Protein Alignment LDHB and Ldh

DIOPT Version :10

• Sequence 1: XP_006719137.1
• Gene: LDHB / 3945
• HGNCID: 6541
• Length: 353
• Species: Homo sapiens
• Sequence 2: NP_476581.1
• Gene: Ldh / 45880
• FlyBaseID: FBgn0001258
• Length: 332
• Species: Drosophila melanogaster
• Alignment Length: 280
• Identity: 177/280 - (63%)
• Similarity: 232/280 - (82%)
• Gaps: 5/280 - (1%)

Human     1 MATLKEKLIAPVAEEEATVPN--NKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEM 63
            ||.:|:.|:|.|||   .:|:  :|:|:||:||||||.|.|||.::::.|:.|:||..|||:||:
  Fly     1 MAAIKDSLLAQVAE---VLPSSGHKVTIVGIGQVGMASAFSILAQNVSKEVCLIDVCADKLQGEL 62

Human    64 MDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKY 128
            |||||||.||:.|:|.|..|::.:|||::.:|||||||:||||||:|||||.::.|.|||::|:|
  Fly    63 MDLQHGSNFLKNPQITASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKNIIPKLVEY 127

Human   129 SPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGE 193
            |||.|:::|||||||:|||.||||||||:||||||.||||:|||:||:::||:.|:||||||:||
  Fly   128 SPDTILLMVSNPVDIMTYVAWKLSGLPKNRVIGSGTNLDSSRFRFLMSQRLGVAPTSCHGWIIGE 192

Human   194 HGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVA 258
            ||||||.||||||:|||.|:||||.:||..|.|.|.|:||.||:||||||||||||:||||||.|
  Fly   193 HGDSSVPVWSGVNIAGVRLRELNPILGTGEDPEKWNELHKQVVDSAYEVIKLKGYTSWAIGLSTA 257

Human   259 DLIESMLKNLSRIHPVSTMV 278
            .|..::|:|.|.:..|||.|
  Fly   258 SLASAILRNTSSVAAVSTSV 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LDHB	XP_006719137.1	LDH_1	20..279	CDD:133429	169/261 (65%)
Ldh	NP_476581.1	LDH_1	18..329	CDD:133429	168/260 (65%)