DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hip1 and SLA2

DIOPT Version :9

Sequence 1:	NP_648597.2	Gene:	Hip1 / 39450	FlyBaseID:	FBgn0036309	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_014156.2	Gene:	SLA2 / 855478	SGDID:	S000005187	Length:	968	Species:	Saccharomyces cerevisiae

Alignment Length:	1175	Identity:	248/1175 - (21%)
Similarity:	472/1175 - (40%)	Gaps:	279/1175 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LNVSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKFSHLLHKVLR 76
            |..::.||.:..|...|.||.|:.|:.....:.:|..:..:...||.......:|...:|||:::
Yeast     8 LQKALKKACSVEETAPKRKHVRACIVYTWDHQSSKAVFTTLKTLPLANDEVQLFKMLIVLHKIIQ 72

  Fly    77 EGHESAIRHSQSHKKMILEVGKM--WGLLQDDIGCCIQAYSKLLATKLNFHDKNRMF-PGTLNI- 137
            |||.||:..:...:..|..:|::  .|.....:   |:.|.:.|..||:||..:|.| .||...
Yeast    73 EGHPSALAEAIRDRDWIRSLGRVHSGGSSYSKL---IREYVRYLVLKLDFHAHHRGFNNGTFEYE 134

  Fly   138 SFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPIVCLIQ 202
            .:..|....|.|..|  :..:::....:.:......||:|::..|.::     :|:::.::.||.
Yeast   135 EYVSLVSVSDPDEGY--ETILDLMSLQDSLDEFSQIIFASIQSERRNT-----ECKISALIPLIA 192

  Fly   203 DSNALYDLSVRLMFKLH----DGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPEL 263
            :|..:|.....::..:|    |......:...::|:.....:|..||.:...::|...|:|||:|
Yeast   193 ESYGIYKFITSMLRAMHRQLNDAEGDAALQPLKERYELQHARLFEFYADCSSVKYLTTLVTIPKL 257

  Fly   264 PDSSPNFKSQNDF------------------------TSYVPPVVHVPQ-EPDPVVEDLVDTNNH 303
            |..:|:....||.                        .:..||||..|. .|.||.:....|...
Yeast   258 PVDAPDVFLINDVDESKEIKFKKREPSVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTG 322

  Fly   304 ELEAFSQAQQQLSMLEGIISEKEASIEELSFKLDAMQKNFDALQQSYRHDVQELQQNNTVLSNDL 368
            .|:..........|:........|...:.:.:   ||.:|.|.||
Yeast   323 YLQTMPTGATTGMMIPTATGAANAIFPQATAQ---MQPDFWANQQ-------------------- 364

  Fly   369 VLAREMCATFRMQNDDLEMQLNQNPILLQKAMEEEEKHKLSSEKFNKLKTLYTKIRDEHIQLLRE 433
                   |.|..:.:.||          |:.:::.::.:...|.|.:             ||.:.
Yeast   365 -------AQFANEQNRLE----------QERVQQLQQQQAQQELFQQ-------------QLQKA 399

  Fly   434 QSD-CNKSLNKEKQVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKEKIAHLEAVK 497
            |.| .|..|.::.|..:.|:    .|||:.          ||...:||    ::.:::..||:
Yeast   400 QQDMMNMQLQQQNQHQNDLI----ALTNQY----------EKDQALLQ----QYDQRVQQLES-- 444

  Fly   498 NEMKEKFDDVVKQKEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLSNAESQINAKTEDIEK 562
                          ||..:|  ||:.                    ::|:|.:.|:.|..:.::.
Yeast   445 --------------EITTMD--STAS--------------------KQLANKDEQLTALQDQLDV 473

  Fly   563 MLKAFEAEKALLLTQIEQQSVESKSHSEAQNAQLQEIMDNLEQKDKEFNEVKLQLSSAESQISLK 627
            ..:.:|: .|.|.:|:.|:.:                  ||..:   |.:::|:::||:..|..|
Yeast   474 WERKYES-LAKLYSQLRQEHL------------------NLLPR---FKKLQLKVNSAQESIQKK 516

  Fly   628 ALEIQNNLKAFEAEKSVLLTKIEQLGIEHK---NNSEAQNAQLQLTLNNLEQN----------ES 679
            . ::::.||..:.:.:.|:...::..:|.:   ||:||.:|........:.|:          ||
Yeast   517 E-QLEHKLKQKDLQMAELVKDRDRARLELERSINNAEADSAAATAAAETMTQDKMNPILDAILES 580

  Fly   680 ALQQTQEIVNQLRQENASAGQRNEDLQSKLSLTEVKLTQATQQIDAVTSSYQICSTDLSELRKLV 744
            .:...||.|              .:|.|.||.:. .||..|..:..:.|:.:..:...:....|:
Yeast   581 GINTIQESV--------------YNLDSPLSWSG-PLTPPTFLLSLLESTSENATEFATSFNNLI 630

  Fly   745 IKTVKEICNSKLSGSEQQPLDAVPNIIREMETILNKFNNASAINYVASTEGLQNVMYLGYVFIKL 809
            :       :....|.:.:.:..|.:....|.|::.. :.|.|:
Yeast   631 V-------DGLAHGDQTEVIHCVSDFSTSMATLVTN-SKAYAV---------------------- 665

  Fly   810 YDQCDVIYKTTTAIETGQEIFSKTNLLCTDICQLFQYLLN---NETKEPERQKTI----TDIQTK 867
                     ||...|...:|.:.......:....|:.|::   |:..:.|:...:    .|:|.|
Yeast   666 ---------TTLPQEQSDQILTLVKRCAREAQYFFEDLMSENLNQVGDEEKTDIVINANVDMQEK 721

  Fly   868 LRDIEKLIEKIKASFEQKIDLDKLLEIELREMDAAIDDAASKI--TDLLAKAREKDNQTNLEVNG 930
            |:::...||             .||.|:..:.:...:..:..:  .|.:.|:.|   ...::|..
Yeast   722 LQELSLAIE-------------PLLNIQSVKSNKETNPHSELVATADKIVKSSE---HLRVDVPK 770

  Fly   931 KIVDACTTLMECVKALIQKSRLLQHEIVASQKGNASANEFYRRNSQWSDGLISASKSVAKAANYL 995
            .::.....:::.|.||::.:...|:||..:.  :...|:||.:||:|::|||||:|:||.|.|.|
Yeast   771 PLLSLALMIIDAVVALVKAAIQCQNEIATTT--SIPLNQFYLKNSRWTEGLISAAKAVAGATNVL 833

  Fly   996 VEAANKAIESESGKNF---ELIVAAQEIAACTTQMVIASKVKAERNSQKLTDLTKASRSVTQATG 1057
            :..|:|.|.||..:|.   :.|||::|:||.|.|:|.||:||...:|:....|...|:.||.|..
Yeast   834 ITTASKLITSEDNENTSPEQFIVASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCSKDVTDACR 898

  Fly  1058 TL----VATVKDCNSQLEQQSEIELSKLTPSQIKTMEMEIHVKVLEIEQALQMQRLKLSSFRKEH 1118
            :|    :..::|.:|..:||..::.:  :...:||.|||..|::|::||:|...|.:|...|:..
Yeast   899 SLGNHVMGMIEDDHSTSQQQQPLDFT--SEHTLKTAEMEQQVEILKLEQSLSNARKRLGEIRRHA 961

  Fly  1119 YKNAD 1123
            |.|.|
Yeast   962 YYNQD 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	9..281	CDD:284961	64/300 (21%)
		TMPIT	402..>504	CDD:285135	19/102 (19%)
		I_LWEQ	973..1120	CDD:279885	57/153 (37%)
SLA2	NP_014156.2	ANTH	7..269	CDD:400137	62/270 (23%)
		Smc	<420..>546	CDD:224117	35/200 (18%)
		ILWEQ	763..965	CDD:214607	68/205 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343937
Domainoid	1	1.000	99	1.000	Domainoid score	I1583
eggNOG	1	0.900	-	-		E1_KOG0980
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	139	1.000	Inparanoid score	I1191
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55957
OrthoFinder	1	1.000	-	-		FOG0002012
OrthoInspector	1	1.000	-	-		oto100282
orthoMCL	1	0.900	-	-		OOG6_102577
Panther	1	1.100	-	-	LDO	PTHR10407
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1344
SonicParanoid	1	1.000	-	-		X1787
TreeFam	1	0.960	-	-
	14	13.790