Protein Alignment Hip1 and Hip1

DIOPT Version :9

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_036020878.1
• Gene: Hip1 / 215114
• MGIID: 1099804
• Length: 1037
• Species: Mus musculus
• Alignment Length: 1151
• Identity: 348/1151 - (30%)
• Similarity: 569/1151 - (49%)
• Gaps: 202/1151 - (17%)

  Fly     5 AEKEFYH--LNVSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKF 67
            ||:|.:.  ..|||:||:|..|..:|.||||:.|:..|..|.|:|||.:::|.||..:....|||
Mouse    31 AERESFERTQTVSVNKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAMLCWKF 95

  Fly    68 SHLLHKVLREGHESAIRHSQSHKKMILEVGKMWGLLQDDIGCCIQAYSKLLATKLNFHDKNRMFP 132
            .|:.||:||:||.:.::.|..:|..:.::.:|||.|.:..|.....|.|||.|::.:|.||..||
Mouse    96 CHVFHKLLRDGHPNVLKDSLRYKNELSDMSRMWGHLSEGYGQLCSIYLKLLRTRMEYHTKNPRFP 160

  Fly   133 GTLNISFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPI 197
            |.|.:|..:|..|.:.|:|..|||.||:|||||..:.|..|:|:|::..|..|:|..|||||||:
Mouse   161 GNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTTAGQCRLAPL 225

  Fly   198 VCLIQDSNALYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPE 262
            :.:|.|.:.|||.:|:|:||||..:|.|.:.||||||...|.|||..:.....|||||.||.||:
Mouse   226 IQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFQRSSNLQYFKRLIQIPQ 290

  Fly   263 LPDSSPNFKSQNDFTSYVPPVVHVPQE---PD--PVVE--DLVDTNNHELEAF------------ 308
            ||::.|||...:..:.::.|||.:|.|   ||  ||:|  ||:|.:..:...|
Mouse   291 LPENPPNFLRASALSEHISPVVVIPAEVSSPDSEPVLEKDDLMDMDASQQTLFDNKFDDVFGSSL 355

  Fly   309 SQAQQQLSMLEGI-ISEKEASIEELSFKLDAMQKNFDALQQSYRHDVQELQQNNTVLSNDLV--- 369
            |......:...|: ..||:..||.|..::..:....|.::...:..:.:|:...:.|..:|.
Mouse   356 SSDPFNFNNQNGVNKDEKDHLIERLYREISGLTGQLDNMKIESQRAMLQLKGRVSELEAELAEQQ 420

  Fly   370 -LAREM---CATFRMQNDDLEMQLNQNPILLQKAMEEEEKHKLSSEKFNKLKTLYTKIRDEHIQL 430
             |.|:.   |...|.:.|:|:.|........:...|.|.|.:.:.::::|||..|:::...|..|
Mouse   421 HLGRQAMDDCEFLRTELDELKRQREDTEKAQRSLTEIERKAQANEQRYSKLKEKYSELVQNHADL 485

  Fly   431 LREQSDCNKSLNKEKQVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKEKIAHLEA 495
            ||:.::..|.::..:|....|..|.|||.:..:::....          |::.:|.::.   ||.
Mouse   486 LRKNAEVTKQVSVARQAQVDLEREKKELADSFARVSDQA----------QRKTQEQQDV---LEN 537

  Fly   496 VKNEMKEKFDDVVKQKEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLSNAESQINAKTEDI 560
            :|:|:      ...::|:|.|.                             ||.|:  :|::|
Mouse   538 LKHEL------ATSRQELQVLH-----------------------------SNLET--SAQSE-- 563

  Fly   561 EKMLKAFEAEKALLLTQIEQQSVESKSHSEAQNAQLQEIMDNLEQKDKEFNEVKLQLSSAESQIS 625
                       |..||||.:  :|.:..|.|..|         .|:::|.:.::.||.|  :||.
Mouse   564 -----------AKWLTQIAE--LEKEQGSLATVA---------AQREEELSALRDQLES--TQIK 604

  Fly   626 LKALEIQNNLKAFEAEKSVLLTKIEQLGIEHKNNSEAQNAQLQLTLNNLEQNESALQQTQEIVNQ 690
            |...: ::..:..:.::..||..|                           .::|.::.||.::|
Mouse   605 LAGAQ-ESMCQQVKDQRKTLLAGI---------------------------RKAAEREIQEALSQ 641

  Fly   691 LRQEN-ASAGQRNEDLQSKLSLTEVKLTQATQQIDAVTSSYQICSTDLSELRKLVIKTVKEICNS 754
            |.:.. .|.....:.|.||:|    .::...:|::...|.|..|..|:|||    :.::..:.:
Mouse   642 LEEPTLISCAGSTDHLLSKVS----SVSSCLEQLEKNGSQYLACPEDISEL----LHSITLLAH- 697

  Fly   755 KLSGSEQQPLDAVPNIIREMETILNKFNNASAINYVASTEGLQNVMYLGYVFIKLYDQCDVIYKT 819
             |:|                :||:    ..||.:..|..|...::                   |
Mouse   698 -LTG----------------DTII----QGSATSLRAPPEPADSL-------------------T 722

  Fly   820 TTAIETGQEIFSKTNLLCTDICQLFQYLLNNETKEPERQKTITDIQTKLRDIEKLIEKI---KAS 881
            ....:.|:|..:              ||.:.|.:.......:|.::..|..::.|.|::   ...
Mouse   723 EACRQYGRETLA--------------YLSSLEEEGTMENADVTALRNCLSRVKTLGEELLPRGLD 773

  Fly   882 FEQKIDLDKLLEIELREMDAAIDDAASKITDLLAKAREKDNQTNLEVNGKIVDACTTLMECVKAL 946
            .:|: :|..|::.|:....|||:.|.::|.::|:|:|..|....||||.:|:.:||:||:.:|.|
Mouse   774 IKQE-ELGDLVDKEMAATSAAIEAATTRIEEILSKSRAGDTGVKLEVNERILGSCTSLMQAIKVL 837

  Fly   947 IQKSRLLQHEIVASQKGNASANEFYRRNSQWSDGLISASKSVAKAANYLVEAANKAIESESGKNF 1011
            :..|:.||.|||.|.:|.||..|||.:||:|::|||||||:|...|..:|:||:..::.: ||..
Mouse   838 VVASKDLQKEIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATIMVDAADLVVQGK-GKFE 901

  Fly  1012 ELIVAAQEIAACTTQMVIASKVKAERNSQKLTDLTKASRSVTQATGTLVATVKDCNSQLEQQSEI 1076
            ||:|.::||||.|.|:|.||||||.:.|..||.|.:|||.|.|||..:||:.....||:|:...:
Mouse   902 ELMVCSREIAASTAQLVAASKVKANKGSLNLTQLQQASRGVNQATAAVVASTISGKSQIEETDSM 966

  Fly  1077 ELSKLTPSQIKTMEMEIHVKVLEIEQALQMQRLKLSSFRKEHYKNA 1122
            :.|.:|.:|||..||:..|:|||:|..||.:|.||...||:||:.|
Mouse   967 DFSSMTLTQIKRQEMDSQVRVLELENDLQKERQKLGELRKKHYELA 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	9..281	CDD:284961	117/273 (43%)
		TMPIT	402..>504	CDD:285135	23/101 (23%)
		I_LWEQ	973..1120	CDD:279885	69/146 (47%)
Hip1	XP_036020878.1	ANTH	39..306	CDD:400137	117/266 (44%)
		Smc	389..>644	CDD:224117	53/261 (20%)
		HIP1_clath_bdg	488..580	CDD:406822	12/91 (13%)
		ILWEQ	814..1012	CDD:214607	57/200 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837700
Domainoid	1	1.000	239	1.000	Domainoid score	I2271
eggNOG	1	0.900	-	-		E1_KOG0980
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1729
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55957
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002012
OrthoInspector	1	1.000	-	-		otm44226
orthoMCL	1	0.900	-	-		OOG6_102577
Panther	1	1.100	-	-	LDO	PTHR10407
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1344
SonicParanoid	1	1.000	-	-		X1787
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.790