Protein Alignment Hip1 and Hip1r

DIOPT Version :9

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_008767488.1
• Gene: Hip1r / 81917
• RGDID: 621615
• Length: 1076
• Species: Rattus norvegicus
• Alignment Length: 1188
• Identity: 355/1188 - (29%)
• Similarity: 547/1188 - (46%)
• Gaps: 265/1188 - (22%)

  Fly     5 AEKEFYHLN--VSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKF 67
            ||:|.:...  :|:|||:|..|||:|.||||.||:..|..|.|.|||......||..|...:|||
  Rat    22 AEREQFDKTQAISISKAINSQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKF 86

  Fly    68 SHLLHKVLREGHESAIRHSQSHKKMILEVGKMWGLLQDDIGCCIQAYSKLLATKLNFHDKNRMFP 132
            .|:||||||:||.:.:...|.::..|.|:|.:||.|:|..|..:..|:|||.||::||.|:..||
  Rat    87 CHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLRDQYGHLVNIYTKLLLTKISFHLKHPQFP 151

  Fly   133 GTLNISFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPI 197
            ..|.::...|..|...|:|..|||.||:|||::..:.|..::|..:......|....|||||||:
  Rat   152 AGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPL 216

  Fly   198 VCLIQDSNALYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPE 262
            :.:|||.:.||..:|:||||||..:|.|.:.|||||||..|..|::|:.....:.|||.||.||.
  Rat   217 IQVIQDCSHLYHYTVKLMFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPR 281

  Fly   263 LPDSSPNFKSQNDFTSYVPPVVHVPQ---------------------EPDPVVEDL--------- 297
            ||:..|||...:....::.|||.:|:                     ||..||.||
  Rat   282 LPEGPPNFLRASALAEHIKPVVVIPEEAPEEEEPENLIEISSGPPAGEPVQVVADLFDQTFGPPN 346

  Fly   298 -----------------VDTNNHELEAFS-QAQQQLSMLEGIISEKEASIEELSFKLDAMQKNFD 344
                             |:|...|||... :||:.:|.|:|.::..||.:||
  Rat   347 GSMKDDRDLQIENLKREVETLRAELEKIKMEAQRYISQLKGQVNSLEAELEE------------- 398

  Fly   345 ALQQSYRHDVQELQQNNTVLSNDLVLAREMCATFRMQNDDLEMQLNQNPILLQKAMEEEEKHKLS 409
                      |..|:...::.|: .|..|:.....:|   ||...||       .:.||.:.|.|
  Rat   399 ----------QRKQKQKALVDNE-QLRHELAQLKALQ---LEGARNQ-------GLREEAERKAS 442

  Fly   410 S--EKFNKLKTLYTKIRDEHIQLLREQSDCNKSLNKEKQVNSQLLLETKELTNEISKIKVNVEEK 472
            :  .:::|||..:.::.:.|.:|||:.:|..|.|...:|
  Rat   443 ATEARYSKLKEKHNELINTHAELLRKNADTAKQLTVTQQ-------------------------- 481

  Fly   473 EKTNLILQKQIEEHKEKIA-HLEAVKNEMKEKFDDVVKQKEIQELDIISTSENLRLNCLKVEELN 536
                  .|:::...||::| .:|.||.|.:                            :|:||
  Rat   482 ------SQEEVARVKEQLAFQMEQVKRESE----------------------------MKMEE-- 510

  Fly   537 GNLNDTLEKLSNAESQINAKTEDIEKMLKAFEAEKALLLTQIEQQSVESKSHSEAQNAQLQEIMD 601
              .:|.||||         |.|.:.|..:...|::|  |::.||...|..|..:..||:.:.:..
  Rat   511 --QSDQLEKL---------KRELVAKAGELAHAQEA--LSRTEQSGSELSSRLDTLNAEKEALSG 562

  Fly   602 NLEQKDKEFNEVKLQLSSAESQISLKALEIQNNLKAFEAEKSVLLTKIEQLGIEHKNNSEAQNAQ 666
            .:.|::.|       |.:|:|.:               .||...|::.:|       .|..:..:
  Rat   563 AIRQREAE-------LLAAQSLV---------------REKEEALSQEQQ-------RSAQEKGE 598

  Fly   667 LQLTLNNLEQNESALQQ--TQEIVNQLRQENASAGQRNEDLQSKLSLTEVKLTQATQQIDAVTSS 729
            ||..|...|..|..|||  ..|....||...|.|....:|..|||.  :....:.|...|.:.|.
  Rat   599 LQGRLAEKESQEQGLQQKLLDEQFAVLRGAAAEAEAILQDAVSKLD--DPLHLRCTSSPDYLVSR 661

  Fly   730 YQICSTDLSELRKLVIKTVKEICNSKLSGSEQ-----QPLDAVPNIIREMETILNKFN------- 782
            .|.....:|.|.|               |..|     :.|..||.....:...|.:|:
  Rat   662 AQAALDSVSGLEK---------------GHTQYLASSEALAFVPADASALVAALTRFSHLAADTI 711

  Fly   783 -NASAINYVASTEGLQNVMYLGYVFIKLYDQCDVIYKTTTAIETGQ---EIFSKTNLLCTDICQL 843
             |..|.:::|.|:...          :|.|.|.         |.|.   |:..:
  Rat   712 VNGGATSHLAPTDPAD----------RLIDTCR---------ECGARALELMGQ----------- 746

  Fly   844 FQYLLNNETKEPERQKTITDIQTKLRDIEKLIEKIK-ASFE-QKIDLDKLLEIELREMDAAIDDA 906
                |.::||.|..|.::  ::..|:.|.:|.:.:| .|.: ::.:|..:::.|:....|||:||
  Rat   747 ----LQDQTKLPRAQPSL--MRAPLQGILQLGQDLKPKSLDVRQEELGAMVDKEMAATSAAIEDA 805

  Fly   907 ASKITDLLAKAREKDNQTNLEVNGKIVDACTTLMECVKALIQKSRLLQHEIVASQKGNASANEFY 971
            ..:|.|::.:||.:.:...||||.:|:::||.||:.::.|:..|..||.|||.|.:|.|:..|||
  Rat   806 VRRIEDMMNQARHESSGVKLEVNERILNSCTDLMKAIRLLVMTSTSLQKEIVESGRGAATQQEFY 870

  Fly   972 RRNSQWSDGLISASKSVAKAANYLVEAANKAIESESGKNFELIVAAQEIAACTTQMVIASKVKAE 1036
            .:||:|::|||||||:|...|..|||:|:|.: ...||..||||.:.||||.|.|:|.||||||.
  Rat   871 AKNSRWTEGLISASKAVGWGATQLVESADKVV-LHMGKYEELIVCSHEIAASTAQLVAASKVKAN 934

  Fly  1037 RNSQKLTDLTKASRSVTQATGTLVATVKDCNSQLEQQSEIELSKLTPSQIKTMEMEIHVKVLEIE 1101
            :||..|:.|.:.||:|.:....:||:.|....|:|.:..::.|.|:..::|..|||..|:|||:|
  Rat   935 KNSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELE 999

  Fly  1102 QALQMQRLKLSSFRKEHY 1119
            :.|:.:|::|...||:||
  Rat  1000 KTLEAERVRLGELRKQHY 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	9..281	CDD:284961	115/273 (42%)
		TMPIT	402..>504	CDD:285135	23/104 (22%)
		I_LWEQ	973..1120	CDD:279885	66/147 (45%)
Hip1r	XP_008767488.1	ANTH	28..300	CDD:284961	115/271 (42%)
		RILP-like	<350..468	CDD:304877	34/151 (23%)
		Taxilin	358..614	CDD:286771	82/393 (21%)
		HIP1_clath_bdg	462..560	CDD:293123	36/172 (21%)
		ILWEQ	822..1020	CDD:214607	88/197 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341440
Domainoid	1	1.000	239	1.000	Domainoid score	I2202
eggNOG	1	0.900	-	-		E1_KOG0980
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2688
OMA	1	1.010	-	-		QHG55957
OrthoDB	1	1.010	-	-		D104219at2759
OrthoFinder	1	1.000	-	-		FOG0002012
OrthoInspector	1	1.000	-	-		otm46323
orthoMCL	1	0.900	-	-		OOG6_102577
Panther	1	1.100	-	-	O	PTHR10407
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1787
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.810