Protein Alignment Hip1 and hip1

DIOPT Version :9

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_005157489.1
• Gene: hip1 / 793823
• ZFINID: ZDB-GENE-010328-15
• Length: 1048
• Species: Danio rerio
• Alignment Length: 1168
• Identity: 369/1168 - (31%)
• Similarity: 567/1168 - (48%)
• Gaps: 216/1168 - (18%)

  Fly     6 EKEFYHLN--VSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKFS 68
            |||.:..|  ||::||:|..|..:|.||||:.|:..|..|.|.|||:.::|.||..:....|||.
Zfish    32 EKENFERNQAVSINKAINTQEVAVKEKHARTCILGTHHEKGAHTFWLAVNRLPLSSNAVLCWKFC 96

  Fly    69 HLLHKVLREGHESAIRHSQSHKKMILEVGKMWGLLQDDIGCCIQAYSKLLATKLNFHDKNRMFPG 133
            |:.||:||:||.:.|:.|..||..:.::.:|||.|.:..|.....|.|||.||:.||.||..|||
Zfish    97 HVFHKLLRDGHPNVIKDSMRHKADLNDMSRMWGHLSEGYGKLCSIYLKLLITKMEFHIKNPRFPG 161

  Fly   134 TLNISFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPIV 198
            .|.:|..:|..|.:.|:|..|||.||:|||||..:.|.|.:|||::..|..|:|..|||||||::
Zfish   162 NLQMSNRQLDEAGENDVNNFFQLTVEMFDYLECELNLFLGVFSSLDMSRSVSVTAAGQCRLAPLI 226

  Fly   199 CLIQDSNALYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPEL 263
            .:|.||:.|||.:|:|:||||..:|.|.:.||||||...|.||||.:.....|||||.||.||:|
Zfish   227 QVILDSSHLYDYTVKLLFKLHSCLPADTLQGHRDRFQEQFKKLKSLFYRSSNLQYFKRLIQIPQL 291

  Fly   264 PDSSPNFKSQNDFTSYVPPVVHVP-----QEPDPVV--EDLVDTNNHELEAFSQAQ--------- 312
            |::.|||...:..:.::.|||.:|     .|.:.||  ||||||:...|.....::
Zfish   292 PENPPNFLRASALSEHISPVVVIPAEASSPESEHVVETEDLVDTDIPPLTGTGDSKFDDLFGTSA 356

  Fly   313 --------QQLSMLEGIISEKEASIEELSFKLDAMQKNFDA-------LQQSYRHDVQELQ---Q 359
                    .|..|.:   .:|:..||:|:.:|.|:::..::       |.|:.|..|.||:   .
Zfish   357 ATDPFNFNSQNGMRK---DDKDRLIEQLTAELQALKEELESFRLESGRLCQALRGRVNELEAELA 418

  Fly   360 NNTVLSNDLVLAREMCATFRMQNDDLEMQLNQNPILLQKAMEE-EEKHKLSSEKFNKLKTLYTKI 423
            ..|.|....:...|.   .|.:.|||. ::.::....|:::.| |.|.:.:.:::.|||..||::
Zfish   419 EQTHLKQQALGESEF---LRAELDDLR-RVKEDTEKEQRSLSEIERKAQANEQRYTKLKEKYTEL 479

  Fly   424 RDEHIQLLREQSDCNKSLNKEKQVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKE 488
            ...|..|||:.:                     |:|.:::..:...:|
Zfish   480 VQSHADLLRKNA---------------------EVTRQMTVARAAQDE----------------- 506

  Fly   489 KIAHLEAVKNEMKEKF---DDVVKQKEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLSNAE 550
                :|.||.||:::.   .|...|:|..:|:        :|..|:.|.::....  ||.|.:..
Zfish   507 ----VENVKKEMQDRLKVAQDSASQQEKAQLE--------QLQALQAELMSSRTE--LETLKSTV 557

  Fly   551 SQINAKTEDIEKMLKAFEAEKALLLTQIEQQSVESKSHSEAQNAQLQEIMDNLEQKDKEFNEVKL 615
            :......|.:...|.|..||||.|:..:.::.||    .....|:|:.:..:|..
Zfish   558 TSSQQSNEQLGTQLSALVAEKAGLVETVSRKEVE----LSGLGAELERLQSSLTN---------- 608

  Fly   616 QLSSAESQISLKALEIQNNLKAFEAEKSVLLTKIEQLGIEHKNNSEAQNAQLQLTLNNLEQNESA 680
                          |.::.:||.||                          ||..||..|..|.|
Zfish   609 --------------ERESGVKAAEA--------------------------LQNQLNEKESREQA 633

  Fly   681 LQQTQEIVN----QLRQENASAGQRNEDLQSKLSLTEVKLTQATQQIDAVTSSYQICSTDLSELR 741
            |:  .|:|:    .||.....||:..:|  |...|.:......|...|.:.|..|:....:..||
Zfish   634 LE--SELVSLRWASLRAALEEAGKIVQD--SLNQLEDPAHISCTSSADYLVSRCQVALDCVERLR 694

  Fly   742 KLVIKTVKEICNSKLSG---SEQQPLDAVPNIIREMETILNKFNNASAINYVASTEGLQNVMYLG 803
            ......|.:  |:.:||   :..|....|.::|.:          .||.:::...|
Zfish   695 SSRDGFVSD--NTDVSGLVRAVTQFAHLVGDVIVQ----------GSATSHMVPVE--------- 738

  Fly   804 YVFIKLYDQCDVIYKTTTAIETGQEIFSKTNLLCTDICQLFQYLLNNETKEPERQ--KTITDIQT 866
                    |.|.:..:..|  .|.|..       |.:|||         ||.|..  ...:.::|
Zfish   739 --------QADALADSVKA--CGAEAL-------TLLCQL---------KEQESMGAADCSRLRT 777

  Fly   867 KLRDIEKLIEKIK-ASFE-QKIDLDKLLEIELREMDAAIDDAASKITDLLAKAREKDNQTNLEVN 929
            .|..::.|.||:: ...| |:.:|..|:|.|:....||::.||::|.::|.|:|..|....:|||
Zfish   778 ALDSVKALGEKLRPRGLELQQGELGDLVEQEMAATSAAVESAAARIEEMLNKSRAVDTGIKMEVN 842

  Fly   930 GKIVDACTTLMECVKALIQKSRLLQHEIVASQKGNASANEFYRRNSQWSDGLISASKSVAKAANY 994
            .:|:.:||.||:.::.|:..|:.||.:||.|.:|.||..|||.:||:|::|||||||:|...|..
Zfish   843 ERILASCTDLMQAIRVLVLSSKDLQRDIVESGRGAASMKEFYAKNSRWTEGLISASKAVGWGATM 907

  Fly   995 LVEAANKAIESESGKNFELIVAAQEIAACTTQMVIASKVKAERNSQKLTDLTKASRSVTQATGTL 1059
            ||:||::.::.: ||..||:|.:.||||.|.|:|.|||||||:.|..|:.|.:||:.|||||..:
Zfish   908 LVDAADQVVQGK-GKFEELMVCSHEIAASTAQLVAASKVKAEKGSSNLSRLQQASKGVTQATAGV 971

  Fly  1060 VATVKDCNSQLEQQSEIELSKLTPSQIKTMEMEIHVKVLEIEQALQMQRLKLSSFRKEHYKNA 1122
            ||:.|...||:|....::.|.:|.:|||..||:..|.|||:|..||.:|.:|...||:||:.|
Zfish   972 VASTKSGKSQIEDTETMDFSAMTLTQIKRQEMDAQVLVLELETRLQKERERLGELRKKHYELA 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	9..281	CDD:284961	124/273 (45%)
		TMPIT	402..>504	CDD:285135	20/102 (20%)
		I_LWEQ	973..1120	CDD:279885	70/146 (48%)
hip1	XP_005157489.1	ANTH	40..308	CDD:284961	123/267 (46%)
		RILP-like	<377..489	CDD:304877	30/115 (26%)
		CEP63	383..642	CDD:293650	74/370 (20%)
		HIP1_clath_bdg	483..581	CDD:293123	29/149 (19%)
		ILWEQ	836..1034	CDD:214607	92/198 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581431
Domainoid	1	1.000	240	1.000	Domainoid score	I2216
eggNOG	1	0.900	-	-		E1_KOG0980
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1579
OMA	1	1.010	-	-		QHG55957
OrthoDB	1	1.010	-	-		D104219at2759
OrthoFinder	1	1.000	-	-		FOG0002012
OrthoInspector	1	1.000	-	-		otm26536
orthoMCL	1	0.900	-	-		OOG6_102577
Panther	1	1.100	-	-	LDO	PTHR10407
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1344
SonicParanoid	1	1.000	-	-		X1787
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800