Protein Alignment Hip1 and hip1rb

DIOPT Version :9

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_001077034.2
• Gene: hip1rb / 562138
• ZFINID: ZDB-GENE-070209-59
• Length: 1065
• Species: Danio rerio
• Alignment Length: 1186
• Identity: 331/1186 - (27%)
• Similarity: 545/1186 - (45%)
• Gaps: 257/1186 - (21%)

  Fly     5 AEKEFYHLN--VSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKF 67
            ||:|.:...  .|:|||:|..|.|||.||||.||:..|:.|.|.|||......||..|...:|||
Zfish    22 AEREHFEKQQLSSISKAINSTETPLKEKHARRIILGTHREKGAYTFWSYAVGLPLPSSAILSWKF 86

  Fly    68 SHLLHKVLREGHESAIRHSQSHKKMILEVGKMWGLLQDDIG--CCIQAYSKLLATKLNFHDKNRM 130
            .|:|||:||:||.:.::....|...|.|.|.:|...:|..|  ..:..::|||.||:.||.|:..
Zfish    87 CHVLHKILRDGHRNTLQDCMRHYSDIAETGLLWTNTRDRHGYALLVSLHAKLLCTKIEFHTKHSE 151

  Fly   131 FPGTLNISFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLA 195
            .|.:|.::...|......|:|..|||.||:|||::..:.|...:...:......|....|||:||
Zfish   152 IPASLEVTDELLERTAGTDINNVFQLTVEVFDYMDAELRLAEAVLHQLNMSIAISTLTSGQCKLA 216

  Fly   196 PIVCLIQDSNALYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITI 260
            |::.:|||.:.||..:|:|:||||..:|.|.:.|||:|||..|..||:|.|..|.:.|||.||.|
Zfish   217 PLIQVIQDCSHLYHYTVKLLFKLHACLPADTLQGHRERFHDQFHSLKTFLNKARDMLYFKRLIQI 281

  Fly   261 PELPDSSPNFKSQNDFTSYVPPVVHVP----------QEPDPVVE-------------------- 295
            |.||||.|||...:....:|.|:|.:|          .||:|:::
Zfish   282 PRLPDSPPNFLRASALAEHVKPMVVIPDEEELEEQEEDEPEPLIDVSEALPVAASQPLQSDIFDQ 346

  Fly   296 ------DLVDTNNHELEAFSQAQQQL-SMLEGIISEKEASIEELSFKLDAMQKNFDALQQSYRHD 353
                  |..|..:.::|...:..:.| :.||.|..|.:..|.:|..::::::...:.
Zfish   347 AFGPPKDGFDDRDLQIERLKREIELLQAELEKIKGEAQRYITQLKAQINSLEGELEE-------- 403

  Fly   354 VQELQQNNTVLSNDLVLAREMCATFRMQNDDLEMQLNQNPILLQKAMEEEEKHKLSSEKFNKLKT 418
             |.:|:..|::.|: .|..|:.||.|...:...||.|        .:|.|::.:.:..::||||.
Zfish   404 -QRMQKQRTLVENE-QLRMELEATHRRNTEHESMQTN--------FVETEKRAQATELRYNKLKE 458

  Fly   419 LYTKIRDEHIQLLREQSDCNKSLNKEKQVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQI 483
            .:.::...|.:|||:.:|..|.|:..:|.                                |::|
Zfish   459 KHAELVANHAELLRKSADTVKMLSATQQT--------------------------------QEEI 491

  Fly   484 EEHKEKIA-HLEAVKNEMKEKFDDVVKQKEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLS 547
            |..|:::| .::.||.|...|||:       |:.:                         ::||
Zfish   492 ERTKQQLAFEVDRVKQESDMKFDE-------QKFE-------------------------MDKL- 523

  Fly   548 NAESQINAKTEDIEKMLKAFEAEKALLLTQIEQQSVESKSHSEAQNAQLQEIMDNLEQKDKEFNE 612
              :.::.||..:|:|:..:.:..        |...|...|...|..|:...:..::.:||.|.:.
Zfish   524 --KRELEAKAAEIQKVRSSLQTS--------EMTGVHMNSSMAALQAEKDRLTQSISKKDAELSS 578

  Fly   613 VKLQLSSAESQISLKALEIQNNLKAFEAEKSVLLTKIEQLGIEHKNNSEAQNAQLQLTLNNLEQN 677
            :|     .|||:...:|:                                            ::.
Zfish   579 LK-----KESQLKESSLQ--------------------------------------------QER 594

  Fly   678 ESALQQTQEIVNQLRQENASAGQRNEDLQSKLSLTEVKLTQATQQIDAVTSSYQI---------- 732
            :..:::.:|:..:|:::.:    |.|.||.||...:..|.|||     ||.:..|
Zfish   595 DRTIRELEELQGKLKEKLS----REEQLQQKLLDEQFTLLQAT-----VTEAENIIQDAVAKLDD 650

  Fly   733 -----CSTDLSELRKLVIKTVKEICNSKLSGSEQ-QPLDAVPNIIREM--------ETILNKFNN 783
                 ||:....|......|:..:...:...||. :.:.....::|.:        :||:    |
Zfish   651 PIHISCSSSPDYLISRAEATLGSVEKVQAGHSEYVKSMKDAGGLVRALTMFSHLAADTII----N 711

  Fly   784 ASAINYVASTEGLQNVMYLGYVFIKLYDQCDVIYKTTTAIETGQEIFSKTNLLCTDICQLFQYLL 848
            .||..::|.|:...          :|.:||.                     .|.  .|..|||.
Zfish   712 GSATAHMAPTDHAD----------RLTEQCK---------------------SCA--TQSLQYLK 743

  Fly   849 NNETKEPERQKTITDIQTKLRDIEKLIEKI--KASFEQKIDLDKLLEIELREMDAAIDDAASKIT 911
            :.::|...|....|.||..::.|.::.:.:  |.....|.:|..:::.|:....|||::|..:|.
Zfish   744 SLKSKASLRGADPTAIQAAVQKILRIGKDLRPKGLDVGKDELGDMVDKEMAATSAAIEEAVRRID 808

  Fly   912 DLLAKAREKDNQTNLEVNGKIVDACTTLMECVKALIQKSRLLQHEIVASQKGNASANEFYRRNSQ 976
            :::::.|:......||||.:|:::||.||:.::.|:..|..||.|||...:|.||..|||.|||:
Zfish   809 EMMSQTRKDATGVQLEVNERILNSCTDLMQAIRLLVLASTDLQKEIVEGGRGAASVREFYARNSR 873

  Fly   977 WSDGLISASKSVAKAANYLVEAANKAIESESGKNFELIVAAQEIAACTTQMVIASKVKAERNSQK 1041
            |::|||||||:|...|..:|::|:|.: ..:||..||||.:.||||.|.|:|.||||||:|.|::
Zfish   874 WTEGLISASKAVGWGATQMVDSADKVV-LHTGKYEELIVCSHEIAASTAQLVAASKVKADRGSKR 937

  Fly  1042 LTDLTKASRSVTQATGTLVATVKDCNSQLEQQSEIELSKLTPSQIKTMEMEIHVKVLEIEQALQM 1106
            |.:|.:|||.|.:....:||:.|....|:|.:..::.|.|:..::|..|||..|||||:|..|:.
Zfish   938 LGNLQQASRHVNEMAAKVVASTKTGQDQVEDKDTMDFSGLSLIKLKKEEMESQVKVLELETMLEN 1002

  Fly  1107 QRLKLSSFRKEHYKNA 1122
            :||:|...||:||:.|
Zfish  1003 ERLRLGELRKKHYEIA 1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	9..281	CDD:284961	110/275 (40%)
		TMPIT	402..>504	CDD:285135	21/102 (21%)
		I_LWEQ	973..1120	CDD:279885	67/146 (46%)
hip1rb	NP_001077034.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581430
Domainoid	1	1.000	240	1.000	Domainoid score	I2216
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1579
OMA	1	1.010	-	-		QHG55957
OrthoDB	1	1.010	-	-		D104219at2759
OrthoFinder	1	1.000	-	-		FOG0002012
OrthoInspector	1	1.000	-	-		otm26536
orthoMCL	1	0.900	-	-		OOG6_102577
Panther	1	1.100	-	-	O	PTHR10407
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1787
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910