DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip1 and tag-138

DIOPT Version :9

Sequence 1:	NP_648597.2	Gene:	Hip1 / 39450	FlyBaseID:	FBgn0036309	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_493260.1	Gene:	tag-138 / 184169	WormBaseID:	WBGene00006484	Length:	362	Species:	Caenorhabditis elegans

Alignment Length:	364	Identity:	105/364 - (28%)
Similarity:	168/364 - (46%)	Gaps:	58/364 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKFSHLLHKVLREGH 79
            :|.||:...|.|||.||..:|::..|..|.:..||..:.:..|.......|||..|:||:||:||
Worm    13 AVQKAITKDETPLKPKHLETILLGTHTEKSSAIFWSSVKKIKLENHPVLTWKFCLLVHKLLRDGH 77

  Fly    80 ESAIRHSQSHKKMILEVGKMWGLLQD--DIGCCIQAYSKLLATKLNFHDKNRMFPGTLNISFTEL 142
            ....:.:..::|...::...|   :|  |.|.||.||.|||..::.||.|...|||.|.:|..:|
Worm    78 PVVPKEAYRNEKRFTQLALHW---KDKRDYGPCIDAYCKLLHDRVIFHHKRPYFPGNLFVSPLQL 139

  Fly   143 FIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIF-SSMEKYRMSSMTPQGQCRLAPIVCLIQDSNA 206
             ..:.|||:...:|..::...::.::|.|..:: .|....|....||||||.:.|::.:|.|:..
Worm   140 -DTMGRDLSRMLRLTGDMMHQMDSLLAFQEKVYLLSNSSPRWDPNTPQGQCLMLPLISVIMDTWP 203

  Fly   207 LYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPELPDSSPNFK 271
            .:...||:|:.||..|....:.|:|.||..:|.|.|.||......|||:..:.||..|..:|||.
Worm   204 FFIYIVRMMYNLHSNVSPHELEGYRSRFQTIFEKTKQFYEECSKHQYFRCFVQIPTFPLHAPNFF 268

  Fly   272 SQNDFTSY--------------VPPV---------------------VHVPQEPDPVVEDLVDTN 301
            :|:|..||              |.|.                     .||.:|        .|.|
Worm   269 TQSDLESYQTYLIGESKKLTETVTPAEEARTRIEHYENRLKEMHGEFQHVRRE--------ADEN 325

  Fly   302 NHELEAFSQAQQQLSMLEGIISEKEASI-----EELSFK 335
            ..|::   :.:.:|::.:...::.:|:|     :|.|.|
Worm   326 REEVQ---RLRYELALRDASRTQNQAAIYDTPPDEFSIK 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	9..281	CDD:284961	91/282 (32%)
		TMPIT	402..>504	CDD:285135
		I_LWEQ	973..1120	CDD:279885
tag-138	NP_493260.1	ANTH	13..276	CDD:336756	89/266 (33%)
tag-138	NP_493260.1	GrpE	<295..>333	CDD:383227	6/48 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159607
Domainoid	1	1.000	206	1.000	Domainoid score	I1699
eggNOG	1	0.900	-	-		E1_KOG0980
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D104219at2759
OrthoFinder	1	1.000	-	-		FOG0002012
OrthoInspector	1	1.000	-	-		otm14291
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1344
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.740