Protein Alignment Vps13D and Vps13b

DIOPT Version :9

• Sequence 1: NP_729825.2
• Gene: Vps13D / 39448
• FlyBaseID: FBgn0052113
• Length: 3919
• Species: Drosophila melanogaster
• Sequence 2: NP_796125.2
• Gene: Vps13b / 666173
• MGIID: 1916380
• Length: 3993
• Species: Mus musculus
• Alignment Length: 4718
• Identity: 848/4718 - (17%)
• Similarity: 1528/4718 - (32%)
• Gaps: 1696/4718 - (35%)

  Fly     1 MLRDLITWVLNTYLGKYLENLNSAQLSVALLSGEVELENIPIRKDAL-RSFNLPVEVTAGSIRKI 64
            ||...:|.:|.:|:.:|::||..:.|.::|..|:|.|..:.::.|.| :...||....:|.|.::
Mouse     1 MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHEL 65

  Fly    65 KLQIPVRQFRTSPWCISIEGLFCII------------CPKNLDNWDYEKEKLQDLEYKLAVLDTA 117
            ::.:|..:..:.|..|:|..:.||:            |..|..|                 ..||
Mouse    66 RIHVPWTKLGSEPVVITINTMECILKLKDGIQDDHESCGSNSTN-----------------RSTA 113

  Fly   118 EAGWRSEKGKQMESYYFSSYNNWLKYGTNMATNIIDNIELKISDVHFRF--EDIVDTGKSKICTG 180
            |....|.|.::::....:..:....|..::...:::|:.:.|:::..::  :|||
Mouse   114 ENTKSSIKPRRIQQAAPADPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIV---------- 168

  Fly   181 IKIGSLTAQSCDCDWTNGSYKMNNNEMNYKLVELKELSVYWDLLHEDI--------KCQSYSNQE 237
               .|:...|.:|               |.:.||      ||....||        |..::|:..
Mouse   169 ---LSVNITSAEC---------------YTVGEL------WDRAFMDISATDLVLRKAINFSDCT 209

  Fly   238 I-LEKMHSTCELRSHNFIIKPIC--ATARWKRDKCQQVIRTKDKPRVSCELLVPEVVIDISKVQR 299
            : |:|.:::.::   .|...|:.  .:.|.:.......:.:|....:....||..:.:.|:. |:
Mouse   210 VCLDKRNASGKI---EFYQDPLLYKCSFRTRLHFTYDNLNSKMPSVIKIHTLVESLKLSITD-QQ 270

  Fly   300 LQMLDKLSEIRQVKEVRQYRLKRPTCTVESNPIAWWKYATICHGFDFKKNEEKWLMLKENLRYML 364
            |.|..::.::                     .||.: |..| ..|...:.|:...:.|:.|..
Mouse   271 LPMFIRIMQL---------------------GIALY-YGEI-GNFKDGETEDPPCLSKDTLAN-- 310

  Fly   365 LYKSIILNPNENLSAADKEFKAYIESDRKISDLTIMRRICFEKVFTKGFAFESQNEQGKNMLFHW 429
                  |...|..|..|.::.|..:.               ::::::.:    :..||
Mouse   311 ------LTGTEEESRIDMQYPAPYKG---------------QELYSQDY----EEPQG------- 343

  Fly   430 FPNWMGW-YANSP---STPNNEQDE------SLKH------LEDDIL-----------------V 461
               |:.| ::..|   |..:.|:|:      |:.|      |:|.|:                 :
Mouse   344 ---WVSWAWSFVPAIVSYDDGEEDDLGTDPASIMHQQKAQTLKDPIVSVGFYCTKATVTFKLTEM 405

  Fly   462 ALENSLQNSSDLKS-----------------------DAVFGHFSIK--LLKGLV-ILQTEDKLN 500
            ..|||..:...:||                       |...|....:  .|||:: :...|:.:|
Mouse   406 QAENSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFVGCRAMCLKGILGVKDFEEHMN 470

  Fly   501 DGRNKSMEMQF---NNFSAYLQLSPQLTSYTVGISLQEVYLIDKTSSDTMHNYLIKPQTGNTATP 562
              |:::....|   .|.|            |.|::.....|.|..|.:            |..|.
Mouse   471 --RSETEACFFICGENLS------------TKGLTYLTNSLFDYRSPE------------NNGTR 509

  Fly   563 NQLVKNAALQEDILFQLQYENCNHLRFQLNIKSKGLDLIYNEDAIQWLLDFLADSNSFKYSPRNR 627
            .:.:.:||              :|       |....|:...:....:.:|:|   .:.::|....
Mouse   510 AEFILDAA--------------HH-------KETHTDIAGIQRFGAFYMDYL---YTVEHSSGKG 550

  Fly   628 VAKKTDFMKNWNEMFSGNEVNRKIWMFEIEIFAPRIIFLENYKVSNSLMVLLDFGKLEMR--KME 690
            ...:.||....||...                      :...|.:.||::    |.|:.|  ...
Mouse   551 PTSQQDFPSGKNEDLG----------------------IVQEKSTKSLVI----GPLDCRLDSSA 589

  Fly   691 VKRVIPVIESAVTENTSDDDETY--LTPCSTPPASEKSGSESPTLLENPKTESFLNKNVQLEYVL 753
            |.||:.:|..|:    ..:.|.|  |.|        :|..|..|:|: |:..|.|.:.:...:
Mouse   590 VHRVLKMIVCAL----EHEYEPYSRLKP--------ESKDEKETVLD-PEEVSSLEEYIPTRH-- 639

  Fly   754 HNKIYDKYLINFTNLQVLVCKYEERWQACLKTSSNFHLIDKFNINLTLEQRNIFTVDPEYPSFML 818
                        |::.:|.|       .|....:.|:|:|
Mouse   640 ------------TSVTLLKC-------TCTVFMAEFNLLD------------------------- 660

  Fly   819 FGTCPTILIHGNEELINNCCNIMKPIIKASKEMENIYRGGNTIYASER----IKNLAEDDRSRVV 879
                               |  :.|:|...|...|:....|  :.|.|    |:.|.:.......
Mouse   661 -------------------C--LLPVIMGGKNSSNVTNATN--FQSLRPLPSIQILVDKINLEHS 702

  Fly   880 IEFVMDQLVIEMQSTERSI----------AELQIIGARAGLTKEPHE----------TNISMSVH 924
            :....:|||..:.|..:..          ..|::.|.:||||...|.          .:.|.:::
Mouse   703 VPMYAEQLVHVVSSLNQPSDNLLHYCYVHCYLKVFGFQAGLTCLDHSGSYCLPAPIIPSFSTALY 767

  Fly   925 GLLL-------------------------VDAIQSFGPDFELLVASHRHVGMDSLSGSLKHSAIV 964
            |.||                         :.|.::.....:.:..|..|:|  ::|.|..:.|::
Mouse   768 GKLLKLPALWTKRSQTVVTEGIFELPNLTIQATRAQTLLLQAIYQSWSHIG--NVSSSTVNEALM 830

  Fly   965 S--------------PTSPGSPNFFDRATSPHMITKAVQNIKMGDRSTEFCDDEDSTALISVDIK 1015
            :              ||..||                :||:::     ::|    ||:|:.
Mouse   831 NEVFPMTGVKSKNPLPTLEGS----------------IQNVEL-----KYC----STSLVK---- 866

  Fly  1016 IVPPNESNSMQLHTTSITFNSLDIIA------NQDTIIEILNFAKRTL-LAQNIFPSES--PES- 1070
                         ..|.|..|:.|.|      .::.:|.:|.....|. |..:.:.:||  |||
Mouse   867 -------------CASGTLGSIKICAKAPGDSGKEKLIPLLQGPSDTRDLHSSKWLNESRKPESL 918

  Fly  1071 -PKEATEAPVDVVDQVDHKSHNEIFF----DFFRLNI-LLLYT------IKRDKFNVGRKVGTVT 1123
             ..:.....:.|...:|:..|:...|    ....:|| .:|||      .||...:..::.....
Mouse   919 LAPDLIAFTIQVPQYMDYCHHSGAVFLCSVQGLAVNIDPILYTWVIYQPQKRANRHAQQQPVVAV 983

  Fly  1124 LTEAKINASFQSDLSI----IGSLGGIQVID-----ITSEAFCHPRILSVGRDQILRASDTNKQT 1179
            .....:|...:.:|||    :|.....|..:     |.::.....|.:||....:||.
Mouse   984 PLVTSVNRRKEDELSIGSAPLGKQQSYQASEYASSPIKTKTVTESRPVSVPVKAVLRV------- 1041

  Fly  1180 VLSQLSNEIYSNNYNEETKSDESDAISFQS-HWSDKTTCTFQMRMASASYTHCPRFLRDVNACIT 1243
                          :||.:|.|.....|.: .|:...:.|.|:               ||.:|..
Mouse  1042 --------------HEECRSPEDKMKEFIAILWNAVKSLTLQL---------------DVQSCCV 1077

  Fly  1244 YFK-------------------RSLREFATSI----------------GNKATDMAKEFVQQV-R 1272
            :..                   ||.....|||                |:|..:..:|....: |
Mouse  1078 FIPNDNLPSPSTIVSGDIPGTVRSWYHGQTSIPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPR 1142

  Fly  1273 AVEQIGPVYPQRNRQDNW--------LDIIISSPI---IILPISNTSTNVLIANL-------GK- 1318
            .:.:.|..:|       |        :..::...:   ::.|:..|||..:.:..       |:
Mouse  1143 PILEEGDAFP-------WTISLHHFSIYTLLGKQVTLSLVEPMGCTSTLAVTSQKLLPVGPDGRH 1200

  Fly  1319 --ISC------SNAVKCDSDEFNESYTIEIKNTYVYSLNIDEGEYS-FNVHPAKNKDAIP----- 1369
              :.|      |..:||.:.:....|.:....:.|:|.....|..| .:|:|......||
Mouse  1201 SFVVCLHVDLESLEIKCSNPQVQLIYELADTMSKVWSKIQKRGNLSPSSVYPETVAGPIPGSPVW 1265

  Fly  1370 --------------ILHDTAITLQ---LYAG----YSDDNDEDKQLNRFSIKGSMVEALKVSLNR 1413
                          ...|...|.:   :.||    :||....::..:  :|.||   :.:||| .
Mouse  1266 SSVGTAPPDTSTCSPSADIGTTTEGDSVQAGDDSPFSDSVTLEQTTS--NIGGS---SGRVSL-W 1324

  Fly  1414 KQYELLLESIRYATNFSNEVLNESDELDQNGDIEP-TANIDAESIISTTIQFSVPVFQIN----- 1472
            .|:.|...:::.   |:.::..:..|:....::|. :|:||.:.:. |.::..|..|.|:
Mouse  1325 MQWVLPKATVKL---FAPDLEKKGTEVCMVSELEDLSASIDVQDVY-TKVKCKVESFSIDHYQSR 1385

  Fly  1473 --------------LQ---------------NEYHNDLINLTFKNF---NVKH------------ 1493
                          ||               ::.|. .::||:...   ||:|
Mouse  1386 PGEGWQSGHFEGVFLQCKEKPVTTTKLLDGAHQQHG-FLSLTYTKAVTKNVRHKLTSRNERRSFY 1449

  Fly  1494 -ISKGFDKDVEVVLKSVLMEDLKSDLT--SPFRNMVTSVDLEQKIKKNEMTSSSCPDLPSYCNSL 1555
             :|:|........|..:|:.....|:.  .|..|.:.|| ...|:.|.:.........|...::|
Mouse  1450 KLSEGLMDGSPHFLHEILLSAQAFDIVVCFPLLNAIASV-FHTKLPKTQREKRKSSGQPMRTHTL 1513

  Fly  1556 KNRSSSVPSCFYNHMQVKVFGGDQKYTSSN--KNELGKKKESQTLVIYKSHTGRSAQN--GKLEQ 1616
            .:|  ::|..:.|...:::|....:.|.|.  .|: ..|:::..|.:........|.|  |:...
Mouse  1514 TSR--NLPLIYINTSVIRIFVPQTEETQSTVAVNQ-AAKEDTMVLKVGSIAMAPQADNPLGRSVL 1575

  Fly  1617 TSSIQFNCLNLAI-------CVERWYTIFDFFGLVSVDNVNEKYPEEMKLVEKHIDKVCSKLKVS 1674
            ...|....|||.|       ..:|.|.|    .|.|: |:.....:::| .||.........:..
Mouse  1576 RKDIYQKALNLGILRDPGSEIEDRQYQI----DLQSI-NIGTAQWDQLK-PEKGSGSGGVPTESE 1634

  Fly  1675 IRSFNFTLIRN-ESLLSRVNVSNAVFMILQDPYSKIVEGCLGSVSVNDLTKYGNIYKQKFLTSGT 1738
            ..|.|..|..| .|.:.|.....|:...:...:|..:.|. .::....:....|::.::.|..|.
Mouse  1635 RNSQNPALEWNMASSIQRHQERRAILTPILTDFSVRITGA-PAIIFTKIISQENLHMEEILVCGH 1698

  Fly  1739 EALNFVYKKKLVDLEALNTLDTDSTLRINMSAVHYIHTKRFSTELHVFVKDLLQLQTPVIRKLKK 1803
                        .||...|.:.|..|  :::.|..:|        .:.|.::..|: |..:..:.
Mouse  1699 ------------SLEVNITTNLDFFL--SVAQVQLLH--------QLIVANMTGLE-PSTKATEI 1740

  Fly  1804 HGSEQNMRPSKMKLVIQADSPVIVLPSSYNRNEVIIAYLGQFSLKNSFHFASDNNIISKMSATPS 1868
            ...||       |.|...|.......|.|:.                   |.|:.|.|
Mouse  1741 SKQEQ-------KKVDTFDGGTAETSSRYSG-------------------AQDSGIGS------- 1772

  Fly  1869 KDEILDVMRIDLVNINLFSGERSSMKAKADQEKDRIIIADMNFLRLGQPFFNESCFLHLQLERNL 1933
                 |.::|.:|.|..:||......|:...:..  |:.::||:    ||
Mouse  1773 -----DSVKIRIVQIEQYSGASQHRIARPSHQSS--IVKNLNFI----PF--------------- 1811

  Fly  1934 SADAHRVCPDISVQGTFSKLS----GIINIQQYKLI---------RSFLNNNIGEQTDDIYMNYH 1985
                     ||.:  |.|::|    ..:.:.::||.         |:||  |:.|...|:..  .
Mouse  1812 ---------DIFI--TASRISLMTYSSVALPKFKLPEQKEDGKTGRTFL--NLAEVDSDVAK--P 1861

  Fly  1986 NNSCTSI----ERLSTINLMPKNEVSKIVSI-------------LISIRILLE---------DVS 2024
            |.:|.|:    :.||:.......:..:::|:             .:.:.::.:         ::.
Mouse  1862 NQACVSMVTAEDPLSSSTSFSSGKKVRVLSLESLHASTRSSARQALGVTVVRQPGRRGTGDLELD 1926

  Fly  2025 LLLALNTSQSAAIEPLACIHFLKSTLEIDLFSDGSQDIDL--ISSNILIVDE-RNESDKSNENVF 2086
            |.|.|..||.:.:  |:| |..|..:|:.:|     |..|  :.|:....|. :...:.|:.|:.
Mouse  1927 LFLHLIVSQPSLL--LSC-HHRKQRVEVSIF-----DAMLKGVPSDYTCTDPGKTLPEASDYNIV 1983

  Fly  2087 -----------KNILEPSKKEVRIEN------SVQVEVHCRKKATFSKYTIMLNNMRVFALLSF- 2133
                       |:.:.||...:.|::      .:.::|....||.                |||
Mouse  1984 WLQTVPGETDSKSGIPPSLVTLHIKDFLNGPADIYLDVSKPLKAN----------------LSFT 2032

  Fly  2134 -LDQLKSYLQ------------------------EDSPAP-----------VVNNAANQIAQKPQ 2162
             |||:..:|:                        ::.|.|           |..:.|.:.:.:..
Mouse  2033 KLDQINHFLKKIKKAHSSAHSKETSTPSDSILNMDEPPVPKCYRGKLSKTKVHCDEAQKTSFQEN 2097

  Fly  2163 IDTSISTEYVVNITDSEIIFAEE--------C-----SRLDSNA--------------------- 2193
            |..:||....|::..::|:.:.|        |     |.|:.:.
Mouse  2098 IWRAISCFQKVSVHTTQIVVSMETVPHPHKPCVLASLSNLNGSLTVKAAQKVPGASLGSSFLLSI 2162

  Fly  2194 --IILKSTTVICYKPNSNIV--PLSLDINHLEIFSCTLDAEEESALSIIDPFTLIIELRSNCLNI 2254
              ::||::    .|..|.|:  |.|..:| ||...|..........||  | .:.::||...|.:
Mouse  2163 HDVLLKTS----LKERSRILIGPFSATVN-LEAKWCKHSGNPGPQQSI--P-KISMDLRGGLLQV 2219

  Fly  2255 LI-QKHLN-IRLSYVDVKLFS-------------RMARLLPTQTSRPKNVISKADSD-------- 2296
            .. |:||| :.|.:   :||:             ..|..:|:...:.:...::..||
Mouse  2220 FWGQEHLNCLALLH---ELFNGYLQEGKSEMPVPESAPQMPSPVEKTQAFKTEQSSDDLRTGIFQ 2281

  Fly  2297 -LEKAAPLVAMGFEISDCLYAMQINN------WRIND----AAIWLSQQKQNTYRNPALEMKTA- 2349
             ::.|..|...|  :.:.|:..:...      ||..:    ..:.::....||..:|  ::.||
Mouse  2282 YVQDAESLKLPG--VYEVLFYNETEESPGMMLWRYPEPRVLTLVRITPVPFNTTEDP--DISTAD 2342

  Fly  2350 ---------------------------------VVDASLISVFIIDDCMDADVPLLEVSLSKFLL 2381
                                             |.:..|..:.::.|    ...|:...|.:.:|
Mouse  2343 LGDVLQVPCGLEYWDELQKVFVAFQEFSLSESKVCELQLPDINLVHD----QKKLVSSDLWRIVL 2403

  Fly  2382 NFTFQTQDPNPKETNIRHYSLGN-IDTEVSVNYYNRRLSGWEPVAETW----------ESNLNWK 2435
            |....|.|.....:.....|... :.|..::....|..|.:.|    |          .::|.::
Mouse  2404 NNNQNTTDDQSSASESGSQSTCEPLVTPTALAACTRVDSCFTP----WFVPSLCMSFQFAHLEFR 2464

  Fly  2436 YTKGHLDNKKRFEIGISSKQMLK-----LNVTSTFIELFHMV---------LKNWTN-------- 2478
            ... |||     ::|.:|.|.|:     .||.|   ||.:|:         |:.|.:
Mouse  2465 LCH-HLD-----QLGTASPQYLQPFISDKNVPS---ELEYMIISFREPNLHLRQWNSGPVCQEIK 2520

  Fly  2479 -----DFNDNGAKNFRQRSPFIPFAL-----------QNLSGTPLLFKPIYAPLGDLTRSDLQQV 2527
                 |......:|...::...||.:           |.|..:.::...:....|......|...
Mouse  2521 FSSQMDCKLLECRNVTMQTVVKPFGICGQMALSSDGVQKLLDSTVIVDSVLVNFGQHVVHSLNTA 2585

  Fly  2528 -------------ELIKNWYSVQPNETKTFDFSQKSK-----LRHVHSHQLN---------LHQI 2565
                         ||:.:.:.:..:..:|..|.|...     |..:||||.:         ||
Mouse  2586 IQAWQQNKCPEVEELVFSHFVICNDTQETLRFGQVDTDENILLASLHSHQYSWRSHKSPQLLH-- 2648

  Fly  2566 FVQIHGWTLIG------PISVDKVGMFFRTTKLDSQFLTKSRIVFDISLIGSAQKLIKVKSSLGV 2624
             :.|.||   |      |.:||..|.|.||.:...:   .:.::..:..:...||.|.:.....:
Mouse  2649 -ICIEGW---GNWRWSEPFTVDHAGTFIRTIQYKGR---TASLIIKVRALSGVQKQIIICGRQII 2706

  Fly  2625 INKLDRNVFLKMTLKGTHSDGLSSISVIKPN-DELSVPLKFIDASLYVAHNTSESDAYEDTGFSN 2688
            .:.|.:::.||:.   .|..|....:|::.: |.|:...|.   ..|:..|             |
Mouse  2707 CSYLSQSIELKVV---QHYIGQDGQAVVREHFDCLTAKQKL---PSYILEN-------------N 2752

  Fly  2689 E--EILWKACGKDD-TRQL-----LAGYDT-------NKSILYTFVNISREIYHCKEQNLPGHKI 2738
            |  |:..||.|.:| :|.:     .:.|.|       |.||:|.:..:                :
Mouse  2753 ELTELCVKAKGDEDWSRDVCLEPKASEYSTVIQVPTSNSSIIYVWCTV----------------L 2801

  Fly  2739 TLLPPLKINNMLCCDLMFKIHEHATGRINSSESVNIYNVNICQPLNLSITLDNFQLSGQLKIPVS 2803
            ||.|..::...:.                           :..||        |.:...|..|:
Mouse  2802 TLEPNSQVQQRMI---------------------------VFSPL--------FIMRSHLPDPI- 2830

  Fly  2804 HRGVIEPKLKLIDIQKRELHVRVSIQSVPGKGMELYISAPVWIINKTGLPLIYKQEGTSHTAAGQ 2868
                      :|.::||.|.:. ..|.:||:|.|              .||...:....|....|
Mouse  2831 ----------IIHLEKRSLGLS-ETQIIPGRGQE--------------NPLQNVEPDLVHHLTFQ 2870

  Fly  2869 F-EEHETARQVAPLMFSFSDQEGSPALVLR--------------LGKAYGSNN----MWCKSFST 2914
            . ||::.:....|:         |.||:.:              |.:.||...    .|..|
Mouse  2871 AREEYDPSDCAVPI---------STALIKQIATKIQPGGTVNEMLDEFYGPEKSQEPTWPYS--- 2923

  Fly  2915 HKDLADRDLRAENTKGSYAIGISVRRGRGLYACTTFVTLSPRFHLHNRSGYKLEFMQLCDIVNYD 2979
            :|| :||:.:.........:.:|:.:.   |..|..:.|.|...|.|:|.:.|...:...||.
Mouse  2924 NKD-SDRNEQLSQWDSPMRVKLSIWKP---YVRTLLIELLPWALLINQSKWDLWLFEGEKIVL-- 2982

  Fly  2980 RPDPRKIISAPVDCNF--AF----HWPNWDQEQIICVRIPEIECCCWSKGIPIKDVQSLYINVRN 3038
            :....|||..|   ||  ||    :|.|.:...               |.:.||.|.:|   ...
Mouse  2983 QVPAGKIIIPP---NFQEAFQIGIYWENTNTVH---------------KTLAIKLVHNL---TSP 3026

  Fly  3039 EW-----GEMFFLRLEIISKDATFILLFTDARTLPPPIR--------------IDNCSEVVINFS 3084
            :|     ||:..|..|          .|.||.     ||              |.:..:..|...
Mouse  3027 KWKDGGNGEVVTLDEE----------AFVDAE-----IRLGAFPGHQKLCQFCISSMVQHGIQVI 3076

  Fly  3085 QLRSKPVWI--TP----VRPQSSLS---------YVMDDPLGQQILLMEAPGGNMIEFPINNKNN 3134
            |:..|...|  ||    .:|..::|         :|.|     .......|||   |.|....::
Mouse  3077 QIEDKTTVINNTPYQIVYKPHLAISNSYSGKEHCHVPD-----SATFSICPGG---EHPAVRSSS 3133

  Fly  3135 IKKTLTYTNFIYIAFQGTFERSNEEENT---HRQLVLG---VRGKKVVIVEKNSGDRSQLWLMNS 3193
            :.           .:..|....:.|.:|   .:|::||   |.|          .|.:|.|.:.:
Mouse  3134 LP-----------CWDVTPAVGSSELDTATLQKQILLGFSPVPG----------ADSAQCWSLPA 3177

  Fly  3194 --NGQLEHEGSTPPIQTNDAN-----AVRLV---------LDLEKAPNPMEFTNLVVRTPNKQRV 3242
              .|:...:....|..|...|     |:.|.         :.|.:.|:|
Mouse  3178 IIGGEFPRQSVAVPFGTGRENGFCTRAIALTYQEHLGVTYITLSEDPSP---------------- 3226

  Fly  3243 TTQTWRFENGRLMCHANMCVQSRFGESGLK--PNYEAVVGRTENRASSSKQIPIGQHIVAQKLRP 3305
                      |::.| |.|......:..::  |.::                     :..:|:.|
Mouse  3227 ----------RVVFH-NRCPVPMLMKENIRDIPKFD---------------------VYCKKIPP 3259

  Fly  3306 GSGQLELSTKMDGPISTIEICDIKIKQNSVFLTPDLL------WMHASLNNRQITDKGKVSFVHE 3364
            .|   .:..::...|.:...|..|....|:||..|.:      |......|.|.|
Mouse  3260 ES---SVHHELYHQIISYPDCKTKDLLPSLFLRIDSMEEMTAEWSDPVDINSQGT---------- 3311

  Fly  3365 YLINVELVKGIG-ISIIARKPCEEIMFISLDHINCDIVQSALENSLDLNIAYIQIDNQLLDAVSP 3428
               .|..:.|.| :.:...:.|..:..|.........:.::...:|:..:.:.....||..|||.
Mouse  3312 ---QVVFLTGFGYVYVDIAQQCGTVFIILAPEGKAGPIFTSTSRALERMVTFRMFITQLSLAVSD 3373

  Fly  3429 IALHTQTSNDLEETQNAVVLKLKMLPS-------P-----------------------NKNAIIF 3463
            ...|...|..|..|.:.|.|.:..:|:       |                       ||:...|
Mouse  3374 DLTHQAPSELLRLTLDNVFLHVSPVPALLPGEEPPSSFFQLYGVEVYCGDLQLDNQLYNKSNFHF 3438

  Fly  3464 KYLTL--------------DLKPSTASLEE-------KLILKVASFLGYGKINRQNLSVQYQFEN 3507
            ..|..              .|..|:.:|||       ||.|.|:.    ||....::| ::.||.
Mouse  3439 AVLVCQGERTDPAQYSRVQSLLVSSKALEEYKENCFIKLCLTVSE----GKDILLDVS-EFTFEL 3498

  Fly  3508 TDDKPFLQDMKRYYFENL-SIGATQVRLSA-----FTSSK-LPVELHETKKALGLTLIKFEDALI 3565
            ...:.:::|...||.:.| .......|:|.     ||..: |||::.:..||| :..:|....||
Mouse  3499 KPARLYVEDTFVYYIKTLFDTYLPPSRMSGHHAQLFTGQQVLPVQVTQHAKAL-VNAVKLRKLLI 3562

  Fly  3566 E-----------LDRYSDKLH-------FETMDVYR------KELKKHYINQVKWHAAAILGSVD 3606
            :           |..|....|       ||...|:.      ..|..||.....:.|..::||::
Mouse  3563 QPVNLLISIHASLKLYIASDHTPLSFSVFERGPVFTTARQLVHALAMHYAAGALFRAGWVVGSLE 3627

  Fly  3607 FLGNPLGFANDLSEGVSG---LIFEGSVK--------------SLVKNVTHGISNSTAKLTETLS 3654
            .||:|......:..|:|.   |.:||..:              |.||:::.|...|...|..:|:
Mouse  3628 ILGSPASLVRSIGNGISDFFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKGALTSITNLATSLA 3692

  Fly  3655 DSLGKVVLD-DHDN---ETRQRILELQSNTSGGHLAAGLKGLGFGLLGGVTSIV-------RHTY 3708
            .::|::.|| :|.|   |.|:::.|    :.|..|..||..||..|||.:..||       :.|.
Mouse  3693 RNMGRLSLDEEHYNRQEEWRRQLPE----SLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTS 3753

  Fly  3709 DGATSDG--VPGFLSGLGKGLVGTVTKPIIGVLDLASETASAVRETSRDSHRNAPERKRLPRCVT 3771
            :...|.|  ..|.:||:|||::|..||||.|..:|.|:|...:                    :.
Mouse  3754 ETQASAGHKAKGVISGVGKGIMGVFTKPIGGAAELVSQTGYGI--------------------LH 3798

  Fly  3772 GAPGGLLPLYSNRQSKGQQYLYLINQKNFSEKIISYEPNLW----------------------SD 3814
            ||....||    :|.....:||.....|      |:...:|                      |.
Mouse  3799 GAGLSQLP----KQRCQPTHLYADQAPN------SHVKYVWKMLQSLGRPEVHMALDVVLVRGSG 3853

  Fly  3815 KEARLRLLVSTEYVRIFSLSDANPTIMFECHVSEILSC 3852
            :|....||:::|.:.:.|:|:......|.  ::|| ||
Mouse  3854 QEHEGCLLLTSEVLFVVSISEDTQQQAFP--ITEI-SC 3888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps13D	NP_729825.2	Chorein_N	4..112	CDD:315323	26/120 (22%)
		VPS13	147..368	CDD:318996	37/233 (16%)
		VPS13_mid_rpt	<656..837	CDD:318998	29/184 (16%)
		VPS13	<2039..>2694	CDD:330393	157/902 (17%)
		SHR-BD	2836..3113	CDD:310922	67/335 (20%)
		VPS13	<3346..3802	CDD:330393	129/568 (23%)
Vps13b	NP_796125.2	Chorein_N	3..102	CDD:315323	23/98 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..133		8/49 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1262..1303		4/40 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1616..1637		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1735..1770		9/60 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2048..2067		0/18 (0%)
		SHR-BD	<2605..>2685	CDD:310922	21/88 (24%)
		VPS13_C	3557..3703	CDD:318997	32/145 (22%)
		ATG_C	3705..3809	CDD:312735	37/131 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030