DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps13D and VPS13D

DIOPT Version :9

Sequence 1:	NP_729825.2	Gene:	Vps13D / 39448	FlyBaseID:	FBgn0052113	Length:	3919	Species:	Drosophila melanogaster
Sequence 2:	NP_056193.2	Gene:	VPS13D / 55187	HGNCID:	23595	Length:	4388	Species:	Homo sapiens

Alignment Length:	4531	Identity:	1333/4531 - (29%)
Similarity:	2149/4531 - (47%)	Gaps:	775/4531 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRDLITWVLNTYLGKYLENLNSAQLSVALLSGEVELENIPIRKDALRSFNLPVEVTAGSIRKIK 65
            ||..|:.||||||||||:.|||:.|||||||.|.|||||:|::||||:...||.||.||.|.|:.
Human     1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGFIGKVT 65

  Fly    66 LQIPVRQFRTSPWCISIEGLFCIICPKNLDNWDYEKEKLQDLEYKLAVLDTAEAGWRSEKGKQME 130
            ||||..:....||.|||..|..|..|:.:.:::.|||||.:.|.|.|:|...|..|::::.::.|
Human    66 LQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEKWKNDRQQKGE 130

  Fly   131 SYYFSSYNNWLKYGTNMATNIIDNIELKISDVHFRFEDIVDTGKSKICTGIKIGSLTAQSCDCDW 195
            ||       |.....::.|.|::||||||.|||.||||.|.........||.|.:::.|
Human   131 SY-------WYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVSMQ------ 182

  Fly   196 TNGSYKMNNNEMNYKLVELKELSVYWDLLHEDIKCQ---SYSNQEILEKMHSTCELRSHNFIIKP 257
             |...:.....|..|.:::.|.|:||     |:.|.   .....|:.|.|..:.|.|||:::::|
Human   183 -NAVNEPVQKLMRKKQLDVAEFSIYW-----DVDCTLLGDLPQMELQEAMARSMESRSHHYVLEP 241

  Fly   258 ICATARWKRDKCQQVIRTKDKPRVSCELLVPEVVIDISKVQRLQMLDKLSEIRQVKEVRQYRLKR 322
            :.|:|..||:..::.:|::..||:.|::.:..:.:.:|::|..|:::.|.|:.:.:...::|..:
Human   242 VFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQVKFRRWK 306

  Fly   323 PTCTVESNPIAWWKYATICHGFDFKKNEEK--WLMLKENLRYMLLYKSIILNPNEN--LSAADKE 383
            |...:..|...||.:|...:.::.::..::  |..:....|..:.|.....|..:.  ||..|||
Human   307 PKVAISKNCREWWYFALNANLYEIREQRKRCTWDFMLHRARDAVSYTDKYFNKLKGGLLSTDDKE 371

  Fly   384 FKAYIESDRKISDLTIMRRICFEKVFTKGFAFESQNEQ----------------GKNMLFH---W 429
            ....||.::...:|.|:|.:..::...:....||..|.                |..||.:   |
Human   372 EMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGAPEPGGGSGMLQYLQSW 436

  Fly   430 FPNWMGWYANSPSTPNNEQDESL------KHLEDDILVALENSLQNSSD-------LKSDAVFGH 481
            ||.|.|||..  .||.....|.|      :.:.::|| ..|.....::|       .|.|.||..
Human   437 FPGWGGWYGQ--QTPEGNVVEGLSAEQQEQWIPEEIL-GTEEFFDPTADASCMNTYTKRDHVFAK 498

  Fly   482 FSIKLLKGLVILQTEDKLNDGRNKS--MEMQFNNFSAYLQLSPQLTSYTVGISLQEVYLIDKTSS 544
            .:::|.:|.|.|..:::.....|:|  |:::|::.....:..|:..|..:.:.|..::|.|..:.
Human   499 LNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAESLPRRNSSLLSVRLGGLFLRDLATE 563

  Fly   545 DTMHNYLIKP----QTGNTATPNQLVKNAALQED---------ILFQLQYE-NCNHLRFQ--LNI 593
            .||...|:.|    :.|..:....|...:|.:.|         .:|::.|| |..|..|:  ||:
Human   564 GTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNV 628

  Fly   594 KSKGLDLIYNEDAIQWLLDFL----ADSNSFKYSP--RNRVAK-------------KTDFMKNWN 639
            .::.|::|||..||:.:.||.    ..::.|.|..  ..|||:             |.:..:..:
Human   629 STRPLNIIYNPQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIRQTLD 693

  Fly   640 EMFSGNEVNR-KIWMFEIEIFAPRIIFLENYKVSNSLMVLLDFGKLEMRKMEVKRVIPVIESAVT 703
            .:..|:.:.. |.|...::|.||::||.:::|..|.::|::|.|::.:...:........:.:.:
Human   694 RLLVGDFIEESKRWTVRLDISAPQVIFPDDFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSAS 758

  Fly   704 ENTSDDDETYLTPCSTPP------ASEKSGSESPTLLENPKTESFLNKNVQLEYVLHNKIYDKYL 762
            |.|...|:.|.||.:|||      :|..:|.::|..    ....|..:.:| .:::..|:|::|.
Human   759 EETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPF----SGVEFSEEQLQ-AHLMSTKMYERYS 818

  Fly   763 INFTNLQVLVCKYEERWQACLKTS-SNFHLIDKFNINLTLEQRNIFTVDPEYPSFMLFGTCPTIL 826
            ::|.:||::|.:.::.|:...... ...|:::|||::|.||:|.|:|.||:||..:|.|..|.:.
Human   819 LSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLK 883

  Fly   827 IHGNEELIN---NCCNIM-KPIIKASKEM--ENIY-----RGGNTIYASERIKNLAE-----DDR 875
            ||.||:.|:   ||..:: .|.:|.|...  |.|:     ||.    ..:.:.||.:     :..
Human   884 IHINEDKISALKNCFALLTTPEMKTSDTQIKEKIFPQEEQRGS----LQDSVMNLTQSIVLLEQH 944

  Fly   876 SRVVI--------EFVMDQLVIEMQSTERSIAELQIIGARAGLTKEPHETNISMSVHGLLLVDAI 932
            :|.|:        ||.::.:.:.::|..|.|:.|::.|..|...|.|::..:|::||||||||.:
Human   945 TREVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTM 1009

  Fly   933 QSFGPDFELLVASHRHVGMDSLSGSLKHSAIVSPTS-PGSPNFFDRATSPHMITKAVQNIKMGDR 996
            |::|.||:||:|||:::..|..:|||:.|...||.| |...:..|.||             :.||
Human  1010 QTYGADFDLLMASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGAT-------------LNDR 1061

  Fly   997 S-TEFCDD----EDSTALISVDIKIVPPNESNSMQLHTT----SITFNSLDIIANQDTIIEILNF 1052
            | |....|    ::..:||.::.:.| .:|..||.|.:|    |:..|:||||.|.:||:|::.|
Human  1062 SATSVSLDKILTKEQESLIKLEYQFV-SSECPSMNLDSTLQVISLQVNNLDIILNPETIVELIGF 1125

  Fly  1053 AKRTLLAQNIFPSESPE-SPKE-ATEAPVDVVDQVDHKS----HNEIFFDFFRLNILLLYTI--- 1108
            .:::      ||.|..: ||:. .|:......:|..::|    :.|:..:..|||:|||.|:
Human  1126 LQKS------FPKEKDDLSPQPLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLLLRTVGMA 1184

  Fly  1109 KRDKFNVGRKVGTVTLTEAKINASFQSDLSIIGSLGGIQVIDITSEAFCHPRILSVGRDQILRAS 1173
            .|:|:  |||:.|.::...|:|.|..|...:.||||.:|::|:|.:...:..::|:|       :
Human  1185 NREKY--GRKIATASIGGTKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQYVVSIG-------N 1240

  Fly  1174 DTNKQTVLSQLSNEIYSNNYNEETKSDESDAISFQSHWSDKTTCTFQMRMASASYTHCPRFLRDV 1238
            ....:.::|.:.  .:.:.:.....:..::|:||......|..|...::|||..|.|..:||:::
Human  1241 SVGYENIISDIG--YFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKEL 1303

  Fly  1239 NACITYFKRSLREFATSIGNKATDM----AKEFVQQVRAVEQIGPVYPQRNR-----QDN----- 1289
            ...:...:.:.|....|...|.|.:    ..|:.:.|...|.     |::.|     ::|
Human  1304 TLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFET-----PRKTREPFILEENEIYGF 1363

  Fly  1290 ------------WLDIIISSPIIILPISNTSTNVLIANLGKISCSNAVKCDSDEFNESYTIEIKN 1342
                        .|:|.|.||::.:|....|..:|:.:||:|...|.|..|.:..::...:|||:
Human  1364 DLASSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRSDRLQVEIKD 1428

  Fly  1343 TYVYSLNI----------DEGEYSF-------------NVHPAKNK--------DAIPILHDTAI 1376
            ..:||||.          .||...|             ..|..::.        .|..||::|.|
Human  1429 IKLYSLNCTQLAGREAVGSEGSRMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTI 1493

  Fly  1377 TLQL---------YAGYSDDNDEDKQLNRFSIKGSMVEALKVSLNRKQYELLLESI--------- 1423
            ..:|         ...:|...|:....:...|:|..|..::|.|.:..||.:|:::
Human  1494 QFKLEKIPIERESELTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLDNLVYSEDL 1558

  Fly  1424 -RYATNFSNEVLNESD------------ELDQNGDIEPTANIDAESIISTTIQFSVPVFQI---- 1471
             :|..:.::....:|.            |..:||       :.:.|.:|.|.|.|:.|.::
Human  1559 NKYPASATSSPCPDSPLPPLSTCGESSVERKENG-------LFSHSSLSNTSQKSLSVKEVKSFT 1616

  Fly  1472 ---------NLQNEYHND-------LINLTFKNFNVKHISKGFDKD------VEVVLKSVLMED- 1513
                     .||.:...|       |::|.|::|.|:     |.||      :::.|.|:||||
Human  1617 QIQATFCISELQVQLSGDLTLGAQGLVSLKFQDFEVE-----FSKDHPQTLSIQIALHSLLMEDL 1676

  Fly  1514 LKSDLTSPFRNMVTS--VDLEQKIKKNEMTSSSCP-----DLPSYCNSLKNRSSSVPSCFYNHMQ 1571
            |:.:..|.::|::.|  ......:.:.|..|.|||     :.|....||.:.....|:.|..:
Human  1677 LEKNPDSKYKNLMVSRGAPKPSSLAQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLY-- 1739

  Fly  1572 VKVFGGDQKYTSSNKNE-------------------------LGKKKESQTLV------IYKSHT 1605
                   |:.||:::.:                         :||.|...:||      :.|.|.
Human  1740 -------QRPTSASRKKQKEVQDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLVDKKHP 1797

  Fly  1606 GRSAQNGKLEQTSSIQFNCLNLAICVERWYTIFDFFGLVS-VDNVNEKYPEE-----MKLVEKHI 1664
            ..|:...::.::..:.||||::.|.::.|..|.||||:.| .||...:.|.|     :|| |.|.
Human  1798 EFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHAMRLPPEGILHNVKL-EPHA 1861

  Fly  1665 -------DKVCSKLKVSIRSFNFTLIRNESLLSRVNVSNAVFMILQDPYSKIVEGCLGSVSVNDL 1722
                   |.|.:||.:.:.|.:..|.:..|.|::.|||..|..:........::|.:||:|::||
Human  1862 SMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGSLSLSDL 1926

  Fly  1723 TKYGNIYKQKFLTSGTEAL---NFVYKKKLVDLEALNTLDTDSTLRINMSAVHYIHTKRFSTELH 1784
            |.:|..|:::|.|||.|||   .|.|.:.    :.|...:.|..:.:.|::|.|:||:||..|:.
Human  1927 TCHGEFYRERFTTSGEEALIFQTFKYGRP----DPLLRREHDIRVSLRMASVQYVHTQRFQAEVV 1987

  Fly  1785 VFVKDLLQLQTPVIR-KLKKHGS---EQNMRPSKMKLVIQADSPVIVLPSSYNRNEVIIAYLGQF 1845
            .|::...|||..:.| :....|.   :|..|.|::.|.|:|.:||:::|.|...|.:|:|.||:.
Human  1988 AFIQHFTQLQDVLGRQRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKL 2052

  Fly  1846 SLKNSFHFASDNNIISKM------SATPS------------------------------------ 1868
            .:||.|.||......|..      ||:|:
Human  2053 KVKNKFLFAGFPGTFSLQDKESVPSASPTGIPKHSLRKTTSTEEPRGTHSQGQFTMPLAGMSLGS 2117

  Fly  1869 -KDE------------------------------ILDVMRIDLVNINLFSGERSSMK-AKADQEK 1901
             |.|                              :||.:.:||.::::|:.||...: :||.::.
Human  2118 LKSEFVPSTSTKQQGPQPTLSVGQESSSPEDHVCLLDCVVVDLQDMDIFAAERHPREYSKAPEDS 2182

  Fly  1902 DRIIIADMNFLR-LGQPFFNESCFLHLQLERNLSADAHRVCPDISVQGTFSKLSGIINIQQYKLI 1965
            ...:|....|:| .|.....|.|.|.||:||||..:.....||||:.|..|.:...:::.:||||
Human  2183 SGDLIFPSYFVRQTGGSLLTEPCRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLI 2247

  Fly  1966 RSFLNNNIGEQTDDIYMNYHNNSCTSIERLSTINLMPKNEVSKIVSILISIRILLEDVSLLLALN 2030
            |..|.||:||..::....|....    .|:.|:   ...||...:..||.    :.:|||.|. :
Human  2248 RGLLENNLGEPIEEFMRPYDLQD----PRIHTV---LSGEVYTCMCFLID----MVNVSLELK-D 2300

  Fly  2031 TSQSAAIEPLACIHFLKSTLEIDLFSDGSQDIDLISSNILIVDERNESDKSN---ENVFKNILEP 2092
            ..:......||...|.|..|..:.||:.::.|:|:|.:::..|.|....|::   .|||..|.:|
Human  2301 PKRKEGAGSLARFDFKKCKLLYESFSNQTKSINLVSHSMMAFDTRYAGQKTSPGMTNVFSCIFQP 2365

  Fly  2093 SKKEVRIENSVQVEVHCRKKATFSKYTIMLNNMRVFALLSFLDQLKSYLQEDSPAPVVN------ 2151
            :|.....:.|:|:|:|.|.....|.:|::|||:|||.:..:|..:..:|...|.....|
Human  2366 AKNSSTTQGSIQIELHFRSTKDSSCFTVVLNNLRVFLIFDWLLLVHDFLHTPSDIKKQNHVTPSR 2430

  Fly  2152 --NAANQIAQKPQ-IDTSIST-------------EYVVNITDSEIIFAEECSRLDSNAIILKSTT 2200
              |::::.|..|: :.:.:.|             |..||:|.:|.:..|:.|..|:||||||.||
Human  2431 HRNSSSESAIVPKTVKSGVVTKRSSLPVSNERHLEVKVNVTGTEFVVIEDVSCFDTNAIILKGTT 2495

  Fly  2201 VICYKPNSNIVPLSLDINHLEIFSCTLDAEEESALSIIDPFTLIIELRSN--------------- 2250
            |:.|||.....|.|..:..:|:|||.|..|.::||||:||..:.:||..|
Human  2496 VLTYKPRFVDRPFSGSLFGIEVFSCRLGNEHDTALSIVDPVQIQMELVGNSSYQNSSGLMDAFNS 2560

  Fly  2251 -----CLNILIQKHLNIRLSYVDVKLFSRMARLLPTQTSR--PKNVISKADS------------- 2295
                 .|.|.:|. |:|||||.||:||..:|:.:|.|.:.  |.:|..::||
Human  2561 EDFPPVLEIQLQA-LDIRLSYNDVQLFLAIAKSIPEQANAAVPDSVALESDSVGTYLPGASRVGE 2624

  Fly  2296 ------------DLE-KAAPLVAMGFEISDCLYAMQINNWRINDAAIWLSQQKQ--------NTY 2339
                        .|| :.|.|..:||.:.||..|:.....::..||.||.:..:        :|.
Human  2625 EIREGTRHTLDPVLELQLARLQELGFSMDDCRKALLACQGQLKKAASWLFKNAEPLKSLSLASTS 2689

  Fly  2340 RNP----ALEMKTAV-VDASLISVFIIDDCMDADVPLLEVSLSKFLLNFTFQTQDPNPKETNIRH 2399
            |:.    |..:.:.| :.|..:.:..||||||.||||.|::.|:  ||| .|....:|:  ...|
Human  2690 RDSPGAVAAPLISGVEIKAESVCICFIDDCMDCDVPLAELTFSR--LNF-LQRVRTSPE--GYAH 2749

  Fly  2400 YSLGNIDTEVSVNYYNRRLSGWEPVAETWESNLNWKYTKGHLDNKKRFEIGISSKQMLKLNVTST 2464
            ::|       |.:||||.||||||..|.|..:::|:.......:..|.::...:|..|.:|:||.
Human  2750 FTL-------SGDYYNRALSGWEPFIEPWPCSVSWQQQAASRLHPPRLKLEAKAKPRLDINITSV 2807

  Fly  2465 FIELFHMVLKNWTNDF--NDNG------------------------------------------- 2484
            .|:.:....::|..|:  :|..
Human  2808 LIDQYVSTKESWMADYCKDDKDIESAKSEDWMGSSVDPPCFGQSLPLVYLRTRSTASLTNLEHQI 2872

  Fly  2485 -----AKNFRQRSPFIPFALQNLSGTPLLF----------------KPIYAPLGDLTRSDLQQVE 2528
                 .|..::|.||:||||:|.:|..|.|                .|...|.|:.|  .|....
Human  2873 YARAEVKTPKRRQPFVPFALRNHTGCTLWFATLTTTPTRAALSHSGSPGVVPEGNGT--FLDDTH 2935

  Fly  2529 LIKNWYSVQPNETKTFDFSQKSKLRHVHSHQLNLHQIFVQIHGWTLIGPISVDKVGMFFRTTKLD 2593
            .:..|..|...|...|:|..:.||||.|:|.|.:||:.|:::||..:.|:||||||.|||....|
Human  2936 NVSEWREVLTGEEIPFEFEARGKLRHRHTHDLRIHQLQVRVNGWEQVSPVSVDKVGTFFRYAAPD 3000

  Fly  2594 S-----------------------QFLTKSRIVFDISLIGSAQKLIKVKSSLGVINKLDRNVFLK 2635
            .                       ..|...|:||.:::.|||:|:|.|:|:|.|.|:|:..:.|:
Human  3001 KNSSSSTIGSPSSRTNIIHPQVYFSSLPPVRVVFAVTMEGSARKVITVRSALIVRNRLETPMELR 3065

  Fly  2636 MTLKGTHSDGLSS------ISVIKPNDELSVPLKFIDASLYVAHNTSESDAYEDTG----FSNEE 2690
            :       |..|:      :..|.|.|..:|||          |.||........|    |....
Human  3066 L-------DSPSAPDKPVVLPAIMPGDSFAVPL----------HLTSWRLQARPKGLGVFFCKAP 3113

  Fly  2691 ILW----KACGKDDTRQLLAGYDTNKSILYTF-VNISREIY-HCKEQNL-----------PGHKI 2738
            |.|    |......:::.....||.||..:.| |.|.:|.| .....|:           |||.|
Human  3114 IHWTNVVKTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPDYMPSNIFSDSAKQIFRQPGHTI 3178

  Fly  2739 TLLPPLKINNMLCCDLMFKIH-EHATGRINSSESVNIYNVNICQPLNLSITLDNFQLSGQLKIPV 2802
            .|||.:.|.|:|.|:|.|.:. ....|.:...:...::..:..|.:.|.::|:||.|..:|.||.
Human  3179 YLLPTVVICNLLPCELDFYVKGMPINGTLKPGKEAALHTADTSQNIELGVSLENFPLCKELLIPP 3243

  Fly  2803 SHRGVIEPKLKLIDIQKRELHVRVSIQSVPGKGMELYISAPVWIINKTGLPLIYKQEGTSHTAAG 2867
            ..:..: .:::|.|:.:|:|::.:.|.......::::||||.|:|||||||||::|:.....|||
Human  3244 GTQNYM-VRMRLYDVNRRQLNLTIRIVCRAEGSLKIFISAPYWLINKTGLPLIFRQDNAKTDAAG 3307

  Fly  2868 QFEEHETARQVAPLMFSFSDQEGSPALVLRLGKAYGSNNM--WCKSFSTHKDLADRDLRA---EN 2927
            ||||||.||.::||:|.::|:|......:|:|:......|  ||:.||.......|.|:.   .|
Human  3308 QFEEHELARSLSPLLFCYADKEQPNLCTMRIGRGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGN 3372

  Fly  2928 TKG-SYAIGISVRRGRGLYACTTFVTLSPRFHLHNRSGYKLEFMQLCDIVNYDRPDPRKIISAPV 2991
            ..| .|.|||.|::|||.|..|..|..:||:.|.|:|.:||.|.|..........:|...||...
Human  3373 RPGLIYNIGIDVKKGRGRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLP 3437

  Fly  2992 DCNFAFHWPNWDQEQIICVRIPEIECCCWSKGIPIKDVQSLYINVRNEWGEMFFLRLEIISKDAT 3056
            ..:..||||..|.:|::|||:.::..|.||.|..:....|.:||:|:..|:.||||:||..:.||
Human  3438 GSSVVFHWPRNDYDQLLCVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGAT 3502

  Fly  3057 FILLFTDARTLPPPIRIDNCSEVVINFSQLR-SKPVWITPVRPQSSLSYVMDDPLGQQILLMEAP 3120
            :.:.|:|...||||.||||.|:|.:.|:|.. ::|...|.|:|.:||.|..|:|.....:.:...
Human  3503 YRISFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLRTEVKPMTSLDYAWDEPTLPPFITLTVK 3567

  Fly  3121 GGNMIEFPIN-NKNNIKKTLTYTNFIYIAFQGTFERSNEEENTHR-----------QLVLGVRGK 3173
            |....|...| |.....:.|.|.||||||...||  |..:|.|.|           :|||.|..|
Human  3568 GAGSSEINCNMNDFQDNRQLYYENFIYIAATYTF--SGLQEGTGRPVASNKAITCAELVLDVSPK 3630

  Fly  3174 --KVVIVEKNSGDRSQLWLMNSNGQLEHEGSTPPIQTNDANAVR-----LVLDLE--KAPNPMEF 3229
              :|::.:|..|.|||||.|...|.|.||||:.|...|..:|.|     .:||:.  .|.....:
Human  3631 TQRVILKKKEPGKRSQLWRMTGTGMLAHEGSSVPHNPNKPSAARSTEGSAILDIAGLAAVTDNRY 3695

  Fly  3230 TNLVVRTPNKQRVTTQTWRFENGRLMCHAN-MCVQSRFGESGLKPNYEAVVGRTENRASSSKQIP 3293
            ..|::|.|:::|.|||||.|..|:|.|..: :.||::.|.|||....|.|:| .:........:|
Human  3696 EPLMLRKPDRRRSTTQTWSFREGKLTCGLHGLVVQAKGGLSGLFDGAEVVLG-PDTSMELLGPVP 3759

  Fly  3294 IGQHIVAQKLRPGSGQLELSTKMDGPISTIEICDIKIKQNSVFLTPDLLWMHASLNNRQITDKGK 3358
            ..|..:.||:|||||.|.:....|||...::|.|...:::|.....|.|    .:..:::.....
Human  3760 PEQQFINQKMRPGSGMLSIRVIPDGPTRALQITDFCHRKSSRSYEVDEL----PVTEQELQKLKN 3820

  Fly  3359 VSFVHEYLINVELVKGIGISIIARKPCEEIMFISLDHINCDIVQSALENSLDLNIAYIQIDNQLL 3423
            .....|..:.|.|..|||:|:|.:.| ||::|.||..||....|.|..:.|:|:|..:|:||||:
Human  3821 PDTEQELEVLVRLEGGIGLSLINKVP-EELVFASLTGINVHYTQLATSHMLELSIQDVQVDNQLI 3884

  Fly  3424 DAVSPIALH-TQTSNDLEETQNAVVLKLKMLPSPNKNAI--IFKYLTLDLKPSTASLEEKLILKV 3485
            ....|..|: |..||:.|..:....:::..:..|:|:|:  |:|:|.:..:..|..:||||:||:
Human  3885 GTTQPFMLYVTPLSNENEVIETGPAVQVNAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKL 3949

  Fly  3486 ASFLGYGKINRQNLSVQYQFENTDDKPFLQDMK--RYYFENLSIGATQVRLSAFTSSKLPVELHE 3548
            .||.||.:...:   |:...||..:|...|...  |||||||.|...|::||.|||:|||::|..
Human  3950 LSFFGYDQAESE---VEKYDENLHEKTAEQGGTPIRYYFENLKISIPQIKLSVFTSNKLPLDLKA 4011

  Fly  3549 TKKALGLTLIKFEDALIELDRYSDKLHFETMDVYRKELKKHYINQVKWHAAAILGSVDFLGNPLG 3613
            .|..||..||:||||:|.||.::....:||.:....::.||:..::...||.|||||||||||:|
Human  4012 LKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFLGNPMG 4076

  Fly  3614 FANDLSEGVSGLIFEGSVKSLVKNVTHGISNSTAKLTETLSDSLGKVVLDDHDNETRQRILELQS 3678
            ..||:||||:|||..|:|..|::|||||:|||.||...||||.|||.:  |:.:::.:..:...:
Human  4077 LLNDVSEGVTGLIKYGNVGGLIRNVTHGVSNSAAKFAGTLSDGLGKTM--DNRHQSEREYIRYHA 4139

  Fly  3679 NTSGGHLAAGLKGLGFGLLGGVTSIVRHTYDGA-TSDGVPGFLSGLGKGLVGTVTKPIIGVLDLA 3742
            .|||.||.||:.||..|::||:||::..|.:|. |..||.||:||||||||||||||:.|.||.|
Human  4140 ATSGEHLVAGIHGLAHGIIGGLTSVITSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGALDFA 4204

  Fly  3743 SETASAVRETSR-DSHRNAPERKRLPRCVTGAPGGLLPLYSNRQSKGQQYLYLINQKNFSEKIIS 3806
            ||||.|||:|:. ...|...:|.|.|||.|| |.||||.||..|::||:.|:.:......|..|:
Human  4205 SETAQAVRDTATLSGPRTQAQRVRKPRCCTG-PQGLLPRYSESQAEGQEQLFKLTDNIQDEFFIA 4268

  Fly  3807 YEPNLWSDKEARLRLLVSTEYVRIFSLSD--ANPTIMFECHVSEILSCHPVVTNAGTTPTTSSRA 3869
            .| |:.|     ..:|:|::.|......|  ....|..|....::..| .|..:.|......::.
Human  4269 VE-NIDS-----YCVLISSKAVYFLKSGDYVDREAIFLEVKYDDLYHC-LVSKDHGKVYVQVTKK 4326

  Fly  3870 SASHYIEISTNLPKITRPRIRCRSEECAEAASRCINYAKSVFDERE 3915
            :.|....:|...|...:|.:..:||..|...|:.||||||::.|::
Human  4327 AVSTSSGVSIPGPSHQKPMVHVKSEVLAVKLSQEINYAKSLYYEQQ 4372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps13D	NP_729825.2	Chorein_N	4..112	CDD:315323	59/107 (55%)
		VPS13	147..368	CDD:318996	59/225 (26%)
		VPS13_mid_rpt	<656..837	CDD:318998	54/190 (28%)
		VPS13	<2039..>2694	CDD:330393	234/843 (28%)
		SHR-BD	2836..3113	CDD:310922	114/283 (40%)
		VPS13	<3346..3802	CDD:330393	198/462 (43%)
VPS13D	NP_056193.2	Chorein_N	3..112	CDD:289396	59/108 (55%)
		VPS13	139..356	CDD:293513	59/228 (26%)
		VPS13_mid_rpt	614..894	CDD:293515	77/284 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..796		12/54 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1563..1582		1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1741..1771		2/29 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2070..2108		3/37 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2122..2145		0/22 (0%)
		UBA_VP13D	2642..2677	CDD:270491	11/34 (32%)
		SHR-BD	3276..3559	CDD:284143	114/282 (40%)
		VPS13_C	3984..4129	CDD:293514	76/146 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149786
Domainoid	1	1.000	497	1.000	Domainoid score	I356
eggNOG	1	0.900	-	-		E1_KOG1796
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15583
Inparanoid	1	1.050	1668	1.000	Inparanoid score	I78
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50136
OrthoDB	1	1.010	-	-		D10953at33208
OrthoFinder	1	1.000	-	-		FOG0006123
OrthoInspector	1	1.000	-	-		oto89935
orthoMCL	1	0.900	-	-		OOG6_106938
Panther	1	1.100	-	-	LDO	PTHR16166
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	1	1.000	-	-		X4414
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840