Protein Alignment Vps13D and VPS13A

DIOPT Version :9

• Sequence 1: NP_729825.2
• Gene: Vps13D / 39448
• FlyBaseID: FBgn0052113
• Length: 3919
• Species: Drosophila melanogaster
• Sequence 2: NP_150648.2
• Gene: VPS13A / 23230
• HGNCID: 1908
• Length: 3174
• Species: Homo sapiens
• Alignment Length: 4082
• Identity: 743/4082 - (18%)
• Similarity: 1431/4082 - (35%)
• Gaps: 1291/4082 - (31%)

  Fly     1 MLRDLITWVLNTYLGKYLENLNSAQLSVALLSGEVELENIPIRKDALRSFNLPVEVTAGSIRKIK 65
            :...::..|||.:||.|:.:|:::|||:.:..|.|.|:|:.|:::||...::|.:|..|.|..:|
Human     2 VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGHIGNLK 66

  Fly    66 LQIPVRQFRTSPWCISIEGLFCIICPKNLDNWDYEKEKLQDLEYKLAVLDTAEAGWRSEKGKQ-- 128
            |.||.:...|.|....:|.::.:|.|.:...:|..||:.|.:|.|...|.      |.|:.||
Human    67 LIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELK------RIEEAKQKV 125

  Fly   129 --MESYYFSSYNNWLKYGTNMATNIIDNIELKISDVHFRFEDIVDTGKSKICTGIKIGSLTAQSC 191
              .|.:.....:.   :...:.|.||.|:::|||.:|.|:||.:......:..||.:.:|:.|:.
Human   126 VDQEQHLPEKQDT---FAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTT 187

  Fly   192 DCDWTNGSYKMNNNEMNYKLVELKELSVYWDLLHEDIKCQSYSNQEILEKMHSTCELRS------ 250
            |..|....:. ...::..||:.|..|..||::..:......|.|        |..:|::
Human   188 DQYWVPCLHD-ETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDN--------SLDDLKNGIVNEN 243

  Fly   251 -----HNFIIKPICATARWKRDKCQQVIRTKD----KPRVSCELLVPEVVIDISKVQRLQMLDKL 306
                 ::|:.:||.|.|:...:      |..|    .|:::.|:.:..:.|:.:|.|...:::.|
Human   244 IVPEGYDFVFRPISANAKLVMN------RRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIMELL 302

  Fly   307 SEIRQVKEVRQYRLKRPTCTVESNPIAWWKYATICHG-FDFKKNEEKWLMLKENLR--------Y 362
            ..:..:.:...||..:|...:..:...||.||  .|| .:.......|:...:::|        |
Human   303 ESVDMMAQNLPYRKFKPDVPLHHHAREWWAYA--IHGVLEVNVCPRLWMWSWKHIRKHRQKVKQY 365

  Fly   363 MLLYKSIILN---PNENLSAADKEFKAYIESDRKISDLTIMRRICFEKVFTKGFAFESQN----E 420
            ..|||..:.:   |.|.|.:.::     :|....:.::||.|:....:|...|:....:.    |
Human   366 KELYKKKLTSKKPPGELLVSLEE-----LEKTLDVFNITIARQTAEVEVKKAGYKIYKEGVKDPE 425

  Fly   421 QGKNMLFHWFPNWMGWYANSPSTPNNEQDESLKHLEDDILVALENSLQNSSDLKSDAVFGHFSIK 485
            ..|.. |.|..:|      |....|.:|.:......:::|...|.:|...:...|:.......:|
Human   426 DNKGW-FSWLWSW------SEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLK 483

  Fly   486 L---------LKGLVILQTEDKLNDGRNKSMEMQFNNFSAYLQLSPQLTSYTVGISLQEVYLIDK 541
            .         ||.:.|:..|   |..:.:.:::....||..:...|         ..|.:..  :
Human   484 TFEALKFFVHLKSMSIVLRE---NHQKPELVDIVIEEFSTLIVQRP---------GAQAIKF--E 534

  Fly   542 TSSDTMHNYLIKPQTGNTATPNQLVKNAALQEDI-LFQLQYENCNHLRFQLN----IKSKGLDLI 601
            |..|:.|   |.....|:..|..|   ::|.:.: |||:.:| .|.|...::    |:::.|::|
Human   535 TKIDSFH---ITGLPDNSEKPRLL---SSLDDAMSLFQITFE-INPLDETVSQRCIIEAEPLEII 592

  Fly   602 YNEDAIQWLLDFLADSNSFKYSPRNRVAKKTDFMKNWNEMFSGNEVNRKIWMFEIEIFAPRIIFL 666
            |:...:..:::|      |:......:|:.|.......|.|........:::.|.:    :::.|
Human   593 YDARTVNSIVEF------FRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQ----KVLDL 647

  Fly   667 E-NYKVS------------NSLMVLLDFGKLEMRKMEVKRVIPVIESAVTENTSDDDETYLTPCS 718
            : |.|.|            .|.::|||.|.|::
Human   648 KINLKASYIIVPQDGIFSPTSNLLLLDLGHLKV-------------------------------- 680

  Fly   719 TPPASEKSGSESPTLLENPKTESFLNKNVQLEYVLHNKIYDKYLINFTNLQVLVCKYEERWQACL 783
                :.||.||.|.:.:.   |:.|.:       :.::.||.:.|..|::|:|..:..:.|:...
Human   681 ----TSKSRSELPDVKQG---EANLKE-------IMDRAYDSFDIQLTSVQLLYSRVGDNWREAR 731

  Fly   784 KTS-SNFHLIDKFNINLTLEQRNIFTVDPEYPSFMLFGTCPTILIHGNEELINNCCNIMKPIIKA 847
            |.| |..|::...:.||.|.:..:| :|...|.|.::|..|.|.:..:::.:.....:::.|.|.
Human   732 KLSVSTQHILVPMHFNLELSKAMVF-MDVRMPKFKIYGKLPLISLRISDKKLQGIMELIESIPKP 795

  Fly   848 SKEMENIYRGGNTIYASERIKNLAEDDRSRVVIEFVMDQLVIEMQSTERSIAELQIIGARAGLTK 912
            ....|          .|..:|:                   .::| |..|:...|
Human   796 EPVTE----------VSAPVKS-------------------FQIQ-TSTSLGTSQ---------- 820

  Fly   913 EPHETNISMSVHGLLLVDAIQSFGPDFELLVASHRHVGMDSLSGSLKHSAIVSPTSPGSPNFFDR 977
                  ||..:..||.:.::.....:.|...|                     |.||
Human   821 ------ISQKIIPLLELPSVSEDDSEEEFFDA---------------------PCSP-------- 850

  Fly   978 ATSPHMITKAVQNIKMGDRSTEFCDDEDSTALISVDIKIVPPNESNSMQLHTTSITFNSLDIIAN 1042
            ...|......|::|:......:.|                      |:.:.|..|.|
Human   851 LEEPLQFPTGVKSIRTRKLQKQDC----------------------SVNMTTFKIRF-------- 885

  Fly  1043 QDTIIEILNFAKRTLLAQNIFPSESPESPKEATEAPVDVVDQVDHKSHNEIFFDFFRLNILLLYT 1107
                                      |.||                    :..:|:.|
Human   886 --------------------------EVPK--------------------VLIEFYHL------- 897

  Fly  1108 IKRDKFNVGRKVGTVTLTEAKINASFQSDLSIIGSLGGIQVIDITSEAFCHPRILSVGRDQILRA 1172
                       ||             ..:||::..|                 :|.:|.:..:|.
Human   898 -----------VG-------------DCELSVVEIL-----------------VLGLGAEIEIRT 921

  Fly  1173 SDTNKQTVLSQLSNEIYSNNYNEETKSDESDAISFQSHWSDKTTCTFQMRMASASYTHCPRFLRD 1237
            .|......|                                |..|           ..||.:| |
Human   922 YDLKANAFL--------------------------------KEFC-----------LKCPEYL-D 942

  Fly  1238 VNACITYFKRSLREFATSIGNKATD-MAKEFVQQVRAVEQIGPVYPQRNRQDNWLDIIISSPIII 1301
            .|....|       ..|::.|...| :..|:|:..:.|..:...|      :|.|.:|
Human   943 ENKKPVY-------LVTTLDNTMEDLLTLEYVKAEKNVPDLKSTY------NNVLQLI------- 987

  Fly  1302 LPISNTSTNVLIANLGKISCSNAVKCDSDEFNESYTIEIKNTYVYSLNIDEGEYSFNVHPAKNKD 1366
             .::.:|.::.:                      :|..:.||.         .|..|:.|...:.
Human   988 -KVNFSSLDIHL----------------------HTEALLNTI---------NYLHNILPQSEEK 1020

  Fly  1367 AIPILHDTAITLQLYAGYSDDNDEDKQLNRFSIKGSMVE--ALKVSLNRKQYELLLESIRYATNF 1429
            :.|:              |....||        ||.:::  |||:|.|
Human  1021 SAPV--------------STTETED--------KGDVIKKLALKLSTN----------------- 1046

  Fly  1430 SNEVLNESDELDQNGDIEPTANIDAESIISTTIQFSVPVFQINLQNEYHNDLINLTFKNFNVKHI 1494
                                     |.||:..|...:...||.:|::..| :..:..:..:.:.|
Human  1047 -------------------------EDIITLQILAELSCLQIFIQDQKCN-ISEIKIEGLDSEMI 1085

  Fly  1495 SKGFDKDVEVVLKSVLMEDLKSDLTSPFRNMVTSVDLEQKIKKNEMTSSSCPDLPSYCNSLKNRS 1559
            .:..:.::...|:::::  |.||:|:.::..|
Human  1086 MRPSETEINAKLRNIIV--LDSDITAIYKKAV--------------------------------- 1115

  Fly  1560 SSVPSCFYNHMQVKVFGGDQKYTSSNKNELGKKKESQTLVIYKSHTGRSAQNGKLEQTSSIQFNC 1624
                                 |.:      ||:..|..:|.|...|..||
Human  1116 ---------------------YIT------GKEVFSFKMVSYMDATAGSA--------------- 1138

  Fly  1625 LNLAICVERWYTIFDFFGLVSVDNVNEKYPEEMKLVEKHIDKVCSKLKVSIRSFNFTLIRNESLL 1689
                      ||                   :|.:|:..::
Human  1139 ----------YT-------------------DMNVVDIQVN------------------------ 1150

  Fly  1690 SRVNVSNAVFMILQDPYSKIVEGCLGSVSVNDLTKYGNIYKQKFLTSGTEALNFVYKKKLVDLEA 1754
                               ::.||:..|.|.           |||.|   .|.|:     .:.:|
Human  1151 -------------------LIVGCIEVVFVT-----------KFLYS---ILAFI-----DNFQA 1177

  Fly  1755 LNTLDTDSTLR-INMSAVHYIHTKRFSTELHVFVKDLLQLQTPVIRKLKKHGSEQNMRPSKMKLV 1818
            ......::|:: ..|:|..              ||:|.|                  |.|:|.|.
Human  1178 AKQALAEATVQAAGMAATG--------------VKELAQ------------------RSSRMALD 1210

  Fly  1819 IQADSPVIVLPSSYNRNEVIIAYLGQFSLKNSFHFASDNNIISKMSATPSKDEILDVMRIDLVNI 1883
            |...:||:|:|.|.....|.:|..|..::.|:||..::    |:.|..|    ::|::.|.|..:
Human  1211 INIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITE----SQSSPPP----VIDLITIKLSEM 1267

  Fly  1884 NLFSGERSSMKAKADQEKDRIIIADMNFLRLGQPFFNESCFLHLQLERNLSADAHRVCPDISVQG 1948
            .|:   ||.....|.||     :.|: .|.|.         |.:.:||||..:.::..|..:|..
Human  1268 RLY---RSRFINDAYQE-----VLDL-LLPLN---------LEVVVERNLCWEWYQEVPCFNVNA 1314

  Fly  1949 TFSKLSGIINIQQYKLIRSFLNNNIGEQTD---------DIY---------MNYHNNSCTSIERL 1995
            ....:..|::.:....|...|:.||..:.|         |.|         .::|:...|.:
Human  1315 QLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSGVTTNASHHSGGATVV--- 1376

  Fly  1996 STINLMPKNEVSKIVSILISIRILLEDVSLLLALNTSQSAAI----EP-LACIHF----LKSTLE 2051
             |..::..:..:.:|...::|....:|::::|.....:.|:.    :| |....|    :.|||:
Human  1377 -TAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLK 1440

  Fly  2052 IDLFSDGSQDIDLISSNILIVDERNESDKSNENVFKNILEPSKKEVRIENSVQVEVHCRKKATFS 2116
              :::|||........|.::.|:|....|:...:....:...||::......:|...|...|.|.
Human  1441 --MYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDAVFQ 1503

  Fly  2117 KYTIMLNNMRVFALLSFLDQLKS-YLQEDSPAPVVNNAANQIAQKPQIDTSISTEYVVN--ITDS 2178
            :       |.:.|.:.||..:.: :|:..:....|..:......|.::.|..|.::.:|  |.:.
Human  1504 E-------MYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEVPTQESVKWEINVIIKNP 1561

  Fly  2179 EIIFAEECSRLDSNAIILKSTTVICYKPNSNIVPLSLDINHLEIFSCT-LDAEEESAL-SIIDPF 2241
            ||:|..:.::.|:.|:::.:...||||.|.....::..|..|::.:|. |..:.:..: :::.|.
Human  1562 EIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPC 1626

  Fly  2242 TLIIELRS-----NCLNILIQKHLNIRLSYVDVK-LFSRMARLLPTQTSRPKNVISKADSDLEKA 2300
            .|..:...     ..:::.: |.|.:::|.|.:. :.:..:.|..|:.:.|:...|..
Human  1627 DLFYQTTQKGTDPQVIDMSV-KSLTLKVSPVIINTMITITSALYTTKETIPEETASST------- 1683

  Fly  2301 APLVAMGFEISDCLYAMQINNWRINDA---AIWLSQQKQNTYR-NPALEM--KTAVVDASLISVF 2359
                              .:.|...|.   .:|..::...|.: .|..|:  |..::..::.|:|
Human  1684 ------------------AHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGEMIKMNIDSIF 1730

  Fly  2360 IIDDCMDA-----DVPLLEVSLSKFLLNFTFQTQDPNPKETNIRHYSLGNIDTEVSVNYYNRRLS 2419
            |:   ::|     .||:|       |....|..:..|.......|..|     |:.|:|||....
Human  1731 IV---LEAGIGHRTVPML-------LAKSRFSGEGKNWSSLINLHCQL-----ELEVHYYNEMFG 1780

  Fly  2420 GWEPVAETWES---------NLNWKYTK----------GHLDNKK----RFEIGISSKQMLKLNV 2461
            .|||:.|..|.         ||..|..|          ...:|.|    :..|...||..|.:.:
Human  1781 VWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQLNITL 1845

  Fly  2462 TSTFIELFHMVLKNWTNDFNDNGAKNFRQRSPFIPFALQNLSGTPLLFKPIYAPLGDLTRSD--- 2523
            :...:.:.:.::|.:|.....:.|...:..:||:   :.|..|..:...|          ||
Human  1846 SKCGLVMLNNLVKAFTEAATGSSADFVKDLAPFM---ILNSLGLTISVSP----------SDSFS 1897

  Fly  2524 LQQVELIKNWYSVQPNETKTFDFSQKSKLRHVHSHQLNLHQIFVQIHGWTLIGPI---SVDKVGM 2585
            :..:.:.|: |.::..|:.:.|:.:.....|.::......::|     :.|:.|:   :.||:.:
Human  1898 VLNIPMAKS-YVLKNGESLSMDYIRTKDNDHFNAMTSLSSKLF-----FILLTPVNHSTADKIPL 1956

  Fly  2586 FFRTTKLDSQFLT--------KSRIVFDISLIGSAQKLIKVKSSLGVIN--KLDRNVFLKMTLKG 2640
                ||:..:..|        :..||..|..:..::| :.::|.:.:.|  .:..:|:...||.|
Human  1957 ----TKVGRRLYTVRHRESGVERSIVCQIDTVEGSKK-VTIRSPVQIRNHFSVPLSVYEGDTLLG 2016

  Fly  2641 THSDGLSSISVIKPNDELSVPLKFIDASLYVAHNTSESDAYE-DTGFSNEEILWKACGKDD---- 2700
            |.|          |.:|.::||....:.:::   ..|.:.|: ..|...|||:     |:|
Human  2017 TAS----------PENEFNIPLGSYRSFIFL---KPEDENYQMCEGIDFEEII-----KNDGALL 2063

  Fly  2701 TRQLLAGYDTNKSILYTFV----NI-SREIYHCKEQNLPGHKITLLPPLKINNMLCCDLMFKIHE 2760
            .::..:...:.:|.|...|    |: |..:|.....:|| :.:.|.||:.:.|:    |.:||..
Human  2064 KKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWDLP-YIMHLWPPILLRNL----LPYKIAY 2123

  Fly  2761 HATGRINS----SESVNIYNVNICQPLNLSITLDNFQLSGQLKIPVSHRGVIEPKLK-------- 2813
            :..|..||    ||.   ::..||     :..|...:|..:|...::|....|..:|
Human  2124 YIEGIENSVFTLSEG---HSAQIC-----TAQLGKARLHLKLLDYLNHDWKSEYHIKPNQQDISF 2180

  Fly  2814 -----LIDIQKRELHVRVSIQSVPGKGMELYISAPVWIINKTGLPLIYKQEGTSHTAAGQFEEHE 2873
                 :.:::|.:|.:.|.:....|:.:..:.| |.|::||||..|.||.:|........:::
Human  2181 VSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHS-PYWMVNKTGRMLQYKADGIHRKHPPNYKK-- 2242

  Fly  2874 TARQVAPLMFSFSDQE--GSPALVLRLGKAYGSNNMWCKSFSTHKDLADRDLRAENTKGSYAIGI 2936
                  |::|||....  .:..:.|.:..:..||.....:..:|     ..::.:..|..|.:|:
Human  2243 ------PVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH-----GAVKCKGLKMDYQVGV 2296

  Fly  2937 SVRRGRGLYACTTFVTLSPRFHLHNRSGYKLEFMQLCDIVNYDRPDPRKIISAPVDCNFAFHWPN 3001
            ::  ....:..|..||.:|.:.:.|:|.|.:.       |..:..|  |.:|..::....| ||.
Human  2297 TI--DLSSFNITRIVTFTPFYMIKNKSKYHIS-------VAEEGND--KWLSLDLEQCIPF-WPE 2349

  Fly  3002 WDQEQIICVRIPEIECCCWSKGIPIKDV------QSLYINVRNEWGEMFFLRLEIISKDATFILL 3060
            :...::: :::...|       .|.|.:      ..:.:.:.||.|.:.   .|:...:.:.::.
Human  2350 YASSKLL-IQVERSE-------DPPKRIYFNKQENCILLRLDNELGGII---AEVNLAEHSTVIT 2403

  Fly  3061 FTD----ARTLPPPIRIDNCSEVVINFSQLRSKPVWITPVRPQSSLSYVMDDPLGQQIL------ 3115
            |.|    |.|.   :.|::....::.::|.....: ...:.|..::.|...||:|.:.|
Human  2404 FLDYHDGAATF---LLINHTKNELVQYNQSSLSEI-EDSLPPGKAVFYTWADPVGSRRLKWRCRK 2464

  Fly  3116 -----------LMEAPGGNMIEFPINNKNNIKKTLTYTNFIYIAFQGTFERSNEEENTHRQLVLG 3169
                       :|....|....:.::....:::.:.:|....: |:.|:| |.:.|...:::.:.
Human  2465 SHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRV-FKVTYE-SEKAELAEQEIAVA 2527

  Fly  3170 VRGKKVVIVEKNSGDRSQLWLMNSNGQLEHEGSTPPIQTNDANAVRLVLDLEKAPNPMEFTNLVV 3234
            ::...:.:|               |...:.|.:...|.::|                     :|.
Human  2528 LQDVGISLV---------------NNYTKQEVAYIGITSSD---------------------VVW 2556

  Fly  3235 RTPNKQRVTTQTWRFENGRLMCHANMCVQSRFGESGLKPNYEAVVGRTENRASSSKQIPIGQHIV 3299
            .|..|::.   .|:..:.:   |... ::..|.|            .||:..|..|.|.:..::
Human  2557 ETKPKKKA---RWKPMSVK---HTEK-LEREFKE------------YTESSPSEDKVIQLDTNV- 2601

  Fly  3300 AQKLRPGSGQLELSTKMDGPISTIEICDIKIKQNSVFLTPDLLWMHASLNNRQITDKGKVSFVHE 3364
                                              .|.|||       :.:|.:|.....::....
Human  2602 ----------------------------------PVRLTP-------TGHNMKILQPHVIALRRN 2625

  Fly  3365 YLINVELVKGIGISIIARKPCEEIMFISLDHINCDIVQSALENSLDLNIAYIQIDNQLLDAVSPI 3429
            ||                 |..::.:.:          ||.::|..:.|..|||.||:..||.|.
Human  2626 YL-----------------PALKVEYNT----------SAHQSSFRIQIYRIQIQNQIHGAVFPF 2663

  Fly  3430 ALHTQTSNDLEETQNAVVLKLKMLPSPNKNAIIFKYLTLDLKPSTASLEEKLILKVA-----SFL 3489
            ..:                       |.|..   |.:|:|..|...: :..::::.|     |.:
Human  2664 VFY-----------------------PVKPP---KSVTMDSAPKPFT-DVSIVMRSAGHSQISRI 2701

  Fly  3490 GYGKINRQNLSVQYQF----------------ENTDDKPFLQDMKRY------------------ 3520
            .|.|:..|.:.::...                |||:.:.|.:|::.:
Human  2702 KYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIEAFKEEYKTASLVDQSQVSLY 2766

  Fly  3521 -YFE----------NLSIGATQVRLSAFTSSKLPV-ELHETKKALGLTLIKFEDALIELDRYSDK 3573
             ||.          :||.|..:.:.|......:|| .|:...|::|.||...:|.:.:|..:...
Human  2767 EYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQDVVFKLAFFELN 2831

  Fly  3574 LHFETMDVYRKELKKHYINQ-VKWHAAAILGSVDFLGNPLGFANDLSEGVSGLIFE---GSV--- 3631
            ..|.|....:.|:.:||..| :|.....||| :|.||||.|...:.||||....:|   |::
Human  2832 YQFHTTSDLQSEVIRHYSKQAIKQMYVLILG-LDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGP 2895

  Fly  3632 -----------KSLVKNVTHGISNSTAKLTETLSDSLGKVVLDDHDNETRQRILELQSNTSGGHL 3685
                       |:||.....|::.:.:|:|..::..:..:.:|:...:.|:..:..|.......:
Human  2896 EEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGI 2960

  Fly  3686 AAGLKGLGFGLLGGVTSIVRHTYDGATSDGVPGFLSGLGKGLVGTVTKPIIGVLDLASETASAVR 3750
            ..|.|||..|.:.|:|.||.....||...|..||..|:||||||.|.:|..|::|:||.|...::
Human  2961 TRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIK 3025

  Fly  3751 ETSRDSHRNAPERKRLPRCVTGAPGGLLPLYSNRQSKGQQYLYLINQKNFSE 3802
            ..:..|.   .|..|.||...  ..|::..|..|...|.|.|.::....|::
Human  3026 RATETSE---VESLRPPRFFN--EDGVIRPYRLRDGTGNQMLQVMENGRFAK 3072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps13D	NP_729825.2	Chorein_N	4..112	CDD:315323	36/107 (34%)
		VPS13	147..368	CDD:318996	54/244 (22%)
		VPS13_mid_rpt	<656..837	CDD:318998	38/194 (20%)
		VPS13	<2039..>2694	CDD:330393	138/721 (19%)
		SHR-BD	2836..3113	CDD:310922	54/288 (19%)
		VPS13	<3346..3802	CDD:330393	119/524 (23%)
VPS13A	NP_150648.2	MRS6	4..>2104	CDD:227376	516/2898 (18%)
		Chorein_N	4..113	CDD:289396	36/108 (33%)
		VPS13	142..371	CDD:293513	54/245 (22%)
		TPR 1	212..245		7/40 (18%)
		TPR 2	373..406		7/37 (19%)
		TPR 3	537..575		12/44 (27%)
		VPS13_mid_rpt	570..793	CDD:293515	52/280 (19%)
		FFAT. /evidence=ECO:0000269|PubMed:30741634	842..848		2/26 (8%)
		VPS13_mid_rpt	1156..>1266	CDD:293515	38/168 (23%)
		TPR 4	1256..1289		11/41 (27%)
		TPR 5	1291..1320		7/28 (25%)
		TPR 6	2009..2041		9/44 (20%)
		SHR-BD	2209..2452	CDD:284143	51/283 (18%)
		TPR 7	2568..2601		8/48 (17%)
		Required for mitochondrial localization. /evidence=ECO:0000269|PubMed:30741634	2615..3174		117/518 (23%)
		VPS13_C	2766..2943	CDD:293514	44/177 (25%)
		ATG_C	2946..3025	CDD:286423	29/78 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4159at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950