DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps13D and Vps13c

DIOPT Version :9

Sequence 1:	NP_729825.2	Gene:	Vps13D / 39448	FlyBaseID:	FBgn0052113	Length:	3919	Species:	Drosophila melanogaster
Sequence 2:	NP_796158.2	Gene:	Vps13c / 320528	MGIID:	2444207	Length:	3748	Species:	Mus musculus

Alignment Length:	4291	Identity:	867/4291 - (20%)
Similarity:	1630/4291 - (37%)	Gaps:	1013/4291 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRDLITWVLNTYLGKYLENLNSAQLSVALLSGEVELENIPIRKDALRSFNLPVEVTAGSIRKIK 65
            :|..::..:||.:||.|:||||.:||.:.:..|.|.|:|:.|:::||...::|.:|.||.|.|:.
Mouse     2 VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLT 66

  Fly    66 LQIPVRQFRTSPWCISIEGLFCIICPKNLDNWDYEKEK--LQDLEYK------LAVLDTAEAGWR 122
            |:||.:.........::|||:.::.|.....:|.|||:  |||::.|      .|:...||.|..
Mouse    67 LKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAEKEEKSLQDIKQKELCRIEEALQKAAEKGAH 131

  Fly   123 S------------------EKGKQMESYYFSSYNNW---------LKYGT---NMATNIIDNIEL 157
            |                  .|.|:.:.::...:...         .|..|   .:||.:|.|:::
Mouse   132 SGEFMYGLENLLYKDVKPGRKRKKHKKHFKKRFKGLDRSKDKPKEAKKDTFLEKLATQVIKNVQV 196

  Fly   158 KISDVHFRFEDIVDTGKSKICTGIKIGSLTAQSCDCDWTNGSYKMNNNE-MNYKLVELKELSVYW 221
            ||:|:|.::||.:...:..:..|:.:...:..:.:..||  ...:|..| :.||||:|..||.||
Mouse   197 KITDIHIKYEDDITDPERPLSFGVTLREFSLLTTNEHWT--PCILNEAEKIIYKLVKLDSLSAYW 259

  Fly   222 DLLHEDIKCQSY--SNQEILEKMH-----STCELRSHNFIIKPICATAR-WKRDKCQQVIRTKDK 278
            ::    ..|.||  |.:.|||::.     ||.....|.:|.:||.|:|: :.....:..::|
Mouse   260 NV----GCCMSYRGSREHILEQLKREILTSTNIPPDHQYIFQPISASAKLYMNPGAESELKT--- 317

  Fly   279 PRVSCELLVPEVVIDISKVQRLQMLDKLSEIRQVKEVRQYRLKRPTCTVESNPIAWWKYATICHG 343
            |::...:.|..:.|:::|.|.|.|:|.|..:..:.....||..:|...:.:|...|||||
Mouse   318 PKLDGNVEVQNIAIELTKPQYLSMIDFLESLDYMVRNAPYRKYKPCLPLHTNCRQWWKYA----- 377

  Fly   344 FD------FKKNEEKW---------LMLKENLRYMLLYKSIILNPNENLSAADKEFKAYIESDRK 393
            .|      .::..:.|         .:||.   |.:.||:.:..     :...:|.:..|:...|
Mouse   378 IDSVLEVHIRRYTQPWSWSNIKNHRQLLKS---YKMAYKTKLTQ-----AKVSEEIQKQIQDLEK 434

  Fly   394 ---ISDLTIMRRICFEKVFTKGFAFESQN-EQGKNMLFHWFPNWMGWYANSPSTPNNEQDESLKH 454
               :.::.::|:....:|...|.....:: |.|:..  .||..:.|    ...:...:::.|:..
Mouse   435 SLDVFNIILVRQQAQVEVIHSGQKLRKKSAEAGEKR--GWFSGFWG----KKESKKRDEESSVPE 493

  Fly   455 LEDDILVALENS--------LQNSSDLKSDAVF-GH-FSIKLLKGLVILQTEDKLNDGRN--KSM 507
            ..||::...|..        .:|:.:|.....: .| .::||:...:|::      :.||  :.:
Mouse   494 TIDDLMTPEEKDKLFTAIGYSENAYNLALPKQYVAHILTLKLVSTSIIIR------ENRNVPEIL 552

  Fly   508 EMQFNNFSAYLQLSPQLTSYTVGISLQEVYLIDKTSSDTMHNYLIKPQTGNTATPNQLVKNAALQ 572
            .:|.......:...|...:..:...|:..|:......|.:.:  :....|:|.  :.|:|
Mouse   553 RVQIIGLGTQVSQRPGAQALKIEAKLEHWYVTGLRQQDIVPS--LVASIGDTT--SSLLK----- 608

  Fly   573 EDILFQLQYENCNHLRFQLNIKSKGLDLIYNEDAIQWLLDFLADSNSFKYSP-RNRVAKKTDFMK 636
              |.|:...|| :.....|.::|:.:::||:...|..:::|...:....... .:....|.:.:|
Mouse   609 --IEFETNPEN-SPADQTLIVQSQPVEVIYDAKTINAVVEFFQSNKGLDLEQITSATLMKLEEIK 670

  Fly   637 NWNEMFSGNEV-NRKIWMFEIEIFAPRIIFLE---NYKVSNSLMVLLDFGKLEMRKMEVKRVIPV 697
            ........:.: .||:....|.:....:|..:   :::.||  :::||||..::.
Mouse   671 ERTATGLTHIIETRKVLDLRINLKPSYLIIPQTGFHHEKSN--LLILDFGTFQLN---------- 723

  Fly   698 IESAVTENTSDDDETYLTPCSTPPASEKSGSESPTLLENPKTESFLNKNVQLEYVLHNKIYDKYL 762
                                     |:..|::        ||     .|..||.:: :|.|||:.
Mouse   724 -------------------------SKDQGAQ--------KT-----ANASLEEII-DKAYDKFD 749

  Fly   763 INFTNLQVLVCKYEERWQAC-LKTSSNFHLIDKFNINLTLEQRNIFTVDPEYPSFMLFGTCPTIL 826
            :...::|:|..|.||.|:.| .:..|..|::...:|::.|.:..: ..|.....|.:.|..|.:.
Mouse   750 VEIRSVQLLFAKAEENWKKCRFQHPSTMHILQPMDIHVELAKAMV-EKDVRMAKFKVSGGLPLMH 813

  Fly   827 IHGNEELINNCCNIMK--------------------PIIKA----------------SKEMENIY 855
            :..:::.|.:...::.                    |::..                |:..|..:
Mouse   814 VRISDQKIKDALCLINSIPLPQKSSTPSPERQVASIPVLSGGTKALLGTSLLLDGVESESDEEFF 878

  Fly   856 -------RGGNTIYASERIKNLAE---DDRSRVVIEFVMDQLVIEMQSTERSIAELQIIGARAGL 910
                   :...|:.||| :|..||   ::...::::|.:.::|:|                   |
Mouse   879 DAEDGDSQAARTVKASE-LKKAAEVPNEELVSLLLKFEIKEVVLE-------------------L 923

  Fly   911 TKEPHETNISMSVHGLLLVDAIQSFGPD-----FELLVASH-RHVGMD--SLSGSLKHSAIVSPT 967
            ||:..|..       .:||..:...|.:     |:|...|: |.:.:|  .:.||.|....:..:
Mouse   924 TKQQKEEE-------TILVFNVTQLGTEATMRTFDLTAVSYLRKISLDYHDIKGSRKKPIHLISS 981

  Fly   968 SPGSPNFFDRATSPHMITKAVQNIKMGDRSTEFCDDEDSTALISVDIKIVPPNESNSMQLHTTSI 1032
            |       ||   |.:....|:.||:......|....:.|.                   .|..:
Mouse   982 S-------DR---PGLDLLKVEYIKVDRNGPSFQTTFEKTE-------------------QTVKV 1017

  Fly  1033 TFNSLDIIANQDTIIEILNFAKRTLLAQNIFPSESPES---------PKEATEAPVDVVDQVDHK 1088
            .|:||:::.....::..||:      ...:.||:|..:         |::...:|:..| .|..:
Mouse  1018 AFSSLNLLLQTQALLSSLNY------LTTVIPSDSQNTGVAKEVQAMPEKQKNSPLQKV-MVPSR 1075

  Fly  1089 SHNEIFFDFF-RLNILLLYTIKRDKFNVGRKVGTVTLTEAKI-----NASFQS-DLSIIGSLGGI 1146
            ..:.|.|..| :||...: |:..:|.|:         .|.||     :.|.|| ..|:...|..|
Mouse  1076 DSDVIGFRLFAKLNAFCV-TVCDEKSNI---------AEIKIQGLDSSLSLQSKKQSLFARLENI 1130

  Fly  1147 QVIDITSEAFCHPRILSVGRDQILRASDTNKQTVLSQLSNEIYSNN---YNEETKSDESDAISFQ 1208
            .|.|:..:.. |.:.:|:                   :.||::..|   |.:.|:.|.
Mouse  1131 IVTDVDPKTI-HKKAVSI-------------------VGNEVFRFNLDLYPDATEGDS------- 1168

  Fly  1209 SHWSDKTTC--TFQMRMASASYTHCPRFLRDVNACITYF---KRSLREFATSIGNKATDMAKEFV 1268
              ::|.:|.  ...:.:......:..:||..:.:.:..|   |.:|.........||....|:..
Mouse  1169 --YTDMSTVDGVVALHVGCIQIVYLHKFLMSLLSFLNNFQVAKEALSAATAQAAEKAATSVKDLA 1231

  Fly  1269 QQVRAVEQIGPVYPQRNRQDNWLDIIISSPIIILPISNTSTNVLIANLGKISCSNAVKCDSDEFN 1333
            |:...|.               :||.:.:|:|::|.|:.|||.::.:||.|...|.....|.|
Mouse  1232 QRSFRVS---------------VDIDLKAPVIVIPQSSLSTNAVVVDLGLIRVHNRFSLVSGE-- 1279

  Fly  1334 ESYTIEIKNTYVYSLNIDEGEYSFN--------VHPAKNKDAIPILHDTAITLQLYAGYSDDNDE 1390
                 :..|..|    ||:.|....        :.|..:...|.:||  .|.|:.:...:...:.
Mouse  1280 -----DTANPPV----IDKMEVQLTKLKLSRTAIQPGTSHPDIQLLH--PINLEFFVSRNLAANW 1333

  Fly  1391 DKQLNRFSIKGSMVEALKVSLNRKQYELLLESIRYATNFSNEVLNE-SDELDQNGDIEPTANIDA 1454
            ..::....|||.: :::.||||::...||...:......:.|.|:: ...:.:.|:.:....:..
Mouse  1334 YHKVPVVEIKGRL-DSMNVSLNQEDLNLLFRILAENLGEATEDLDKGKPRIQERGETKACREVST 1397

  Fly  1455 ESIISTTIQFSVPVFQINLQNEYHNDLINLTFKNFNVKHISKGFDKDVEVVLKSVLMEDLKSDLT 1519
            ...:.||  ..||..::  :.....|:||:.. ||.:|          |||:..:...:.|.
Mouse  1398 PQDVHTT--QGVPAARV--EETRPVDIINVLL-NFEIK----------EVVVTLMKKAERKG--- 1444

  Fly  1520 SPFRNM-VTSVDLEQKIKKNEMTSSSCPDLPSYCNSLKNRSSSVPSCFYNHMQVKVFGGDQKYTS 1583
            |||..: :..:.:|.|:|.::||::      :|..::..|....|......:::
Mouse  1445 SPFHELKILHLGMEAKVKAHDMTAA------AYLRNISMRCFHFPDSKGEPLRI----------- 1492

  Fly  1584 SNKNELGKKKESQTLVIYKSHTGRSAQ--NGKLEQTSSIQFNCLNLAICVERWYTIFDFFGLV-- 1644
            .|.:::......:.|.|.....|...:  :...:|...:.|:.|:|.:.:|...::.||....
Mouse  1493 VNTSDVSDGILLKLLFIKADSDGPDFKTIHDNTKQKLKVSFSSLDLVLHLEALLSLMDFLSSAIP 1557

  Fly  1645 -SVDNVNEKYPEEMKLVEKH----IDKVCS---------KLKVSIRSFNFTLIRNESLLSRVNVS 1695
             |..:.:||.||...||.:.    |..|.|         |:...:.:||..:...:|.::.:.:.
Mouse  1558 SSDSSSSEKEPELKPLVGESRSLAIRAVPSSYEGDAFDLKITAELNAFNIFICDQKSNIAEIKIH 1622

  Fly  1696 NAVFMILQDPYSKIVEGCLGSVSVNDLTKYGNIYKQKFLTSGTEALNFVYKKKLVDLEALNTLD- 1759
            .....|...|....|...|.::.|.::... :|:|:.....|.|...|.........|..|..|
Mouse  1623 GMDASISVKPKQTDVFARLKNIIVMNVDSL-SIHKKAVSILGDEVFRFQMSLYPDATEGENYGDM 1686

  Fly  1760 --TDSTLRINMSAVHYIHTKRFSTELHVFVKDLL----QLQTPVIRKLKKHGSE-QNMRPSKMKL 1817
              .|..|.:.:..:..::..:|...|..|:.:..    .|.|..::..::..|. :::.....:|
Mouse  1687 SKVDGRLSLKVGCIQIVYVHKFFMSLLSFLNNFQAAKEALSTATVQAAERAASSVKDLAQKSFRL 1751

  Fly  1818 VIQAD--SPVIVLPSSYNRNEVIIAYLGQFSLKNSFHFASDNNIISKMSATPSKDEILDVMRIDL 1880
            ::..|  :|||.:|.|.....|:||.||...::|.|...|    :.:::..|..||    |.|.|
Mouse  1752 LMDIDLKAPVITIPQSSVSPNVVIADLGLIRVENKFSLVS----VEQLALPPVADE----MSIQL 1808

  Fly  1881 VNINLFSGERSSMKAKADQEKDRIIIADMNFLRLGQPFFNESCFLHLQLERNLSADAHRVCPDIS 1945
            ..:.|   .|:.::|.:.|. |..|:..:|.|              |.::|||||..:...|.:.
Mouse  1809 TQLKL---ARTVLQADSPQH-DVEILKPVNML--------------LCIQRNLSAAWYTQIPGME 1855

  Fly  1946 VQGTFSKLSGIINIQQYKLIRSFLNNNIGEQTDDIYMNYHNNSCTSIER--------LSTINLM- 2001
            ::|....:...::.....::...|..|:||.:.......:......::|        |....|.
Mouse  1856 IKGELKPMQVALSQDDLTVLMKILLENLGEASSQPSPTQYAQEAARVKRDTRSGPDYLKEQELAD 1920

  Fly  2002 PKNEVSKIVSILISIRILLEDVSLLLALNTSQSAAIEPLACIH---FLKSTLEIDL-------FS 2056
            ||....:.|::.....  .:.:|::| .|:..|.  ||....|   |....|.:.|       |.
Mouse  1921 PKPPGDQTVTLQFDFH--FDSLSIIL-YNSDSSQ--EPRLSFHNDSFRLGELTLHLMASAGKMFK 1980

  Fly  2057 DGSQDIDLISSNILIVDERNESDKSNENVFKNILEPSKKEVRIENSVQVEVHCRKKATFSKYTIM 2121
            |||.::.|......:.|.|...:::...:.      .||..:..||..:::...:....|:...:
Mouse  1981 DGSMNVSLKLKTCTLDDLREGIERATSRMI------DKKNDQDNNSSMIDISYSQDKNGSQVDAV 2039

  Fly  2122 LNNMRVFALLSFLDQLKSYLQEDSP-----------APVVNNAANQIAQKPQIDTSISTEYVVN- 2174
            |:.:.|.|.:.||..:..:..:..|           .|....||.::  |.:.|.|:.....:.
Mouse  2040 LDKLYVCASVEFLMTVADFFIKAMPQSPENIAKEIQIPSRQTAAGRV--KMEKDDSVRPNMTLKA 2102

  Fly  2175 -ITDSEIIFAEECSRLDSNAIILKSTTVICYKPNSNIVPLSLDINHLEIFSCTLDAEE--ESALS 2236
             |||.|::|....::.|:.|:.......:....:.....:...:..|::.:|....|.  :|..:
Mouse  2103 MITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACPFLRERRGKSITT 2167

  Fly  2237 IIDPFTLIIELRSNC--------LNILIQKHLNIRLSYVDVK-LFSRMARLLPTQTSRPKNVISK 2292
            ::.|.:|.:|   .|        :||:: |...|::|.:.:. :.:.||.:.|           |
Mouse  2168 VLQPCSLFME---KCTWASGKQNINIVV-KEFVIKISPIILNTVMTIMAAMSP-----------K 2217

  Fly  2293 ADSDLEKAAPLVAMGFEISDCLYAMQ----INNWRIN-DAAIWLSQQKQNTYRNPALEMKTAVVD 2352
            ...|..|..|      :.:|.|:|::    .|:|.:. |.|..:::..::: .:|::| :..||.
Mouse  2218 TKEDEWKDTP------KETDNLWAVKSITDYNSWFLGVDMATEVTENFRDS-EHPSIE-ENCVVA 2274

  Fly  2353 ASLISVFIIDDCMDADVPLLEVSLSKFLLNFTFQTQDPNPKETNIRHYS---LGNIDTEVSVNYY 2414
            ...:.|.:........|||| ::.|||              ..||::::   ....|..:.|:||
Mouse  2275 VESVQVTLECGLGHRTVPLL-LAESKF--------------SGNIKNWTSLMAAAADMTLEVHYY 2324

  Fly  2415 NRRLSGWEPVAETWESNLNW----KYTKGHLDNKK-----------RFEIGISSKQMLKLNVTST 2464
            |...:.|||:.|..|.|..|    ...|..:.:|.           :..:.|||...:.:.::.:
Mouse  2325 NETHAVWEPLIERVEGNKPWSLKLNVKKNPIQDKSLMPGDDFIPEPQTAVHISSGATMNITISKS 2389

  Fly  2465 FIELFHMVLKNWTNDFNDNGAKNF----RQRSPFIPFALQNLSGTPLLFKP--IYAPLGDLTRSD 2523
            .:.:|    .|....|::..|..|    :.|:   ||.::|..|.|:..:|  ....:|...:||
Mouse  2390 CLNVF----SNLAKGFSEGAASTFDYSLKDRA---PFTVKNALGVPMKVQPNRNLKVMGSPEKSD 2447

  Fly  2524 L------QQVELIKNWYSVQPNETKTFDFSQKSKLRHVHSHQLNLHQIFVQIHGWTLIGPISVDK 2582
            :      |.:||  ::.|::|        |::.||..:...:.:|..:....:|:|.:..:.|.:
Mouse  2448 IYDVGAGQHLEL--DYASLEP--------SRQGKLSILSRQESSLFTLTFVPYGYTEVASVPVAR 2502

  Fly  2583 VGMFFRTTKLDSQFLTKSRIV-FDISLIGSAQKLIKVKSSLGVIN---------KLDRNVFLKMT 2637
            .|......:..|...:.|.:| .|.:   ...|::.::|.|.:.|         |..:||.|
Mouse  2503 PGRRLYNVRNPSASHSDSVLVQIDAT---EGNKVVTLRSPLQIKNHFSIAFIIYKFVKNVKL--- 2561

  Fly  2638 LKGTHSDGLSSISVIKPNDELSVPLKFIDASLYV--AHNTSESDAYEDTGFSNEEILWKACGKDD 2700
                    |..|.:.:|.:|..|||......|||  |....:...:..|..|.:|.|.::   .:
Mouse  2562 --------LERIGIARPEEEFHVPLDSYRCQLYVQPAGGLEQQYTHSSTYISWKEELHRS---RE 2615

  Fly  2701 TRQLLAGYDTNKSILYTFVN-------ISREIYHCKEQNLPGHKITLLPPLKINNMLCCDLMF-- 2756
            .|.:|.......|.|...||       :|....|.::.: |.:.|.|.|||.:.|:|...|.:
Mouse  2616 VRCMLQCPAVEVSFLPLIVNTVALPDELSYIGAHGEDWD-PAYVIHLYPPLTLRNLLPYSLRYLL 2679

  Fly  2757 ----KIHEHATG--------RINSSESVNIYNV-----------NICQPLNLSITLDNFQL---S 2795
                :.||.|.|        || |.|.:.:..|           .||.      ||..|.|   |
Mouse  2680 EGTAETHELAEGSSADVLHSRI-SGEIIELVLVKYLGKNWNGHFRICD------TLPEFFLVCFS 2737

  Fly  2796 GQLKIPVSHRGVIEPKLKLIDIQKRELHVRVSIQSVPGKGMELYISAPVWIINKTGLPLIYKQEG 2860
            ..           ..::..:|:   .:|||..     |..|||.:.:|.|:||||...|.|:.|.
Mouse  2738 SD-----------TAEVMTVDL---SVHVRRI-----GCRMELSVFSPYWLINKTSRVLQYRSEE 2783

  Fly  2861 TSHTAAGQFEEHETARQVAPLMFSFSDQE--GSPALVLRLGKAYGSNNMWCKSFSTHKDLADRDL 2923
            ........|.:        .::|||..:.  ....:.|::     |.:.|...||.....:...:
Mouse  2784 IHVKHPADFRD--------IILFSFKKKNIFSKNKVQLKI-----STSAWSNGFSLDTVGSYGCV 2835

  Fly  2924 RAENTKGSYAIGISVRRGRGLYACTTFVTLSPRFHLHNRSGYKLEFMQLCDIVNYDRPDPRKIIS 2988
            :...|...|.:|:|::...  :..:..|||:|...:.|:|...||..::..  :...|..:....
Mouse  2836 KCPATNMEYLVGVSIKMSS--FNLSRVVTLTPFCTVANKSSLDLEVGEIAS--DGSIPTNKWHYV 2896

  Fly  2989 APVDCNFAFHWPNWDQEQI---ICVRIPEIECCCWSKGIPIKDVQSLYINVRNEWGEMFFLR--- 3047
            |..:| ..| ||    |.:   :|||:...|          ...:..:.| |.:.|.:..|.
Mouse  2897 ASSEC-IPF-WP----ENLSGKLCVRVVGYE----------GSSKPFFYN-RQDNGTLLSLEDLN 2944

  Fly  3048 ----LEIISKDATFILLFTDARTLPPPIRIDNCSEVVINFSQLRSKPVWITPVRPQSSLSYVMDD 3108
                ::|.:.:.:.::.|:|......|       .:::|.:|      |......||
Mouse  2945 GGILVDINTAEHSTVITFSDYHEGSAP-------ALIMNHTQ------WDVLTYKQS-------- 2988

  Fly  3109 PLGQQILLMEAPGGNMIEFPINNKNNIKKTLTYTNFIYIAFQGTFERSNEEENTHRQLVLGVRGK 3173
              |.|..|:..||...: |...:...|:| ||:.   |.|
Mouse  2989 --GSQEELVLLPGETRL-FAWADPTGIRK-LTWN---YAA------------------------- 3021

  Fly  3174 KVVIVEKNSGDRSQLWLMNSNGQLEHEGSTPPIQTNDAN-AVRLVLDLEKAPNPMEFTNLVVRTP 3237
                   |.|:..  .|.:..||..:          ||| .:..|..|:.....:.||:.|
Mouse  3022 -------NFGEHD--LLKDECGQFPY----------DANIQIHWVSFLDGRQRVLLFTDDV---- 3063

  Fly  3238 NKQRVTTQTWRFENGRLMCHANMCVQSRFGESGLKPNYEAVVGR---TENRASSSKQIPIGQHIV 3299
                                                   |:|.:   .|....:..::.:..|.:
Mouse  3064 ---------------------------------------ALVSKALQAEEMEQADHEVALSLHSL 3089

  Fly  3300 AQKLRPGSGQLELSTKMDGPISTIEICDIKIKQN-SVFLTPDLLWMHASLNNRQIT-DKGKVSFV 3362
            ...|.....:.|:|  ..|..|:..:.::|.||. ..|....::.:..:.:.|..: |:|.|...
Mouse  3090 GLSLVNNENKQEVS--YVGITSSGVVWEMKPKQKWKPFSQKQIMSLEQAYSKRLASQDRGWVKLD 3152

  Fly  3363 HEYLINVELVKGIGISIIARKPCEEIMFISLDHINCDIVQSALENSLDLNIAYIQIDNQLLDAVS 3427
            ..:.:|.:.|. :.:.:..|.|.:...   |..|..:..||..:.||...:.::|:||||...:.
Mouse  3153 SNFEVNFDKVP-MEMRLPIRCPIKRDF---LSGIQVEFKQSPHQRSLRARLYWLQVDNQLPGTMF 3213

  Fly  3428 PIALH--TQTSNDLEETQNAVVLKLKMLPSPNK--NAIIFKYLTLDLKPSTASLEEKLILKV-AS 3487
            |:..|  ....:...:::....:.:.::...|:  ..:.|||..:        |.:::.||| ..
Mouse  3214 PVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVLQFKYFMV--------LIQEMALKVDQG 3270

  Fly  3488 FLG-----------------YGKINRQN---LSVQYQFENTDDKPFLQDMKRYYFENLSIGATQV 3532
            |||                 ..|:.:|:   |:.:....:..|...|.     :||:..|...::
Mouse  3271 FLGAVISLFTPTTDPEAERKRTKLIQQDIDALNTELMESSMTDMSILS-----FFEHFHISPVKL 3330

  Fly  3533 RLSAFTSS---------KLPVELHETK---KALGLTLIKFEDALIELDRYSDKLHFETMDVYRKE 3585
            .||....|         :..:.:|...   |::|.||...:|.:.:|..|..:..|...|.....
Mouse  3331 HLSLSLGSGGEESDKEKQEMIAIHSVNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLMWS 3395

  Fly  3586 LKKHYINQ-VKWHAAAILGSVDFLGNPLGFANDLSEGVSGLIFEG-----------------SVK 3632
            :.:||..| :|.....:|| :|.||||.|....|||||..|.:|.                 .|:
Mouse  3396 VVRHYSEQFLKQMYVLVLG-LDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVR 3459

  Fly  3633 SLVKNVTHGISNSTAKLTETLSDSLGKVVLDDHDNETRQRILELQSNTSGGHLAAGLKGLGFGLL 3697
            |||.:...|.:...:::|.::...|..:.:|....:.|:..:..|....|..||.|.||...|::
Mouse  3460 SLVGHTVGGAAGVVSRITGSVGKGLAAITMDKEYQQKRREEMGRQPKDFGDSLARGGKGFLRGVV 3524

  Fly  3698 GGVTSIVRHTYDGATSDGVPGFLSGLGKGLVGTVTKPIIGVLDLASETASAVRETSRDSHRNAPE 3762
            ||||.|:....:||..:|..||..|:||||||.|.:|..|::|:||.|...::..:..:...:..
Mouse  3525 GGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIIDMASSTFQGIQRVAESTEEVSSL 3589

  Fly  3763 RKRLPRCVTGAPGGLLPLYSNRQSKGQQYLYLINQKNFSEKI----ISYEPNLWSDKEARL---- 3819
            |.  ||.:  ...|::..|..::|:|...|     :|..:|:    ..:...:..:|.|.|
Mouse  3590 RP--PRLI--HEDGIIRPYDRQESEGSDLL-----ENHIKKLEGEAYQFHCAVPGNKRAVLMITN 3645

  Fly  3820 RLLVSTEYVRIFSLSDANPTIMFECHVSEILSCHPVVTNAGTTPTTSSRASASHYIEISTNLPKI 3884
            |..:..:.|.|......:...:||..|     |.|                     |:|.||.||
Mouse  3646 RRALFIKEVEILGHMSVDWQCLFEDFV-----CPP---------------------EVSENLLKI 3684

  Fly  3885 T 3885
            :
Mouse  3685 S 3685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps13D	NP_729825.2	Chorein_N	4..112	CDD:315323	39/115 (34%)
		VPS13	147..368	CDD:318996	64/244 (26%)
		VPS13_mid_rpt	<656..837	CDD:318998	35/184 (19%)
		VPS13	<2039..>2694	CDD:330393	149/735 (20%)
		SHR-BD	2836..3113	CDD:310922	58/288 (20%)
		VPS13	<3346..3802	CDD:330393	122/511 (24%)
Vps13c	NP_796158.2	Chorein_N	4..113	CDD:289396	38/108 (35%)
		VPS13	185..414	CDD:293513	64/245 (26%)
		VPS13_mid_rpt	612..832	CDD:293515	47/272 (17%)
		VPS13_mid_rpt	<1236..1366	CDD:293515	36/158 (23%)
		MRS6	<1237..>2607	CDD:227376	309/1542 (20%)
		VPS13_mid_rpt	1687..1879	CDD:293515	45/217 (21%)
		SHR-BD	2759..3013	CDD:284143	63/311 (20%)
		WWE	3111..>3161	CDD:295449	9/49 (18%)
		VPS13_C	3318..3495	CDD:293514	43/182 (24%)
		ATG_C	3503..3577	CDD:286423	32/73 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4159at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950