DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps13D and VPS13C

DIOPT Version :9

Sequence 1:	NP_729825.2	Gene:	Vps13D / 39448	FlyBaseID:	FBgn0052113	Length:	3919	Species:	Drosophila melanogaster
Sequence 2:	NP_065872.1	Gene:	VPS13C / 54832	HGNCID:	23594	Length:	3753	Species:	Homo sapiens

Alignment Length:	4258	Identity:	832/4258 - (19%)
Similarity:	1565/4258 - (36%)	Gaps:	1105/4258 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRDLITWVLNTYLGKYLENLNSAQLSVALLSGEVELENIPIRKDALRSFNLPVEVTAGSIRKIK 65
            :|..::..:||.:||.|:||||.:||.:.:..|.|.|:|:.|:::||...::|.:|.||.|.|:.
Human     2 VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLT 66

  Fly    66 LQIPVRQFRTSPWCISIEGLFCIICPKNLDNWDYEKEK--LQDLEYK------LAVLDTAEAGWR 122
            |:||.:.........::|||:.::.|.....:|..||:  |||::.|      .|:...||.|..
Human    67 LKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEEALQKAAEKGTH 131

  Fly   123 S------------------EKGKQMESYYFSSYNNWLK------------YGTNMATNIIDNIEL 157
            |                  .|.|:.:.::...:....:            :...:||.:|.|:::
Human   132 SGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKDTFVEKLATQVIKNVQV 196

  Fly   158 KISDVHFRFEDIVDTGKSKICTGIKIGSLTAQSCDCDWTNGSYKMNN-NEMNYKLVELKELSVYW 221
            ||:|:|.::||.|...|..:..|:.:|.|:..:.:..||  ...:|. :::.|||:.|..||.||
Human   197 KITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWT--PCILNEADKIIYKLIRLDSLSAYW 259

  Fly   222 DLLHEDIKC-QSY--SNQEILEKMHSTCELRSHN------FIIKPICATAR-WKRDKCQQVIRTK 276
                 ::.| .||  |.::||:::.:.. |.|.|      :|.:||.|:|: :.....:..::|
Human   260 -----NVNCSMSYQRSREQILDQLKNEI-LTSGNIPPNYQYIFQPISASAKLYMNPYAESELKT- 317

  Fly   277 DKPRVSCELLVPEVVIDISKVQRLQMLDKLSEIRQVKEVRQYRLKRPTCTVESNPIAWWKYA--- 338
              |::.|.:.:..:.|:::|.|.|.|:|.|..:..:.....||..:|...:.:|...|||||
Human   318 --PKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDS 380

  Fly   339 ----------TICHGFDFKKNEEKWLMLKENLRYMLLYKSIILNPNENLSAADKEFKAYIESDRK 393
                      .:....:.||:.:   :||.   |.:.||:.:..     |...:|.:..|:...|
Human   381 VLEVHIRRYTQMWSWSNIKKHRQ---LLKS---YKIAYKNKLTQ-----SKVSEEIQKEIQDLEK 434

  Fly   394 ISD---LTIMRRICFEKVFTKGFAFESQNEQGKNMLFHWFPNWMGWYANSPSTPNNEQ------- 448
            ..|   :.:.|:....:|...|.....::.........||   .|.:....|...:|:
Human   435 TLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWF---SGLWGKKESKKKDEESLIPETI 496

  Fly   449 DESLKHLEDDIL---VALENSLQNSSDLKSDAVFGHFSIKLLKGLVILQTEDKLNDGRN--KSME 508
            |:.:...|.|.|   :....|..|.: |....|....::||      :.|...:.:.:|  :.::
Human   497 DDLMTPEEKDKLFTAIGYSESTHNLT-LPKQYVAHIMTLKL------VSTSVTIRENKNIPEILK 554

  Fly   509 MQFNNFSAYLQLSPQLTSYTVGISLQEVYLIDKTSSDTMHNYLIKPQTGNTATPNQLVKNAALQE 573
            :|.......:...|...:..|...|:..|:......|.:.:  :....|:|.  :.|:|
Human   555 IQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPS--LVASIGDTT--SSLLK------ 609

  Fly   574 DILFQLQYENCNHLRFQLN-----------IKSKGLDLIYNEDAIQWLLDFLADSNSFKYSP-RN 626
                         ::|:.|           ::|:.:::||:...:..:::|...:....... .:
Human   610 -------------IKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQITS 661

  Fly   627 RVAKKTDFMKNWNEMFSGNEV-NRKIWMFEIEIFAPRIIFLE-NYKVSNSLMVLLDFGKLEMRKM 689
            ....|.:.:|........:.: .||:....|.:....::..: .:....|.:::||||..::.
Human   662 ATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGTFQLN-- 724

  Fly   690 EVKRVIPVIESAVTENTSDDDETYLTPCSTPPASEKSGSESPTLLENPKTESFLNKNVQLEYVLH 754
                                             |:..|.:..|             |..||.::
Human   725 ---------------------------------SKDQGLQKTT-------------NSSLEEIM- 742

  Fly   755 NKIYDKYLINFTNLQVLVCKYEERWQAC-LKTSSNFHLIDKFNINLTLEQRNIFTVDPEYPSFML 818
            :|.|||:.:...|:|:|..:.||.|:.| .:..|..|::...:|::.|.:..: ..|.....|.:
Human   743 DKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMARFKV 806

  Fly   819 FGTCPTILIHGNEELINNCCNIMKPIIKASKEMEN----------IYRGG-----------NTIY 862
            .|..|.:.:..:::.:.:...:|..|....|....          |..||           :|:.
Human   807 SGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSAQSPERQVSSIPIISGGTKGLLGTSLLLDTVE 871

  Fly   863 A---------------------SERIKNLAE---DDRSRVVIEFVMDQLVIEMQSTERSIAELQI 903
            :                     ...:|..||   ::...::::|.:.::::|
Human   872 SESDDEYFDAEDGEPQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVILE------------- 923

  Fly   904 IGARAGLTKEPHETNISMSVHGLLLVDAIQSFGPD-----FELLVASH-RHVGMD--SLSGSLKH 960
                  .||:..|.:       .:||..:...|.:     |:|.|.|: :.:.:|  .:.||.:.
Human   924 ------FTKQQKEED-------TILVFNVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRK 975

  Fly   961 --SAIVSPTSPGSPNFFDRATSPHMITKAVQNIKMGDRSTEFCDDEDSTALISVDIKIVPPNESN 1023
              ..|.|...||            :....|:.||.......|     .||....:
Human   976 PLHLISSSDKPG------------LDLLKVEYIKADKNGPSF-----QTAFGKTE---------- 1013

  Fly  1024 SMQLHTTSITFNSLDIIANQDTIIEILNFAKRTLLAQNIFPSE------------SPESPKEATE 1076
                .|..:.|:||:::.....::..:|:      ...|.||:            |.|..::.:.
Human  1014 ----QTVKVAFSSLNLLLQTQALVASINY------LTTIIPSDDQSISVAKEVQISTEKQQKNST 1068

  Fly  1077 APVDVVDQVDHKSHNEI--FFDFFRLNILLLYTIKRDKFNVGRKVGTVTLTEAKI-----NASFQ 1134
            .|..:|...|    ::|  |..|.:||...: .:..:|.|:         .|.||     :.|.|
Human  1069 LPKAIVSSRD----SDIIDFRLFAKLNAFCV-IVCNEKNNI---------AEIKIQGLDSSLSLQ 1119

  Fly  1135 S-DLSIIGSLGGIQVIDITSEAFCHPRILSVGRDQILRASDTNKQTVLSQLSNEIYSNNYNEETK 1198
            | ..|:...|..|.|.|:..:. .|.:.:|:                   :.||::..|.:....
Human  1120 SRKQSLFARLENIIVTDVDPKT-VHKKAVSI-------------------MGNEVFRFNLDLYPD 1164

  Fly  1199 SDESDAISFQSHWSDKTTCTFQMRMASASYTHCPRFLRDVNACITYF---KRSLREFATSIGNKA 1260
            :.|.|..:..|    |......:.:......:..:||..:...:..|   |.||.........:|
Human  1165 ATEGDLYTDMS----KVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERA 1225

  Fly  1261 TDMAKEFVQQVRAVEQIGPVYPQRNRQDNWLDIIISSPIIILPISNTSTNVLIANLGKISCSN-- 1323
            ....|:..|:...|.               ::|.:.:|:|::|.|:.|||.::.:||.|...|
Human  1226 ATSVKDLAQRSFRVS---------------INIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQF 1275

  Fly  1324 AVKCDSDEFN----ESYTIEIKNTYVYSLNIDEGEYSFNVHPAKNKDAIPILHDTAITLQLYAGY 1384
            ::..|.|..|    :...:::....:|...|..|.|    ||     .|.:||  .|.|:.....
Human  1276 SLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIY----HP-----DIQLLH--PINLEFLVNR 1329

  Fly  1385 SDDNDEDKQLNRFSIKGSMVEALKVSLNRKQ----YELLLESIRYATNFSNEV---LNESDELDQ 1442
            :.......::....|||.: :::.||||::.    :.:|.|::...|...::|   :.|:.|:.:
Human  1330 NLAASWYHKVPVVEIKGHL-DSMNVSLNQEDLNLLFRILTENLCEGTEDLDKVKPRVQETGEIKE 1393

  Fly  1443 NGDIEPTANI-DAESIISTTIQFSVPVFQINLQNEYHNDLINLTFKNFNVKHISKGFDKDVEVVL 1506
            ..:|..:.:: |:::.::|.::....|           |:||:.. ||.:|          |||:
Human  1394 PLEISISQDVHDSKNTLTTGVEEIRSV-----------DIINMLL-NFEIK----------EVVV 1436

  Fly  1507 KSVLMEDLKSDLTSPFRNM-VTSVDLEQKIKKNEMTSSSCPDLPSYCNSLKNRSSSVPSCFYNHM 1570
            ..:...:.|.   .|...: |..:.:|.|:|..:||:.:         .||..|.   .||
Human  1437 TLMKKSEKKG---RPLHELNVLQLGMEAKVKTYDMTAKA---------YLKKISM---QCF---- 1482

  Fly  1571 QVKVFGGDQKYTSS--------NKNELGKKKESQTLVIYKSHTGRSAQ--NGKLEQTSSIQFNCL 1625
                     .:|.|        |.:.:..:...:.|:......|...:  :...:|...:.|..|
Human  1483 ---------DFTDSKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASL 1538

  Fly  1626 NLAICVERWYTIFDFFGLV---SVDNVNEKYPE-----------EMKLVEKHI---DKVCSKLKV 1673
            :|.:.:|...:..||....   |..:.:||..|           .:|.|..:|   |....|:..
Human  1539 DLVLHLEALLSFMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITA 1603

  Fly  1674 SIRSFNFTLIRNESLLSRVNVSNAVFMILQDPYSKIVEGCLGSVSVNDLTKYGNIYKQKFLTSGT 1738
            .:.:||..:...:..::.:.:......|...|....|...|..:.|.:: ...:|:|:.....|.
Human  1604 ELNAFNVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNV-DLQSIHKKAVSILGD 1667

  Fly  1739 EALNF---VYKKKLVDLEALNTLDTDSTLRINMSAVHYIHTKRFSTELHVFVKDLL----QLQTP 1796
            |...|   :|..........:....|..|...:..:..::..:|...|..|:.:..    .|.|.
Human  1668 EVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTA 1732

  Fly  1797 VIRKLKKHGSEQN---MRPSKMKLVIQADSPVIVLPSSYNRNEVIIAYLGQFSLKNSFHFASDNN 1858
            .::..::..|...   .:..::.:.|...:|||::|.|......:||.||...::|.|
Human  1733 TVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKF------- 1790

  Fly  1859 IISKMSATP----SKDEILDVMRIDLVNINLFSGERSSMKAKADQEKDRIIIADMNFLRLGQPFF 1919
                 |..|    |...::|.|.|:|..:.|   .|:.::|...| .|..|:..:|.|
Human  1791 -----SLVPMEHYSLPPVIDKMNIELTQLKL---SRTILQASLPQ-NDIEILKPVNML------- 1839

  Fly  1920 NESCFLHLQLERNLSADAHRVCPDISVQGTFSKLSGIINIQQYKLIRSFLNNNIGEQTDDIYMNY 1984
                   |.::|||:|..:...|.:.::|....:...::.....::...|..|:||.:.......
Human  1840 -------LSIQRNLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQ 1897

  Fly  1985 HNNSCTSIERLSTINLMP------------KNEVSKIVSILISIRILLEDVSLLLALNT------ 2031
            .......:.::. ::.:|            |..:::|||:.....  .|.:|::|..|.
Human  1898 SVQETVRVRKVD-VSSVPDHLKEQEDWTDSKLSMNQIVSLQFDFH--FESLSIILYNNDINQESG 1959

  Fly  2032 ----SQSAAIEPLACIHFLKSTLEIDLFSDGSQDIDLISSNILIVDERNESDKSNENVFKNILEP 2092
                :.|..:..|. :|.:.|:.:  :|.|||.::.:......:.|.|...:::...:.
Human  1960 VAFHNDSFQLGELR-LHLMASSGK--MFKDGSMNVSVKLKTCTLDDLREGIERATSRMI------ 2015

  Fly  2093 SKKEVRIENSVQVEVHCRKKATFSKYTIMLNNMRVFALLSFLDQLKSYLQEDSPAPVVNNAANQI 2157
            .:|..:..||..:::..::....|:...:|:.:.|.|.:.||..:..:..:..|     .:...:
Human  2016 DRKNDQDNNSSMIDISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVP-----QSPENV 2075

  Fly  2158 AQKPQI--------------DTSISTEYVVN--ITDSEIIFAEECSRLDSNAIILKSTTVICYKP 2206
            |::.||              |.|:.....:.  |||.|::|....::.|:.|:.......:....
Human  2076 AKETQILPRQTATGKVKIEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLST 2140

  Fly  2207 NSNIVPLSLDINHLEIFSCTLDAEE--ESALSIIDPFTLIIELRSNC--------LNILIQKHLN 2261
            :.....:...:..|::.:|....|:  ::..:::.|.:|.:|   .|        :||::::.:
Human  2141 SKLEQMMEASVRDLKVLACPFLREKRGKNITTVLQPCSLFME---KCTWASGKQNINIMVKEFI- 2201

  Fly  2262 IRLSYVDVK-LFSRMARLLPTQTSRPKNVISKADSDLEKAAPLVAMGFEISDCLYAMQINNW--- 2322
            |::|.:.:. :.:.||.|.|           |...|..|            |....|: |.|
Human  2202 IKISPIILNTVLTIMAALSP-----------KTKEDGSK------------DTSKEME-NLWGIK 2242

  Fly  2323 RINDAAIWLSQQKQNTYRNPALEMKTAV--------VDASLI---------SVFIIDDC--MDAD 2368
            .|||...|.            |.:.||.        ::.|||         |:.:..:|  ....
Human  2243 SINDYNTWF------------LGVDTATEITESFKGIEHSLIEENCGVVVESIQVTLECGLGHRT 2295

  Fly  2369 VPLLEVSLSKFLLNFTFQTQDPNPKETNIRHYS---LGNIDTEVSVNYYNRRLSGWEPVAETWES 2430
            |||| ::.|||              ..||::::   ....|..:.|:|||...:.|||:.|..|.
Human  2296 VPLL-LAESKF--------------SGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLIERVEG 2345

  Fly  2431 NLNWKYTKGHLDNKK------------------RFEIGISSKQMLKLNVTSTFIELFHMVLKNWT 2477
            ...|..   .||.||                  :..|.|||...:.:.::.:.:.:|:    |..
Human  2346 KRQWNL---RLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN----NLA 2403

  Fly  2478 NDFNDNGAKNF----RQRSPFIPFALQNLSGTPLLFKP--IYAPLGDLTRSDLQQVELIKN---- 2532
            ..|::..|..|    :.|:   ||.::|..|.|:..||  ....:|...:||:..|:..:|
Human  2404 KGFSEGTASTFDYSLKDRA---PFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQNLELE 2465

  Fly  2533 WYSVQPNETKTFDFSQKSKLRHVHSHQLNLHQIFVQIHGWTLIGPISVDKVGMFFRTTKLDSQFL 2597
            :.|:.|        |.:..|..:...:.:...:.:..||:|.:..|.|.:.|......:..:...
Human  2466 YASMVP--------SSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNASH 2522

  Fly  2598 TKSRIV-FDISLIGSAQKLIKVKSSLGVIN---------KLDRNVFLKMTLKGTHSDGLSSISVI 2652
            :.|.:| .|.:   ...|:|.::|.|.:.|         |..:||.|           |..|.:.
Human  2523 SDSVLVQIDAT---EGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKL-----------LERIGIA 2573

  Fly  2653 KPNDELSVPLK------FIDASLYVAHNTSESDAYEDTGFSNEEILWK--ACGKDDTRQLLAGYD 2709
            :|.:|..|||.      ||..:..:.|...||..|         |.||  .....:.|.:|....
Human  2574 RPEEEFHVPLDSYRCQLFIQPAGILEHQYKESTTY---------ISWKEELHRSREVRCMLQCPS 2629

  Fly  2710 TNKSILYTFVN-------ISREIYHCKEQNLPGHKITLLPPLKINNMLCCDLMF------KIHEH 2761
            ...|.|...||       :|....|.::.:: .:.|.|.|.|.:.|:|...|.:      :.||.
Human  2630 VEVSFLPLIVNTVALPDELSYICTHGEDWDV-AYIIHLYPSLTLRNLLPYSLRYLLEGTAETHEL 2693

  Fly  2762 ATGRINSSESVNIYNVNICQPLNLSITLDNFQ---LSGQLKI--------PVSHRGVIEPKLKLI 2815
            |.|     .:.::.:..|...: :.:.|..:|   .:|..:|        ||.... ...::..:
Human  2694 AEG-----STADVLHSRISGEI-MELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSS-DSTEVTTV 2751

  Fly  2816 DIQKRELHVRVSIQSVPGKGMELYISAPVWIINKTGLPLIYKQEGTSHTAAGQFEEHETARQVAP 2880
            |:   .:|||..     |..|.|.:.:|.|:||||...|.|:.|.........|.:        .
Human  2752 DL---SVHVRRI-----GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRD--------I 2800

  Fly  2881 LMFSFSDQE--GSPALVLRLGKAYGSNNMWCKSFSTHKDLADRDLRAENTKGSYA---------- 2933
            ::|||..:.  ....:.|::     |.:.|..|||.            :|.|||.
Human  2801 ILFSFKKKNIFTKNKVQLKI-----STSAWSSSFSL------------DTVGSYGCVKCPANNME 2848

  Fly  2934 --IGISVRRGRGLYACTTFVTLSPRFHLHNRSGYKLEFMQLCDIVNYDRPDPRKIISAPVDCNFA 2996
              :|:|::...  :..:..|||:|...:.|:|..:||..::..  :...|..:....|..:|
Human  2849 YLVGVSIKMSS--FNLSRIVTLTPFCTIANKSSLELEVGEIAS--DGSMPTNKWNYIASSEC--- 2906

  Fly  2997 FHWPNWDQEQI--ICVRIPEIECCCWSKGIPIKDVQSLYINVRNEWGEMFFLRLEIISKDATFIL 3059
              .|.|.:...  :|||:  :.|...||                   ..|:.|     :|...:|
Human  2907 --LPFWPESLSGKLCVRV--VGCEGSSK-------------------PFFYNR-----QDNGTLL 2943

  Fly  3060 LFTDARTLPPPIRID-NCSE--VVINFSQLR--SKPVWITPVRPQSSLSYVMDDPLGQQILLMEA 3119
            ...|   |...|.:| |.:|  .||.||...  |.|..|....|...|:|
Human  2944 SLED---LNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTY--------------- 2990

  Fly  3120 PGGNMIEFPINNKNNIKKTLTYTNFIYIAFQGTFERSNEEENTHRQLVLGVRGKKVVIVEKNSGD 3184
                                                  ::..:..::||..|..::......:|.
Human  2991 --------------------------------------KQSGSPEEMVLLPRQARLFAWADPTGT 3017

  Fly  3185 RSQLWLMNSN-GQLEHE------GSTPPIQTNDAN-AVRLVLDLEKAPNPMEFTNLVVRTPNKQR 3241
            |...|...:| |  ||:      |..|    .||| .:..|..|:.....:.||:.|
Human  3018 RKLTWTYAANVG--EHDLLKDGCGQFP----YDANIQIHWVSFLDGRQRVLLFTDDV-------- 3068

  Fly  3242 VTTQTWRFENGRLMCHANMCVQSRFGESGLKPNYEAVVGR---TENRASSSKQIPIGQHIVAQKL 3303
                                               |:|.:   .|....:..:|.:..|.:...|
Human  3069 -----------------------------------ALVSKALQAEEMEQADYEITLSLHSLGLSL 3098

  Fly  3304 RPGSGQLELSTKMDGPISTIEICDIKIKQN-SVFLTPDLLWMHASLNNRQIT-DKGKVSFVHEYL 3366
            .....:.|:|  ..|..|:..:.::|.||. ..|....::.:..|....||: |.|.:...:.:.
Human  3099 VNNESKQEVS--YIGITSSGVVWEVKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFE 3161

  Fly  3367 INVELVKGIGISIIARKPCEEIMFIS-------LDHINCDIVQSALENSLDLNIAYIQIDNQLLD 3424
            :|.:           :.|.|..:.|.       |..|..:..||:.:.||...:.::|:||||..
Human  3162 VNFD-----------KDPMEMRLPIRSPIKRDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPG 3215

  Fly  3425 AVSPIALH--TQTSNDLEETQNAVVLKLKMLPSPNK--NAIIFKYLTLDLKPSTASLEEKLILKV 3485
            |:.|:..|  ....:...:::....:.:.::...|:  ..:.|||..:        |.:::.||:
Human  3216 AMFPVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVLQFKYFMV--------LIQEMALKI 3272

  Fly  3486 -ASFLG-----------------YGKINRQN---LSVQYQFENTDDKPFLQDMKRYYFENLSIGA 3529
             ..|||                 ..|:.:|:   |:.:....:..|...|.     :||:..|..
Human  3273 DQGFLGAIIALFTPTTDPEAERRRTKLIQQDIDALNAELMETSMTDMSILS-----FFEHFHISP 3332

  Fly  3530 TQVRLS------AFTSSKLPVEL---HETK---KALGLTLIKFEDALIELDRYSDKLHFETMDVY 3582
            .::.||      ...|.|...|:   |...   |::|.||...:|.:.:|..|..:..|...|..
Human  3333 VKLHLSLSLGSGGEESDKEKQEMFAVHSVNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQL 3397

  Fly  3583 RKELKKHYINQ-VKWHAAAILGSVDFLGNPLGFANDLSEGVSGLIFEG----------------- 3629
            ...:.:||..| :|.....:|| :|.||||.|....|||||..|.:|.
Human  3398 IWSVVRHYSEQFLKQMYVLVLG-LDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVI 3461

  Fly  3630 SVKSLVKNVTHGISNSTAKLTETLSDSLGKVVLDDHDNETRQRILELQSNTSGGHLAAGLKGLGF 3694
            .|:||..:...|.:...:::|.::...|..:.:|....:.|:..|..|....|..||.|.||...
Human  3462 GVRSLFGHTVGGAAGVVSRITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLR 3526

  Fly  3695 GLLGGVTSIVRHTYDGATSDGVPGFLSGLGKGLVGTVTKPIIGVLDLASETASAVRETSRDSHRN 3759
            |::||||.|:....:||..:|..||..|:||||||.|.:|..|::|:||.|...::..:..:...
Human  3527 GVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEV 3591

  Fly  3760 APERKRLPRCVTGAPGGLLPLYSNRQSKGQQYL 3792
            :..|.  ||.:  ...|::..|..::|:|...|
Human  3592 SSLRP--PRLI--HEDGIIRPYDRQESEGSDLL 3620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps13D	NP_729825.2	Chorein_N	4..112	CDD:315323	38/115 (33%)
		VPS13	147..368	CDD:318996	65/244 (27%)
		VPS13_mid_rpt	<656..837	CDD:318998	31/182 (17%)
		VPS13	<2039..>2694	CDD:330393	147/750 (20%)
		SHR-BD	2836..3113	CDD:310922	66/297 (22%)
		VPS13	<3346..3802	CDD:330393	124/510 (24%)
VPS13C	NP_065872.1	Chorein_N	4..113	CDD:289396	37/108 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..176		2/25 (8%)
		VPS13	185..413	CDD:293513	64/244 (26%)
		VPS13_mid_rpt	613..833	CDD:293515	41/269 (15%)
		MRS6	1046..>2612	CDD:227376	344/1824 (19%)
		VPS13_mid_rpt	<1238..1368	CDD:293515	34/156 (22%)
		VPS13_mid_rpt	1690..1882	CDD:293515	42/221 (19%)
		SHR-BD	2764..3016	CDD:284143	69/367 (19%)
		WWE	3116..3181	CDD:295449	13/75 (17%)
		VPS13_C	3323..3500	CDD:293514	44/182 (24%)
		ATG_C	3507..3582	CDD:286423	32/74 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4159at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950