Protein Alignment Hip1 and HIP1

DIOPT Version :9

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_005329.3
• Gene: HIP1 / 3092
• HGNCID: 4913
• Length: 1037
• Species: Homo sapiens
• Alignment Length: 1159
• Identity: 345/1159 - (29%)
• Similarity: 552/1159 - (47%)
• Gaps: 218/1159 - (18%)

  Fly     5 AEKEFYH--LNVSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKF 67
            ||:|.:.  ..||::||:|..|..:|.||||:.|:..|..|.|:|||.:::|.||..:....|||
Human    31 AERESFERTQTVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKF 95

  Fly    68 SHLLHKVLREGHESAIRHSQSHKKMILEVGKMWGLLQDDIGCCIQAYSKLLATKLNFHDKNRMFP 132
            .|:.||:||:||.:.::.|..::..:.::.:|||.|.:..|.....|.|||.||:.:|.||..||
Human    96 CHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFP 160

  Fly   133 GTLNISFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPI 197
            |.|.:|..:|..|.:.|:|..|||.||:|||||..:.|..|:|:|::..|..|:|..|||||||:
Human   161 GNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPL 225

  Fly   198 VCLIQDSNALYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPE 262
            :.:|.|.:.|||.:|:|:||||..:|.|.:.||||||...|.|||..:.....|||||.||.||:
Human   226 IQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQ 290

  Fly   263 LPDSSPNFKSQNDFTSYVPPVVHVPQE---PD--PVVE--DLVDTNNHEL------------EAF 308
            ||::.|||...:..:.::.|||.:|.|   ||  ||:|  ||:|.:..:.            .:|
Human   291 LPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSF 355

  Fly   309 SQAQQQLSMLEGI-ISEKEASIEELSFKLDAMQKNFDALQQSYRHDVQELQQNNTVLSNDLV--- 369
            |......:...|: ..||:..||.|..::..::...:.::...:..|.:|:.:.:.|..||.
Human   356 SSDPFNFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQ 420

  Fly   370 ----LAREMCATFRMQNDDLEMQLNQNPILLQKAMEEEEKHKLSSEKFNKLKTLYTKIRDEHIQL 430
                .|.:.|...|.:.|:|..|........:...|.|.|.:.:.::::|||..|:::...|..|
Human   421 HLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADL 485

  Fly   431 LREQSDCNKSLNKEKQVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKEKIAHLEA 495
            ||:.::..|.::..:|....|..|.|||.:.:.:|....:.|      .|:|:|.       ||:
Human   486 LRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRK------TQEQLEV-------LES 537

  Fly   496 VKNEMKEKFDDVVKQKEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLSNAESQINAKTEDI 560
            :|.|:      ...|:|:|.                       |..:||..:.:|:...|:..::
Human   538 LKQEL------ATSQRELQV-----------------------LQGSLETSAQSEANWAAEFAEL 573

  Fly   561 EKMLKAFEAEKALLLTQIEQQS-VESKSHSEAQNAQLQEIMDNLEQKDKEFNEVKLQLSSAESQI 624
            ||                |:.| |...:|.|.:.:.|:          ||..:.:|:|:|.|..:
Human   574 EK----------------ERDSLVSGAAHREEELSALR----------KELQDTQLKLASTEESM 612

  Fly   625 SLKALEIQNNLKAFEAEKSVLLTKIEQLGIEHKNNSEAQNAQLQLTLNNLEQNESALQQTQEIVN 689
            ...|.:          ::.:||                           :...::|.|..|:.:|
Human   613 CQLAKD----------QRKMLL---------------------------VGSRKAAEQVIQDALN 640

  Fly   690 QLRQEN--ASAGQRNEDLQSKLSLTEVKLTQATQQIDAVTSSYQICSTDLSELRKLVIKTVKEIC 752
            ||.:..  :.||..:.     |..|...::...:|::...|.|..|..|:|.|.. .|..:..:.
Human   641 QLEEPPLISCAGSADH-----LLSTVTSISSCIEQLEKSWSQYLACPEDISGLLH-SITLLAHLT 699

  Fly   753 NSKLSGSEQQPLDAVPNIIREMETILNKFNNASAINYVASTEGLQNVMYLGYVFIKLYDQCDVIY 817
            :..::......|.|.|.....:.....::.. ..:.|:||.|
Human   700 SDAIAHGATTCLRAPPEPADSLTEACKQYGR-ETLAYLASLE----------------------- 740

  Fly   818 KTTTAIETGQEIFSKTNLLCTDICQLFQYLLNNETKEPERQKTITDIQTKLRDIEKLIEKIKASF 882
                  |.|.                    |.|..            .|.:|:   .:.||||..
Human   741 ------EEGS--------------------LENAD------------STAMRN---CLSKIKAIG 764

  Fly   883 EQKI---------DLDKLLEIELREMDAAIDDAASKITDLLAKAREKDNQTNLEVNGKIVDACTT 938
            |:.:         :|..|::.|:....|||:.|.::|.::|:|:|..|....||||.:|:..||:
Human   765 EELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTS 829

  Fly   939 LMECVKALIQKSRLLQHEIVASQKGNASANEFYRRNSQWSDGLISASKSVAKAANYLVEAANKAI 1003
            ||:.::.||..|:.||.|||.|.:|.||..|||.:||:|::|||||||:|...|..:|:||:..:
Human   830 LMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVV 894

  Fly  1004 ESESGKNFELIVAAQEIAACTTQMVIASKVKAERNSQKLTDLTKASRSVTQATGTLVATVKDCNS 1068
            :.. ||..||:|.:.||||.|.|:|.||||||:::|..|..|.:|||.|.|||..:||:.....|
Human   895 QGR-GKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKS 958

  Fly  1069 QLEQQSEIELSKLTPSQIKTMEMEIHVKVLEIEQALQMQRLKLSSFRKEHYKNA 1122
            |:|:...::.|.:|.:|||..||:..|:|||:|..||.:|.||...||:||:.|
Human   959 QIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELA 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	9..281	CDD:284961	116/273 (42%)
		TMPIT	402..>504	CDD:285135	26/101 (26%)
		I_LWEQ	973..1120	CDD:279885	68/146 (47%)
HIP1	NP_005329.3	ANTH	39..308	CDD:311541	116/268 (43%)
		SMC_N	<369..644	CDD:330553	74/379 (20%)
		pDED	410..491		20/80 (25%)
		HIP1_clath_bdg	482..580	CDD:318670	31/155 (20%)
		ILWEQ	814..1012	CDD:214607	93/198 (47%)
		Important for actin binding. /evidence=ECO:0000250	867..924		28/57 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1017..1037

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147622
Domainoid	1	1.000	237	1.000	Domainoid score	I2323
eggNOG	1	0.900	-	-		E1_KOG0980
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1754
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55957
OrthoDB	1	1.010	-	-		D104219at2759
OrthoFinder	1	1.000	-	-		FOG0002012
OrthoInspector	1	1.000	-	-		otm42173
orthoMCL	1	0.900	-	-		OOG6_102577
Panther	1	1.100	-	-	LDO	PTHR10407
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1344
SonicParanoid	1	1.000	-	-		X1787
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800