DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10984 and ANKRD11

DIOPT Version :9

Sequence 1:	NP_729823.2	Gene:	CG10984 / 39446	FlyBaseID:	FBgn0036305	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_001243111.1	Gene:	ANKRD11 / 29123	HGNCID:	21316	Length:	2663	Species:	Homo sapiens

Alignment Length:	540	Identity:	145/540 - (26%)
Similarity:	241/540 - (44%)	Gaps:	103/540 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 GSP---SGNKSSASNAEKEPA----ETSKNVDIENETECSDDYKSNDSLYNGGLKVPPLKIVIPQ 232
            |:|   :|...|...||:.||    :.|..:..|.|.|.|.:              |.|.:.:
Human  2169 GAPGVINGGDVSTVVAEEPPALPPDQASTRLPAELEPEPSGE--------------PKLDVAL-- 2217

  Fly   233 QNCSIDTEGNVLRTGKVTASRNAALPYVVSSNSDSIDTVITNQSISPHESPQKSN---------- 287
             ..:::.|       .|...|....|          |:.:....:.|.:.|..|.
Human  2218 -EAAVEAE-------TVPEERARGDP----------DSSVEPAPVPPEQRPLGSGDQGAEAEGPP 2264

  Fly   288 --SICSTALDDKNIKLFNDEKNLRVLRSSHRTGVTSVERSSNNSSP--------QMQSSSPSPAS 342
              |:|:......|        .:...:::...|......:|..::|        |.:::.|.|.:
Human  2265 AASLCAPDGPAPN--------TVAQAQAADGAGPEDDTEASRAAAPAEGPPGGIQPEAAEPKPTA 2321

  Fly   343 S-----NHANDPADVKLSYSNMTSSPIPQGHQFDQEAITNVPSPSTSSTSSSKDINPSNVELHPR 402
            .     .....|..:..:.:.|.::...||....::.....|:|.|.:.:...:.:.:..: |||
Human  2322 EAPKAPRVEEIPQRMTRNRAQMLANQSKQGPPPSEKECAPTPAPVTRAKARGSEDDDAQAQ-HPR 2385

  Fly   403 KRKIRPKNTDDSSKNSN---------------AADSGVNSEESHPHDHPFTNGFQMFLSIRRQIE 452
            ||:.: ::|....:..|               |....:..:...|:.....|.:..:|.||::||
Human  2386 KRRFQ-RSTQQLQQQLNTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRANPYFEYLQIRKKIE 2449

  Fly   453 KKWKSLYPVKPRPPQGYNEYLLTKKSYLL--RRNATISVPDI--PRTVPQAMERIYQDQEKARRD 513
            :|.|.|..:.|:.||.|.||:....||||  :..:.:.:|.|  |.::.:.::.:::.||..|..
Human  2450 EKRKILCCITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFRQQEAVRGK 2514

  Fly   514 LIEAHTVEREKLCMNVEQEIIRVHSKAARSISGQPAPYSVCTYLKDDEVYNMITPEQDEKEKSAR 578
            |...|::|||||.::.||||:|||.:|||:|:.|..|:|.||.|.|.|||||....|.::.||.|
Human  2515 LRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNMPLESQGDENKSVR 2579

  Fly   579 CRFNGRLLLSWLQDVDDKWEKIKESMVLRHHNEAESLHAVQVMDWNIF------AKRNRLCDNPI 637
            .|||.|..:|||||||||::::|..:::|..:||.:|:|||.|:|.:.      |....||.|
Human  2580 DRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQLKVQELDPAGHKSLCVN-- 2642

  Fly   638 EVNLEHVPIVSVGDDFDTLP 657
            ||...:||:|.|.|||..||
Human  2643 EVPSFYVPMVDVNDDFVLLP 2662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10984	NP_729823.2	None
ANKRD11	NP_001243111.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..169
		ANK	162..284	CDD:238125
		ANK repeat	167..198	CDD:293786
		ANK 1	167..196
		Ank_2	172..264	CDD:289560
		ANK repeat	200..231	CDD:293786
		ANK 2	200..229
		ANK 3	233..262
		ANK repeat	233..261	CDD:293786
		ANK 4	266..292
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..380
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..647
		AAA_23	<656..768	CDD:290211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..783
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	881..1043
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1059..1393
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1424..1710
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1814..1836
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1988..2019
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2131..2406		46/280 (16%)
		Important for protein degradation. /evidence=ECO:0000269\|PubMed:25413698	2369..2663		106/298 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	233	1.000	Domainoid score	I2405
eggNOG	1	0.900	-	-		E1_2CMIW
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3428
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42285
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.850