DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10984 and ANKRD12

DIOPT Version :9

Sequence 1:	NP_729823.2	Gene:	CG10984 / 39446	FlyBaseID:	FBgn0036305	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_056023.3	Gene:	ANKRD12 / 23253	HGNCID:	29135	Length:	2062	Species:	Homo sapiens

Alignment Length:	786	Identity:	197/786 - (25%)
Similarity:	321/786 - (40%)	Gaps:	198/786 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PPPRPKGIG-------------FNTGATQP--RSNSNTPMSERQQMALLIQMTANSSTVQSQSLE 51
            |.|:|:...             .::.||.|  .|||....::|.    ||:.||..:||....:.
Human  1344 PSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSKYVSADRN----LIKNTAPVNTVMDSPVH 1404

  Fly    52 L-------LLVGLNFNLHHSSRTTLKKNE--CKKGDAETDEGSL----NEKQEVL-DTKDKSSAE 102
            |       ::...::.:......||...:  |...:....|.||    |.:.:|| :..|..|..
Human  1405 LEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLR 1469

  Fly   103 ESSNDGKSSDTN-------HQGTSAAKRCYSDIEEDYEESGEDVKKKKRKDSEHGKDVKGASLKL 160
            ::...|.|...:       .|..|...:..||.|.
Human  1470 QTELPGNSCAQDPASFMPPQQPCSFPSQSLSDAES------------------------------ 1504

  Fly   161 TSRVEKSSKLAATKGSPSG-----NK----SSASNAEKEPAETSKNVDIENETECSDDYKS--ND 214
               :.|...|:.......|     |.    |||.:.:.|..:.::|..:..:.:.:|.:..  :|
Human  1505 ---ISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSD 1566

  Fly   215 SL-------YNGGLKVPPLKIVIPQQNCSIDTEGNVLRTGKVTASRNAALPYVVSSNSDSIDTVI 272
            |.       :.....:|    |:|.:.   |..|:...|...|....:.|.| .||:...::...
Human  1567 STIQEASPNFEKAYTLP----VLPSEK---DFNGSDASTQLNTHYAFSKLTY-KSSSGHEVENST 1623

  Fly   273 TNQSISPHESPQKSNSICSTAL-----------------------------DDKNIKLFNDEKNL 308
            |:..:..||...|..|:..|.|                             .:|.:....||::.
Human  1624 TDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQ 1688

  Fly   309 RVLRSS-------------HRTG-VTSVERSSNNSSPQMQSSSPSPASSNHANDPADVKLSYSNM 359
            :.:.||             |:.| :..||...|....:.::..|...:.|.||..|:
Human  1689 QSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMAN-------- 1745

  Fly   360 TSSPIPQGHQFDQEAITNVPSPSTSSTSS-------SKDINPSNVELHPRKRKI----RPKNTDD 413
                  |..|.  .|...:.|...|.:||       ::|.:|.  ..||||||:    :|.....
Human  1746 ------QSKQI--LASCTLLSEKDSESSSPRGRIRLTEDDDPQ--IHHPRKRKVSRVPQPVQVSP 1800

  Fly   414 S-------SKNSNAA--DSGVNSEESHPHDHPFTNGFQMFLSIRRQIEKKWKSLYPVKPRPPQGY 469
            |       ::.|.||  || :..:|..|:.....|.:..:|.||::||:|.|.|..|.|:.||.|
Human  1801 SLLQAKEKTQQSLAAIVDS-LKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYY 1864

  Fly   470 NEYLLTKKSYLLRRN--ATISVPDI--PRTVPQAMERIYQDQEKARRDLIEAHTVEREKLCMNVE 530
            :||:....||||..|  :.|.:|.|  |.::...::.:::.||..|..|...|::|||||.::.|
Human  1865 DEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNE 1929

  Fly   531 QEIIRVHSKAARSISGQPAPYSVCTYLKDDEVYNM-ITPEQDEKEKSARCRFNGRLLLSWLQDVD 594
            ||::|||.:|||:::.|..|:|.||.|.|.||||: :..:.|:.:.|.|.|||.|..:|||||||
Human  1930 QEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVD 1994

  Fly   595 DKWEKIKESMVLRHHNEAESLHAVQVMDWNIFAKRNRLCDNP--------IEVNLEHVPIVSVGD 651
            ||::|:|..:::|..:||.:|:|||.::|.:  |...|  :|        .|:...:||:|.|.|
Human  1995 DKFDKLKTCLLMRQQHEAAALNAVQRLEWQL--KLQEL--DPATYKSISIYEIQEFYVPLVDVND 2055

  Fly   652 DFDTLP 657
            ||:..|
Human  2056 DFELTP 2061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10984	NP_729823.2	None
ANKRD12	NP_056023.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..188
		ANK	179..291	CDD:238125
		ANK repeat	184..215	CDD:293786
		ANK 1	184..213
		ANK repeat	217..248	CDD:293786
		ANK 2	217..246
		ANK 3	250..280
		ANK repeat	250..278	CDD:293786
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..338
		SMC_N	<363..983	CDD:330553
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..501
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..577
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..683
		Neuromodulin_N	<720..1165	CDD:331332
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..788
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	812..1073
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1097..1227
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1328..1350		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1721..1744		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1756..1795		12/40 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	233	1.000	Domainoid score	I2405
eggNOG	1	0.900	-	-		E1_2CMIW
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3428
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006031
OrthoInspector	1	1.000	-	-		otm42285
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5253
SonicParanoid	1	1.000	-	-		X4941
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.850