Protein Alignment Vps13D and VPS13B

DIOPT Version :9

• Sequence 1: NP_729825.2
• Gene: Vps13D / 39448
• FlyBaseID: FBgn0052113
• Length: 3919
• Species: Drosophila melanogaster
• Sequence 2: NP_060360.3
• Gene: VPS13B / 157680
• HGNCID: 2183
• Length: 4022
• Species: Homo sapiens
• Alignment Length: 4716
• Identity: 821/4716 - (17%)
• Similarity: 1507/4716 - (31%)
• Gaps: 1672/4716 - (35%)

  Fly     1 MLRDLITWVLNTYLGKYLENLNSAQLSVALLSGEVELENIPIRKDAL-RSFNLPVEVTAGSIRKI 64
            ||...:|.:|.:|:.:|::||..:.|.::|..|:|.|..:.::.|.| :...||....:|.|.::
Human     1 MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHEL 65

  Fly    65 KLQIPVRQFRTSPWCISIEGLFCII------------CPKNLDNWDYEKEKLQDLEYKLAVLDTA 117
            ::.:|..:..:.|..|:|..:.||:            |..|..|                 ..||
Human    66 RIHVPWTKLGSEPVVITINTMECILKLKDGIQDDHESCGSNSTN-----------------RSTA 113

  Fly   118 EAGWRSEKGKQMESYYFSSYNNWLKYGTNMATNIIDNIELKISDVHFRF--EDIVDTGKSKICTG 180
            |:...|.|.::|:....:..:....|..::...:::|:.:.|:::..::  :|||
Human   114 ESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIV---------- 168

  Fly   181 IKIGSLTAQSCDCDWTNGSYKMNNNEMNYKLVELKELSVYWDLLHEDIKCQSYSNQEILEKMHST 245
               .|:...|.:|               |.:.||      ||....||.......::::.....|
Human   169 ---LSVNITSAEC---------------YTVGEL------WDRAFMDISATDLVLRKVINFSDCT 209

  Fly   246 CELRSHN------FIIKPIC--ATARWKRDKCQQVIRTKDKPRVSCELLVPEVVIDISKVQRLQM 302
            ..|...|      |...|:.  .:.|.:.....:.:.:|....:....||..:.:.|:. |:|.|
Human   210 VCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITD-QQLPM 273

  Fly   303 LDKLSEI------RQVKEVRQYRLKRPTC----------------------------------TV 327
            ..::.::      .::...::..::..||                                  ..
Human   274 FIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQD 338

  Fly   328 ESNPIAW----WKYATICHGF-----DFKKN-------EEKWLMLKENLRYMLLY---------- 366
            |..|..|    |.:......:     ||..|       ::|...||:.:..:..|
Human   339 EEQPQGWVSWAWSFVPAIVSYDDGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKL 403

  Fly   367 -----KSIILNPN-----------------ENLSAADKEFKAYI-------------------ES 390
                 :|...:|.                 |.|...:..|...|                   |.
Human   404 TEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFVGCRAMCLKGIMGVKDFEE 468

  Fly   391 DRKISDLTIMRRICFEKVFTKGFAF----------------------------ESQNEQGKNMLF 427
            :...|:......||.:.:.||||.:                            |:..|......|
Human   469 NMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRF 533

  Fly   428 HWFPNWMGWYANSPST----PNNEQDESLKHLED------------------------------- 457
            ..|  :|.:.....:|    ..|:||.|....||
Human   534 GAF--YMDYLYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILK 596

  Fly   458 DILVALENSLQNSSDLKSD--------------AVF------GHFSIKLLK-GLVILQTEDKLND 501
            .|:.|||:..:..|.||||              |:.      .|.|:.||| ...|...|..|.|
Human   597 MIVCALEHEYEPYSRLKSDIKDENETILNPEEVALLEEYIPTRHTSVTLLKCTCTISMAEFNLLD 661

  Fly   502 --------GRNKSMEMQFNNFSAYLQLSPQLTSYTVGISL---------QEVYLIDKTS--SDTM 547
                    .:|.|..|...||.: |:..|.:......|:|         |.|:::...:  ||.:
Human   662 HLLPVIMGEKNSSNFMNTTNFQS-LRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNL 725

  Fly   548 HNY--------LIKPQTG--------------------NTATPNQLVK----------------- 567
            .:|        :...|.|                    :||...:|:|
Human   726 LHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGI 790

  Fly   568 ----NAALQ----EDILFQLQYENCNHLR----------------FQLNIKSK-----------G 597
                |..:|    :.:|.|..|::.:||.                ..:.:|||           .
Human   791 FELPNLTIQATRAQTLLLQAIYQSWSHLGNVSSSAVIEALINEIFLSIGVKSKNPLPTLEGSIQN 855

  Fly   598 LDLIYNEDAI-----------------------QWLLDFL------ADSNSFKYSPRNR------ 627
            ::|.|...::                       :.|:..|      .|.:|.|:...:|
Human   856 VELKYCSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHSTKWLNESRKPESLL 920

  Fly   628 ----------VAKKTDFMKNWNEM----FSGNEVNRKIWMFEIEIFAPRIIFLENYKVSNSLMVL 678
                      |.:..|:..|...:    ..|..||....::...|:.|:
Human   921 APDLMAFTIQVPQYIDYCHNSGAVLLCSIQGLAVNIDPILYTWLIYQPQ---------------- 969

  Fly   679 LDFGKLEMRKMEVKRVIPV-IESAVTENTSDDDETYLTPCSTPPASEKSGSESPTLLENPKTESF 742
                |...|.|:.:.|:.| :...|.....|:    ::..|.|.|.::|...|          .:
Human   970 ----KRTSRHMQQQPVVAVPLVMPVCRRKEDE----VSIGSAPLAKQQSYQAS----------EY 1016

  Fly   743 LNKNVQLEYVLHNK---IYDKYLINFTNLQVLVCKY-EER--------WQACLKTSSNFHLIDKF 795
            .:..|:.:.|..::   :..|.::|.:.    .|:. |||        |.|..
Human  1017 ASSPVKTKTVTESRPLSVPVKAMLNISE----SCRSPEERMKEFIGIVWNAVK------------ 1065

  Fly   796 NINLTLEQRNIFTVDPE----YPSFMLFGTCPTIL---IHGNEELINN---CCNIMKPIIKASKE 850
            ::.|.||.::.....|.    .||.::.|..|..:   .||...:...   |...:|.|....|.
Human  1066 HLTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISAGHKY 1130

  Fly   851 MENIYRGGNTIYASERIKNLAEDDRSRVVIEFVMDQLVIE------MQSTERSIAELQIIGARAG 909
            ||.:..                       |.||:.:.::|      ...:..:.:...::|.:..
Human  1131 MEPLQE-----------------------IPFVIPRPILEEGDAFPWTISLHNFSIYTLLGKQVT 1172

  Fly   910 L-TKEPHETNISMSVHGLLLVDAIQSFGPDFELLVASHRHVGMDSLSGSLKHSAIVSPTSPGSPN 973
            | ..||.....:::|....|:    :.|||.........||.::||.        :..::|....
Human  1173 LCLVEPMGCTSTLAVTSQKLL----ATGPDTRHSFVVCLHVDLESLE--------IKCSNPQVQL 1225

  Fly   974 FFDRATSPHMITKAVQ---NIKMGDRSTEFCDDEDSTALISVDIKIVPPNESN---SMQLHTT-- 1030
            |::.....:.:...:|   |:.:...|.|.......|:.:...|...||:.|.   |..:.||
Human  1226 FYELTDIMNKVWNKIQKRGNLNLSPTSPETMAGPVPTSPVRSSIGTAPPDTSTCSPSADIGTTTE 1290

  Fly  1031 --SITFNS----LDIIANQDTIIEILNFAKR-TLLAQNIFPS-----ESPESPKEATEAPVDVVD 1083
              ||....    .|.:..:.|...|...:.| :|..|.:.|.     .:|:...:.||  |.:|.
Human  1291 GDSIQAGEESPFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGTE--VCMVS 1353

  Fly  1084 QVDHKSHNEIFFDFFRLNILLLYT---IKRDKFNVGRKVGTVTLTEAKINASFQSDLSIIGSLGG 1145
            :::..|.:        :::..:||   .|.:.||:..           ..:|...:...:|..||
Human  1354 ELEDLSAS--------IDVQDVYTKVKCKIESFNIDH-----------YRSSLGEECWSLGQCGG 1399

  Fly  1146 IQVIDITSEAFCHPRILSVGRDQILRASD-TNKQTVLSQLSNEIYSNNYNEETKSDESDAISFQS 1209
            :                      .|..:| .|::|:|.:              ...:.|..|..|
Human  1400 V----------------------FLSCTDKLNRRTLLVR--------------PISKQDPFSNCS 1428

  Fly  1210 HWSDKTTC-----TFQMRMASASYTHCPRFLRDVNACITYFKRSLREFATSIGNKATDMAKEFVQ 1269
            .:...||.     |.|.. ...|.|:.....::|...:|  .|:.|.....:.....|.:..|:.
Human  1429 GFFPSTTTKLLDGTHQQH-GFLSLTYTKAVTKNVRHKLT--SRNERRSFHKLSEGLMDGSPHFLH 1490

  Fly  1270 QVRAVEQIGPVYPQRNRQDNWLDIIISSPIIILPISNTSTNVLIANLGKISCSNAVKCDSDEFNE 1334
            ::....|.             .||::..|::     |...::..|.|.|  .....:....:...
Human  1491 EILLSAQA-------------FDIVLYFPLL-----NAIASIFQAKLPK--TQKEKRKSPGQPMR 1535

  Fly  1335 SYTIEIKNTYVYSLN----------IDEGEYSFNVHPAKNKDAIPILHDTAITLQLYAGYSDDND 1389
            ::|:..:|..:..:|          .:|.:.:...:.|..:|.: :|...::.:...|
Human  1536 THTLTSRNLPLIYVNTSVIRIFIPKTEEMQPTVEANQAAKEDTV-VLKIGSVAMAPQA------- 1592

  Fly  1390 EDKQLNRFSIKGSMVE-ALKVSLNR--------KQYELLLESIRYAT-----------NFSNEVL 1434
             |..|.|..::..:.: ||.:.:.|        :||::.|:||...|           :.|..|:
Human  1593 -DNPLGRSVLRKDIYQRALNLGILRDPGSEIEDRQYQIDLQSINIGTAQWHQLKPEKESVSGGVV 1656

  Fly  1435 NESDELDQNGDIEPTANIDAESIISTTIQFSVPVFQINL-----QNEYHNDLINLTFKNFNVKHI 1494
            .|::...||                       |..:.|:     :::....::.....:|:|:..
Human  1657 TETERNSQN-----------------------PALEWNMASSIRRHQERRAILTPVLTDFSVRIT 1698

  Fly  1495 SKGFDKDVEVVLKSVLMEDLKSDLT-----SPFRNMVTSVD----------LEQKIKKNEMTSSS 1544
            .    ....:..|.|..|:|.::..     |...|:.|::|          |.|.|..| ||...
Human  1699 G----APAVIFTKVVSPENLHTEEILVCGHSLEVNITTNLDFFLSVAQVQLLHQLIVAN-MTGLE 1758

  Fly  1545 CPDLPSYCNSLKNRSSSVPSCFYNHMQVKVFGG-----DQKYTSSNKNELGKKKESQTLVIYKSH 1604
                ||      |:::.:..  ....:|.:|.|     ..:|:.:..:.:|.......:|..:.|
Human  1759 ----PS------NKAAEISK--QEQKKVDIFDGGMAETSSRYSGAQDSGIGSDSVKIRIVQIEQH 1811

  Fly  1605 TGRSAQN-GKLEQTSSIQFNCLNLAICVERWYTIFDFFGLVSVDNV----------NEKYPEEMK 1658
            :|.|... .:..:.|||..| ||        :..||.|  ::...:          ::...:|.|
Human  1812 SGASQHRIARPSRQSSIVKN-LN--------FIPFDIF--ITASRISLMTYSCMALSKSKSQEQK 1865

  Fly  1659 LVEKHIDKVCSKLKVSIRSFNFTLIRNESLLSRVNVSNAVFMILQDPYSKIVEGCLGSVSVNDLT 1723
            ..||                     .::|.|:...|.:.|        :|..:.|:.:|:..||.
Human  1866 NNEK---------------------TDKSSLNLPEVDSDV--------AKPNQACISTVTAEDLL 1901

  Fly  1724 KYGNIYKQKFLTSGTEALNFVYKKKL--VDLEALNTLDTDSTLRINMSAVHYIHTKRFSTELHVF 1786
            :              .:::|...||:  :.||:|:. .|.|:.|
Human  1902 R--------------SSISFPSGKKIGVLSLESLHA-STRSSAR--------------------- 1930

  Fly  1787 VKDLLQLQTPVIRKLKKHGS-EQNMRPSKMKLVIQADSPVIVLPSSYNRNEVIIAYLGQFSLKNS 1850
                ..|...::|:..:.|: :..:.|....:|.|   |.::| |.::|.:.:...:....||.
Human  1931 ----QALGITIVRQPGRRGTGDLQLEPFLYFIVSQ---PSLLL-SCHHRKQRVEVSIFDAVLKG- 1986

  Fly  1851 FHFASDNNIISKMSATPSKDEILDVMRIDLVNINLFSGERSSMKAKADQEKDRIIIADMNFLRLG 1915
              .|||...|......|   |.||...:.|..:   .||..|...           ...:|:.|.
Human  1987 --VASDYKCIDPGKTLP---EALDYCTVWLQTV---PGEIDSKSG-----------IPPSFITLQ 2032

  Fly  1916 -QPFFNESCFLHLQLERNLSADAHRVCPDISVQGTFSKLSGI-INIQQYKLIRSF--------LN 1970
             :.|.|....::|.:.:.|.|:.           :|:||..| :.:::.|...|.        ::
Human  2033 IKDFLNGPADVNLDISKPLKANL-----------SFTKLDQINLFLKKIKNAHSLAHSEETSAMS 2086

  Fly  1971 NNIGEQTDDIYMNYHNNSCT-------SIERLSTINLMPKNEVSKIVSIL--ISIRILLEDVSLL 2026
            |.:..:.|.....|:....:       .::::|.     :..:.:.||..  ||::.....:|:.
Human  2087 NTMVNKDDLPVSKYYRGKLSKPKIHGDGVQKISA-----QENMWRAVSCFQKISVQTTQIVISME 2146

  Fly  2027 LALNTSQSAAIEPLACIH---FLKSTLEIDLFSDGSQDIDLISSNILIVDERNESDKSNENVFKN 2088
            ...:||:...:..|:.::   .:|:|.::.....||..:..|:..:|....:..|        :.
Human  2147 TVPHTSKPCLLASLSNLNGSLSVKATQKVPGIILGSSFLLSINDFLLKTSLKERS--------RI 2203

  Fly  2089 ILEPSKKEVRIENSVQVEVHCR------KKATFSKYTIMLNN--MRVF-------ALLSFLDQLK 2138
            ::.|......:|..     .|:      .:.:..|.:|.|..  ::||       .|:...:.|.
Human  2204 LIGPCCATANLEAK-----WCKHSGNPGPEQSIPKISIDLRGGLLQVFWGQEHLNCLVLLHELLN 2263

  Fly  2139 SYLQED--------SPAPVVNNAA--NQIAQKPQIDTSISTEYVVNITDS---------EIIF-- 2182
            .||.|:        .|.|.:::..  ||..:..|....:.|.....:.|:         |::|
Human  2264 GYLNEEGNFEVQVSEPVPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQDAESLKLPGVYEVLFYN 2328

  Fly  2183 -AEECSRL------DSNAIILKSTTVICYKPNSNIVPLSLDINHLEIFSCTLDAEEESALSIIDP 2240
             .|:|..:      :...:.|...|.:.:....:....:.|:..:....|:|:..:|..
Human  2329 ETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQVPCSLEYWDELQ------ 2387

  Fly  2241 FTLIIELRSNCLNILIQKHLNIRLSYVDVKLFSRMARLLPTQTSRPKNVISKADSDLEKAAPLVA 2305
             .:.:..|.  .|:...|...::|.  |:.|.:...:|:              .|||
Human  2388 -KVFVAFRE--FNLSESKVCELQLP--DINLVNDQKKLV--------------SSDL-------- 2425

  Fly  2306 MGFEISDCLYAMQINNWRINDAAIWLSQQKQNTYRNPALEMKTA------------VVDASLISV 2358
                            |||          ..|:.:|.|.:..:|            |...:|.:.
Human  2426 ----------------WRI----------VLNSSQNGADDQSSASESGSQSTCDPLVTPTALAAC 2464

  Fly  2359 FIIDDCMDA-DVPLLEVSLSKFLLNFTFQTQDPNPKETNIRHYSLGNIDTEVSVNYYNRRLSGWE 2422
            ..:|.|... .||.|.||.....|.|            ::.|
Human  2465 TRVDSCFTPWFVPSLCVSFQFAHLEF------------HLCH----------------------- 2494

  Fly  2423 PVAETWESNLNWKYTKGHLDNKKRFEIGISSKQMLKLNVTS------------TFIELFHMVLKN 2475
                             |||     ::|.::.|.|:..|:.            :|.|. ||.|:.
Human  2495 -----------------HLD-----QLGTAAPQYLQPFVSDRNMPSELEYMIVSFREP-HMYLRQ 2536

  Fly  2476 WTN-------------DFNDNGAKNFRQRSPFIPFAL-----------QNLSGTPLLFKPIYAPL 2516
            |.|             |......:|...:|...||::           :.|....::...::..|
Human  2537 WNNGSVCQEIQFLAQADCKLLECRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNL 2601

  Fly  2517 GDLTRSDLQQV-------------ELIKNWYSVQPNETKTFDFSQKSK-----LRHVHSHQLN-- 2561
            |......|...             ||:.:.:.:..:..:|..|.|...     |..:||||.:
Human  2602 GQHVVHSLNTAIQAWQQNKCPEVEELVFSHFVICNDTQETLRFGQVDTDENILLASLHSHQYSWR 2666

  Fly  2562 -------LHQIFVQIHGWTLIG------PISVDKVGMFFRTTKLDSQFLTKSRIVFDISLIGSAQ 2613
                   ||   :.|.||   |      |.|||..|.|.||.:...:   .:.::..:..:...|
Human  2667 SHKSPQLLH---ICIEGW---GNWRWSEPFSVDHAGTFIRTIQYRGR---TASLIIKVQQLNGVQ 2722

  Fly  2614 KLIKVKSSLGVINKLDRNVFLKMTLKGTHSDGLSSISVIKPN-DELSVPLKFIDASLYVAHNTSE 2677
            |.|.:.....:.:.|.:::.||:.   .|..|....:|::.: |.|:...|.   ..|:..|
Human  2723 KQIIICGRQIICSYLSQSIELKVV---QHYIGQDGQAVVREHFDCLTAKQKL---PSYILEN--- 2778

  Fly  2678 SDAYEDTGFSNE--EILWKACGKDDTRQLLAGYDTNKSILYTFVNISREIYHCKEQNLPGHKITL 2740
                      ||  |:..||.|.:|.                    ||::  |.|...|.:.|.:
Human  2779 ----------NELTELCVKAKGDEDW--------------------SRDV--CLESKAPEYSIVI 2811

  Fly  2741 LPPLKINNML---CCDLMFKIHEHATGRINSSESVNIYNVNICQPLNLSITLDNFQLSGQLKIPV 2802
            ..|...::::   |..|..:.:.....|           :.:..||        |.:...|..|:
Human  2812 QVPSSNSSIIYVWCTVLTLEPNSQVQQR-----------MIVFSPL--------FIMRSHLPDPI 2857

  Fly  2803 SHRGVIEPKLKLIDIQKRELHVRVSIQSVPGKGMELYISAPVWIINKTGLPLIYKQEGTSHTAAG 2867
                       :|.::||.|.:. ..|.:||||.|    .|:..|..   .|::      |....
Human  2858 -----------IIHLEKRSLGLS-ETQIIPGKGQE----KPLQNIEP---DLVH------HLTFQ 2897

  Fly  2868 QFEEHETARQVAPLMFSFSDQEGS---PALVLR--LGKAYGSNNMWCKSFSTHKDLADRDLRAEN 2927
            ..||::.:....|:..|...|..:   |...:.  |.:.||........:..:|..:||:.:...
Human  2898 AREEYDPSDCAVPISTSLIKQIATKVHPGGTVNQILDEFYGPEKSLQPIWPYNKKDSDRNEQLSQ 2962

  Fly  2928 TKGSYAIGISVRRGRGLYACTTFVTLSPRFHLHNRSGYKLEFMQLCDIVNYDRPDPRKIISAPVD 2992
            ......:.:|:.:.   |..|..:.|.|...|.|.|.:.|...:...||.  :....|||..|
Human  2963 WDSPMRVKLSIWKP---YVRTLLIELLPWALLINESKWDLWLFEGEKIVL--QVPAGKIIIPP-- 3020

  Fly  2993 CNF--AF----HW--------------------PNW-----------DQEQIICVRI-----PEI 3015
             ||  ||    :|                    |.|           |:|..:...|     |..
Human  3021 -NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEIRLGAFPGH 3084

  Fly  3016 ECCCW-------SKGIPIKDVQSLYINVRNEWGEMFFL-RLEI-----------ISKDATFILLF 3061
            :..|.       .:||.|..::.....:.|...::|:. :|.:           :...|||.:
Human  3085 QKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVCNPHSGKEYFRVPDSATFSI-- 3147

  Fly  3062 TDARTLPPPIRIDNC---SEVVINFSQLRSKPVWITPVRPQSSLSYVMDDPLGQQILL--MEAPG 3121
                          |   .:..:..|.|   |.|  .:.|..|.|.:....|.:||:|  ..|||
Human  3148 --------------CPGGEQPAMKSSSL---PCW--DLMPDISQSVLDASLLQKQIMLGFSPAPG 3193

  Fly  3122 GNMI-----------EFPINNKNNIKKTLTYTNFIYIAFQGTFERSNEEENTHRQLVLGVRGKKV 3175
            .:..           |||   :.::...|                .|..||       |...:.:
Human  3194 ADSSQCWSLPAIVRPEFP---RQSVAVPL----------------GNFREN-------GFCTRAI 3232

  Fly  3176 VIVEKNSGDRSQLWLMNSNGQLEHEGSTPPIQTNDANAVRLVLDLEKAPNPMEFTNLVVRTPNKQ 3240
            |:..:                 ||.|.|             .|.|.:.|:|
Human  3233 VLTYQ-----------------EHLGVT-------------YLTLSEDPSP-------------- 3253

  Fly  3241 RVTTQTWRFENGRLMCHANMCVQSRFGESGLK--PNYEAVVGRTENRASSSKQIPIGQHIVAQKL 3303
                        |::.| |.|......:..:|  |.:|..          .|:||
Human  3254 ------------RVIIH-NRCPVKMLIKENIKDIPKFEVY----------CKKIP---------- 3285

  Fly  3304 RPGSGQLELSTKMDGPISTIEICDIKIKQNSVFLTPDLL------WMHASLNNRQITDKGKVSFV 3362
                .:..:..::...||:...|..|....|:.|..:.|      |..|...|.|.|   :|.|:
Human  3286 ----SECSIHHELYHQISSYPDCKTKDLLPSLLLRVEPLDEVTTEWSDAIDINSQGT---QVVFL 3343

  Fly  3363 HEY-LINVELVKGIGISIIA---------------RKPCEEI----MFIS---------LDH--I 3396
            ..: .:.|::|...|...|.               |.| |:|    |||:         |.|  .
Human  3344 TGFGYVYVDVVHQCGTVFITVAPEGKAGPILTNTNRAP-EKIVTFKMFITQLSLAVFDDLTHHKA 3407

  Fly  3397 NCDIVQSALEN-------------------------SLDLNIAYIQIDNQLLDAVSPIALHTQTS 3436
            :.::::..|:|                         .:::....:|:||||.:          .|
Human  3408 SAELLRLTLDNIFLCVAPGAGPLPGEEPVAALFELYCVEICCGDLQLDNQLYN----------KS 3462

  Fly  3437 N--------DLEETQNAVVLKLKMLPSPNKNAIIFKYLTLDLKPSTASLEEKLILKVASFLGYGK 3493
            |        ..|:.:.....|::.|...||....:|              ||..:|:...|..||
Human  3463 NFHFAVLVCQGEKAEPIQCSKMQSLLISNKELEEYK--------------EKCFIKLCITLNEGK 3513

  Fly  3494 -----INRQNLSVQYQFENTDDKPFLQDMKRYYFE--------NLSIGATQVRLSAFTSSKLPVE 3545
                 ||      ::.||....:.:::|...||.:        |..:......||. ....||::
Human  3514 SILCDIN------EFSFELKPARLYVEDTFVYYIKTLFDTYLPNSRLAGHSTHLSG-GKQVLPMQ 3571

  Fly  3546 LHETKKALGLTLIKFEDALIE-----------LDRYSDKLH-------FETMDVYR------KEL 3586
            :.:..:|| :..:|....:|:           |..|....|       ||...::.      ..|
Human  3572 VTQHARAL-VNPVKLRKLVIQPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFTTARQLVHAL 3635

  Fly  3587 KKHYINQVKWHAAAILGSVDFLGNPLGFANDLSEGVSG---LIFEGSVK--------------SL 3634
            ..||.....:.|..::||:|.||:|......:..||:.   |.:||..:              |.
Human  3636 AMHYAAGALFRAGWVVGSLDILGSPASLVRSIGNGVADFFRLPYEGLTRGPGAFVSGVSRGTTSF 3700

  Fly  3635 VKNVTHGISNSTAKLTETLSDSLGKVVLD-DHDN---ETRQRILELQSNTSGGHLAAGLKGLGFG 3695
            ||:::.|...|...|..:|:.::.::.|| :|.|   |.|:::.|    :.|..|..||..||..
Human  3701 VKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQLPE----SLGEGLRQGLSRLGIS 3761

  Fly  3696 LLGGVTSIV-------RHTYDGATSDG--VPGFLSGLGKGLVGTVTKPIIGVLDLASETASAVRE 3751
            |||.:..||       :.|.:...|.|  ..|.:||:|||::|..||||.|..:|.|:|...:..
Human  3762 LLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGIMGVFTKPIGGAAELVSQTGYGILH 3826

  Fly  3752 TSRDSHRNAPERKRLPRCVTG--APGGLLP-LYSNRQSKGQQYLYLINQKNFSEKIISYEPNLWS 3813
            .:..|  ..|:::..|..:..  ||...:. ::...||.|:..:::      :..::...   .|
Human  3827 GAGLS--QLPKQRHQPSDLHADQAPNSHVKYVWKMLQSLGRPEVHM------ALDVVLVR---GS 3880

  Fly  3814 DKEARLRLLVSTEYVRIFSLSD-----ANPTIMFEC 3844
            .:|....||:::|.:.:.|:|:     |.|....:|
Human  3881 GQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDC 3916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps13D	NP_729825.2	Chorein_N	4..112	CDD:315323	26/120 (22%)
		VPS13	147..368	CDD:318996	41/301 (14%)
		VPS13_mid_rpt	<656..837	CDD:318998	34/203 (17%)
		VPS13	<2039..>2694	CDD:330393	131/785 (17%)
		SHR-BD	2836..3113	CDD:310922	62/345 (18%)
		VPS13	<3346..3802	CDD:330393	127/589 (22%)
VPS13B	NP_060360.3	Chorein_N	3..94	CDD:289396	23/90 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..134		9/50 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1247..1314		14/66 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1860..1880		6/40 (15%)
		SHR-BD	<2632..>2712	CDD:284143	22/88 (25%)
		VPS13_C	3585..3731	CDD:293514	30/145 (21%)
		ATG_C	3733..3839	CDD:286423	35/111 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030