DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10984 and Ankrd11

DIOPT Version :9

Sequence 1:	NP_729823.2	Gene:	CG10984 / 39446	FlyBaseID:	FBgn0036305	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_001360938.1	Gene:	Ankrd11 / 365023	RGDID:	1306679	Length:	2639	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	161/575 - (28%)
Similarity:	259/575 - (45%)	Gaps:	88/575 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 DSEHGKDVKGASLKLTSRVEKSSKLAATKGSPSGN--------------KSSASNAEKEPAETSK 196
            ||.|       |:...|:||..|...|.. ||..:              ...||:.|.|.||.|.
  Rat  2089 DSSH-------SISALSQVEPVSWHEAFT-SPEDDLDLGPFSLPELPLQAKDASDVEAETAEASP 2145

  Fly   197 NVDIENETECSDDYKSNDSLYNGG------LKVPPLKIVIPQQNCS--IDTEGNVLRTGKVTASR 253
            ...:|:.       .....:.:||      .:.||..   |.|..|  :.||.......|:....
  Rat  2146 APPVESP-------PGPTGVLSGGDVPASTTEEPPAP---PPQEASPQLSTEPEPSEETKLDVVL 2200

  Fly   254 NAALPYVVSSNSDSIDTVITNQSISPHESPQKSNSIC-----STALDDKNIK--LFNDEKNLRVL 311
            .||....|.::..:.:..|:|  :.|..||.:.....     .|..:|.:..  ...|......|
  Rat  2201 EAAAETEVLADDSAPEASISN--LVPAPSPPEQQRPAGGGDEETEAEDPSAAPCCAPDGPTTDGL 2263

  Fly   312 RSSHRTG-----VTSVERSSNNSSPQMQSSSPSPASS-----NHANDPADVKLSYSNMTSSPIPQ 366
            ..:..:.     |.:||....|..|:.....|.|.|.     .....|..:..:.:.|.:|...|
  Rat  2264 AQAPNSAEAACVVAAVEGPPGNIQPEATDPEPKPTSEAPKAPKVEEVPQRMTRNRAQMLASQSKQ 2328

  Fly   367 GHQFDQEAITNVPSPSTSSTSSSKDINPSNVELHPRKRKIR------PKNTDDSSKNSN------ 419
            |....::  .::|:|::.:...:.:...:..: |||||:.:      .:..:.|::.:.
  Rat  2329 GIPATEK--DSMPAPASRAKGRAPEEEDAQAQ-HPRKRRFQRSGQQLQQQLNTSTQQTREVIQQT 2390

  Fly   420 --AADSGVNSEESHPHDHPFTNGFQMFLSIRRQIEKKWKSLYPVKPRPPQGYNEYLLTKKSYLL- 481
              |....:..:...|:....:|.:..:|.||::||:|.|.|..:.|:.||.|.||:....||||
  Rat  2391 LAAIVDAIKLDAIEPYHSDRSNPYFEYLQIRKKIEEKRKILCCITPQAPQCYAEYVTYTGSYLLD 2455

  Fly   482 -RRNATISVPDI--PRTVPQAMERIYQDQEKARRDLIEAHTVEREKLCMNVEQEIIRVHSKAARS 543
             :..:.:.:|.|  |.::.:.::.:::.||..|..|...|::|||||.::.||||:|||.:|||:
  Rat  2456 GKPLSKLHIPVIAPPPSLAEPLKELFKQQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAART 2520

  Fly   544 ISGQPAPYSVCTYLKDDEVYNMITPEQDEKEKSARCRFNGRLLLSWLQDVDDKWEKIKESMVLRH 608
            |:.|..|:|.||.|.|.|||||....|.::.||.|.|||.|..:|||||||||::::|..:::|.
  Rat  2521 IANQAVPFSACTMLLDSEVYNMPLESQGDENKSVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQ 2585

  Fly   609 HNEAESLHAVQVMDWNIFAK------RNRLCDNPIEVNLEHVPIVSVGDDFDTLP 657
            .:||.:|:|||.|:|.:.|:      ...||.|  ||...:||:|.|.|||..||
  Rat  2586 QHEAAALNAVQRMEWQLKAQELDPAGHKSLCVN--EVPSFYVPMVDVNDDFVLLP 2638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10984	NP_729823.2	None
Ankrd11	NP_001360938.1	ANK repeat	167..198	CDD:293786
		Ank_2	172..264	CDD:372319
		ANK repeat	200..231	CDD:293786
		ANK repeat	233..261	CDD:293786
		PTZ00121	<732..1634	CDD:173412
		PHA03247	<1602..1947	CDD:223021
		PHA03247	<1858..2369	CDD:223021	61/302 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	206	1.000	Domainoid score	I2808
eggNOG	1	0.900	-	-		E1_2CMIW
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3640
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46437
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.860