DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10984 and ankrd11

DIOPT Version :9

Sequence 1:	NP_729823.2	Gene:	CG10984 / 39446	FlyBaseID:	FBgn0036305	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	XP_005166634.1	Gene:	ankrd11 / 327352	ZFINID:	ZDB-GENE-030131-3932	Length:	2820	Species:	Danio rerio

Alignment Length:	702	Identity:	185/702 - (26%)
Similarity:	292/702 - (41%)	Gaps:	176/702 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PRSNSNTPMSERQQM-----ALLIQMTANSSTV-------QSQSLELLLVGLNFNLHHSSRTTLK 70
            |.|....|..|::..     |..|....:|.|:       .|:::|::.|.|         ::|.
Zfish  2232 PFSIPELPFQEKEMQDPDITAPEIAENKHSPTLTRPPVIETSENVEMINVDL---------SSLS 2287

  Fly    71 KNECKKGDAETDEGSLN------------------EKQ---EVLDTKDKSSAEESSNDGKSSDTN 114
            |..|.......||.|.:                  |.|   :||..|:..|.|....:|  .|.|
Zfish  2288 KAPCSPTVVPHDESSQDLVPPVSKDDYTPQCELEPEPQNIPDVLPIKETISEERGGFEG--MDIN 2350

  Fly   115 HQGTSAAKRCYSDIEEDYEESGEDVKKKKRKDSEHGKDVKGASLKLTSRVEKSSKLAATKGSPSG 179
            :....|.:      |:|:|         .||     |::...::..:..|:.......||
Zfish  2351 NDNLLATE------EQDHE---------YRK-----KEINPDAMMPSVMVQYLELPVTTK----- 2390

  Fly   180 NKSSASNAEKEPAETSKNVDIENETECSDDYKSNDSLYNGGLKVPPLKIVIPQQNCSIDTEGNVL 244
                       |....:|..:.....||                |.|.:.||.  .|:.|..:|.
Zfish  2391 -----------PHLLGQNPVVALGPSCS----------------PHLTVHIPA--VSMPTSTHVS 2426

  Fly   245 RTGKVTASRNAALPYVVSSNSDSIDTVITNQSISPHESPQKSNSICSTALDDKNIKLFNDEKNLR 309
            .|.:.||..:..:|  ||                  |:|:|...|.......|...|.|..|...
Zfish  2427 ETLETTAKLSVTIP--VS------------------EAPKKIEEIPQRITRKKAQMLANQNKQSA 2471

  Fly   310 VLRSSHRTGVTSVERSSNNSSPQMQSSSPSPASSNHANDPADVKLSYSNMTSSPIPQGHQFDQEA 374
            .|.||..|                .|.|.||.:::.......|:.....::||.:.
Zfish  2472 TLSSSSIT----------------HSVSSSPITTSVTTSCVTVEKEKETISSSNVQ--------- 2511

  Fly   375 ITNVPS-PSTSSTSSSKDI-NPSNVELHPRKRKIRPKN---------TDDSSKNSN--------A 420
             |:.|| |:..:.:..:.| :..|...||||||. ||:         .:.:.|.:.        .
Zfish  2512 -TSAPSAPALITKTKGRPIEDDDNQSQHPRKRKF-PKSGQQQVQVQLVNTAMKQTREMIQQTLAV 2574

  Fly   421 ADSGVNSEESHPHDHPFTNGFQMFLSIRRQIEKKWKSLYPVKPRPPQGYNEYLLTKKSYLL--RR 483
            ..:.:..:|..|:....:|.:..:|.||::||:|.|.|..:.|:.||.|.:|:....||||  :.
Zfish  2575 IVNAIKLDEIEPYHSDRSNPYFEYLQIRKKIEEKRKILCYITPQAPQCYADYVTYTGSYLLDGKP 2639

  Fly   484 NATISVPDI--PRTVPQAMERIYQDQEKARRDLIEAHTVEREKLCMNVEQEIIRVHSKAARSISG 546
            .:.:.:|.|  |.::.:.::.:::.||..|..|...|::|||||.::.|||::|||.:|||:|:.
Zfish  2640 LSKLHIPVIAPPPSLSEPLKELFRQQEAVRGKLRLQHSIEREKLIVSCEQEVLRVHCRAARTIAN 2704

  Fly   547 QPAPYSVCTYLKDDEVYNMITPEQDEKEKSARCRFNGRLLLSWLQDVDDKWEKIKESMVLRHHNE 611
            |..|:|.||.|.|.|||||.:..|.::.||.|.|||.|..:||:||||||::::|..:::|..:|
Zfish  2705 QAVPFSACTMLLDSEVYNMPSESQGDENKSVRDRFNARQFISWIQDVDDKYDRMKTCLLMRQQHE 2769

  Fly   612 AESLHAVQVMDWNIF------AKRNRLCDNPIEVNLEHVPIVSVGDDFDTLP 657
            |.:|:|||.|:|.:.      |....||.|  ||...:||:|.|.|||..||
Zfish  2770 AAALNAVQRMEWQLKVQELDPAGHKSLCVN--EVPSFYVPMVDVNDDFVLLP 2819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG10984	NP_729823.2	None
ankrd11	XP_005166634.1	ANK	162..284	CDD:238125
		ANK repeat	167..198	CDD:293786
		Ank_2	172..264	CDD:289560
		ANK repeat	200..231	CDD:293786
		ANK repeat	233..258	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24769
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.900