Protein Alignment Hip1 and hip1

DIOPT Version :10

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_005157489.1
• Gene: hip1 / 793823
• ZFINID: ZDB-GENE-010328-15
• Length: 1048
• Species: Danio rerio
• Alignment Length: 1169
• Identity: 367/1169 - (31%)
• Similarity: 566/1169 - (48%)
• Gaps: 218/1169 - (18%)

  Fly     6 EKEFYHLN--VSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKFS 68
            |||.:..|  ||::||:|..|..:|.||||:.|:..|..|.|.|||:.::|.||..:....|||.
Zfish    32 EKENFERNQAVSINKAINTQEVAVKEKHARTCILGTHHEKGAHTFWLAVNRLPLSSNAVLCWKFC 96

  Fly    69 HLLHKVLREGHESAIRHSQSHKKMILEVGKMWGLLQDDIGCCIQAYSKLLATKLNFHDKNRMFPG 133
            |:.||:||:||.:.|:.|..||..:.::.:|||.|.:..|.....|.|||.||:.||.||..|||
Zfish    97 HVFHKLLRDGHPNVIKDSMRHKADLNDMSRMWGHLSEGYGKLCSIYLKLLITKMEFHIKNPRFPG 161

  Fly   134 TLNISFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPIV 198
            .|.:|..:|..|.:.|:|..|||.||:|||||..:.|.|.:|||::..|..|:|..|||||||::
Zfish   162 NLQMSNRQLDEAGENDVNNFFQLTVEMFDYLECELNLFLGVFSSLDMSRSVSVTAAGQCRLAPLI 226

  Fly   199 CLIQDSNALYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPEL 263
            .:|.||:.|||.:|:|:||||..:|.|.:.||||||...|.||||.:.....|||||.||.||:|
Zfish   227 QVILDSSHLYDYTVKLLFKLHSCLPADTLQGHRDRFQEQFKKLKSLFYRSSNLQYFKRLIQIPQL 291

  Fly   264 PDSSPNFKSQNDFTSYVPPVVHVP-----QEPDPVV--EDLVDTNNHELEAFSQAQ--------- 312
            |::.|||...:..:.::.|||.:|     .|.:.||  ||||||:...|.....::
Zfish   292 PENPPNFLRASALSEHISPVVVIPAEASSPESEHVVETEDLVDTDIPPLTGTGDSKFDDLFGTSA 356

  Fly   313 --------QQLSMLEGIISEKEASIEELSFKLDAMQKNFDA-------LQQSYRHDVQELQ---Q 359
                    .|..|.:   .:|:..||:|:.:|.|:::..::       |.|:.|..|.||:   .
Zfish   357 ATDPFNFNSQNGMRK---DDKDRLIEQLTAELQALKEELESFRLESGRLCQALRGRVNELEAELA 418

  Fly   360 NNTVLSNDLVLAREMCATFRMQNDDLEMQLNQNPILLQKAMEE-EEKHKLSSEKFNKLKTLYTKI 423
            ..|.|....:...|.   .|.:.|||. ::.::....|:::.| |.|.:.:.:::.|||..||::
Zfish   419 EQTHLKQQALGESEF---LRAELDDLR-RVKEDTEKEQRSLSEIERKAQANEQRYTKLKEKYTEL 479

  Fly   424 RDEHIQLLREQSDCNKSLNKEKQVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKE 488
            ...|..|||:.:                     |:|.:::..:...:|
Zfish   480 VQSHADLLRKNA---------------------EVTRQMTVARAAQDE----------------- 506

  Fly   489 KIAHLEAVKNEMKEKF---DDVVKQKEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLSNAE 550
                :|.||.||:::.   .|...|:|..:|:        :|..|:.|.::....  ||.|.:..
Zfish   507 ----VENVKKEMQDRLKVAQDSASQQEKAQLE--------QLQALQAELMSSRTE--LETLKSTV 557

  Fly   551 SQINAKTEDIEKMLKAFEAEKALLLTQIEQQSVESKSHSEAQNAQLQEIMDNLEQKDKEFNEVKL 615
            :......|.:...|.|..||||.|:..:.::.||    .....|:|:.:..:|..
Zfish   558 TSSQQSNEQLGTQLSALVAEKAGLVETVSRKEVE----LSGLGAELERLQSSLTN---------- 608

  Fly   616 QLSSAESQISLKALEIQNNLKAFEAEKSVLLTKIEQLGIEHKNNSEAQNAQLQLTLNNLEQNESA 680
                          |.::.:||.||                          ||..||..|..|.|
Zfish   609 --------------ERESGVKAAEA--------------------------LQNQLNEKESREQA 633

  Fly   681 LQQTQEIVN----QLRQENASAGQRNEDLQSKLSLTEVKLTQATQQIDAVTSSYQICSTDLSELR 741
            |:  .|:|:    .||.....||:..:|  |...|.:......|...|.:.|..|:....:..||
Zfish   634 LE--SELVSLRWASLRAALEEAGKIVQD--SLNQLEDPAHISCTSSADYLVSRCQVALDCVERLR 694

  Fly   742 KLVIKTVKEICNSKLSGSEQQPLDAVPNIIREMETILNKFNN----ASAINYVASTEGLQNVMYL 802
            ......|.:  |:.:||           ::|.:....:...:    .||.:::...|
Zfish   695 SSRDGFVSD--NTDVSG-----------LVRAVTQFAHLVGDVIVQGSATSHMVPVE-------- 738

  Fly   803 GYVFIKLYDQCDVIYKTTTAIETGQEIFSKTNLLCTDICQLFQYLLNNETKEPERQ--KTITDIQ 865
                     |.|.:..:..|  .|.|..       |.:|||         ||.|..  ...:.::
Zfish   739 ---------QADALADSVKA--CGAEAL-------TLLCQL---------KEQESMGAADCSRLR 776

  Fly   866 TKLRDIEKLIEKIK-ASFE-QKIDLDKLLEIELREMDAAIDDAASKITDLLAKAREKDNQTNLEV 928
            |.|..::.|.||:: ...| |:.:|..|:|.|:....||::.||::|.::|.|:|..|....:||
Zfish   777 TALDSVKALGEKLRPRGLELQQGELGDLVEQEMAATSAAVESAAARIEEMLNKSRAVDTGIKMEV 841

  Fly   929 NGKIVDACTTLMECVKALIQKSRLLQHEIVASQKGNASANEFYRRNSQWSDGLISASKSVAKAAN 993
            |.:|:.:||.||:.::.|:..|:.||.:||.|.:|.||..|||.:||:|::|||||||:|...|.
Zfish   842 NERILASCTDLMQAIRVLVLSSKDLQRDIVESGRGAASMKEFYAKNSRWTEGLISASKAVGWGAT 906

  Fly   994 YLVEAANKAIESESGKNFELIVAAQEIAACTTQMVIASKVKAERNSQKLTDLTKASRSVTQATGT 1058
            .||:||::.::.: ||..||:|.:.||||.|.|:|.|||||||:.|..|:.|.:||:.|||||..
Zfish   907 MLVDAADQVVQGK-GKFEELMVCSHEIAASTAQLVAASKVKAEKGSSNLSRLQQASKGVTQATAG 970

  Fly  1059 LVATVKDCNSQLEQQSEIELSKLTPSQIKTMEMEIHVKVLEIEQALQMQRLKLSSFRKEHYKNA 1122
            :||:.|...||:|....::.|.:|.:|||..||:..|.|||:|..||.:|.:|...||:||:.|
Zfish   971 VVASTKSGKSQIEDTETMDFSAMTLTQIKRQEMDAQVLVLELETRLQKERERLGELRKKHYELA 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	11..278	CDD:400137	124/268 (46%)
		Mplasa_alph_rch	<312..783	CDD:275316	98/505 (19%)
		EnvC	662..>909	CDD:443969	58/258 (22%)
		ILWEQ	924..1122	CDD:214607	92/197 (47%)
hip1	XP_005157489.1	ANTH	40..306	CDD:400137	123/265 (46%)
		Smc	<370..>825	CDD:440809	127/619 (21%)
		HIP1_clath_bdg	483..581	CDD:465154	29/149 (19%)
		ILWEQ	836..1034	CDD:214607	92/198 (46%)