	383..604	CDD:224755	67/329 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..443		3/18 (17%)
		HIP1_clath_bdg	461..559	CDD:293123	35/191 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..549		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..608		9/36 (25%)
		ILWEQ	814..1012	CDD:214607	88/197 (45%)
		Important for actin binding	867..924		32/57 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147621
Domainoid	1	1.000	237	1.000	Domainoid score	I2323
eggNOG	1	0.900	-	-		E1_KOG0980
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1754
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55957
OrthoDB	1	1.010	-	-		D104219at2759
OrthoFinder	1	1.000	-	-		FOG0002012
OrthoInspector	1	1.000	-	-		otm42173
orthoMCL	1	0.900	-	-		OOG6_102577
Panther	1	1.100	-	-	O	PTHR10407
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1344
SonicParanoid	1	1.000	-	-		X1787
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800