DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10984 and Ankrd11

DIOPT Version :9

Sequence 1:	NP_729823.2	Gene:	CG10984 / 39446	FlyBaseID:	FBgn0036305	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_001074848.2	Gene:	Ankrd11 / 77087	MGIID:	1924337	Length:	2643	Species:	Mus musculus

Alignment Length:	554	Identity:	154/554 - (27%)
Similarity:	251/554 - (45%)	Gaps:	89/554 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 SEHGKDVKGASLKLTSRVEKSSKLAATKGSPSGNKSSASNAEKEPAETSKNV--DIENETECSDD 209
            ::...||:..:.| .|.|..:.......|...|....|..||:.||...:..  .:..|.|.|::
Mouse  2135 AKDASDVEAEAAK-ASPVPPAESPPGPTGVLGGGDVPAPAAEEPPAPPPQEASPQLSTEPEPSEE 2198

  Fly   210 YKSNDSLYNGGLKVPPLKIVIPQQNCSIDTEGNVLRTGKVTASRNAALPYVVSSNSDSIDTVITN 274
                          |.|.:|:   ..:::||        |.|..:|.    .:|.|:|:......
Mouse  2199 --------------PKLDVVL---EATVETE--------VLADDSAP----EASISNSVPAPSPP 2234

  Fly   275 QSISP------HESPQKSNSICSTALDDKNIKLFNDEKNLRVLRSSHRTG-----VTSVERSSNN 328
            |...|      .|:...|.:.|...          |......|..:|.:.     |.:.|....|
Mouse  2235 QQQPPGGGDEEAETEDPSATPCCAP----------DGPTTDGLAQAHNSAEASCVVAAAEGPPGN 2289

  Fly   329 -----SSPQMQSSSPSPASSNHANDPADVKLSYSNMTSSPIPQGHQFDQEAITNVPSPSTSSTSS 388
                 :.|:.:.:|..|.:......|..:..:.:.|.:|...||    ..|....|.|:.:|.:.
Mouse  2290 VQAEATDPEPKPTSEVPKAPKVEEVPQRMTRNRAQMLASQSKQG----IPAAEKDPMPTPASRAK 2350

  Fly   389 SKDINPSNVEL-HPRKRKIR------PKNTDDSSKNSN--------AADSGVNSEESHPHDHPFT 438
            .:.....:.:. |||||:.:      .:..:.|::.:.        |....:..:...|:....:
Mouse  2351 GRASEEEDAQAQHPRKRRFQRSSQQLQQQLNTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRS 2415

  Fly   439 NGFQMFLSIRRQIEKKWKSLYPVKPRPPQGYNEYLLTKKSYLL--RRNATISVPDI--PRTVPQA 499
            |.:..:|.||::||:|.|.|..:.|:.||.|.||:....||||  :..:.:.:|.|  |.::.:.
Mouse  2416 NPYFEYLQIRKKIEEKRKILCCITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEP 2480

  Fly   500 MERIYQDQEKARRDLIEAHTVEREKLCMNVEQEIIRVHSKAARSISGQPAPYSVCTYLKDDEVYN 564
            ::.:::.||..|..|...|::|||||.::.||||:|||.:|||:|:.|..|:|.||.|.|.||||
Mouse  2481 LKELFKQQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYN 2545

  Fly   565 MITPEQDEKEKSARCRFNGRLLLSWLQDVDDKWEKIKESMVLRHHNEAESLHAVQVMDWNIFAK- 628
            |....|.::.||.|.|||.|..:|||||||||::::|..:::|..:||.:|:|||.|:|.:.|:
Mouse  2546 MPLESQGDENKSVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQLKAQE 2610

  Fly   629 -----RNRLCDNPIEVNLEHVPIVSVGDDFDTLP 657
                 ...||.|  ||...:||:|.|.|||..||
Mouse  2611 LDPAGHKSLCVN--EVPSFYVPMVDVNDDFVLLP 2642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10984	NP_729823.2	None
Ankrd11	NP_001074848.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..170
		ANK repeat	167..198	CDD:293786
		ANK 1. /evidence=ECO:0000255	167..196
		Ank_2	172..264	CDD:372319
		ANK repeat	200..231	CDD:293786
		ANK 2. /evidence=ECO:0000255	200..229
		ANK 3. /evidence=ECO:0000255	233..262
		ANK repeat	233..261	CDD:293786
		ANK 4. /evidence=ECO:0000255	266..292
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..365
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..504
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..651
		PTZ00121	<666..1543	CDD:173412
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..805
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..962
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	977..1037
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1051..1074
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1114..1388
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1420..1711
		PHA03247	<1641..2160	CDD:223021	5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1863..1900
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1981..2027
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2111..2386		55/294 (19%)
		PRK07003	<2143..>2367	CDD:235906	50/267 (19%)
		Important for protein degradation. /evidence=ECO:0000250\|UniProtKB:Q6UB99	2349..2643		105/296 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2649
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3571
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44339
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.990