DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10984 and Ankrd12

DIOPT Version :9

Sequence 1:	NP_729823.2	Gene:	CG10984 / 39446	FlyBaseID:	FBgn0036305	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	XP_006523456.1	Gene:	Ankrd12 / 106585	MGIID:	1914357	Length:	2067	Species:	Mus musculus

Alignment Length:	771	Identity:	198/771 - (25%)
Similarity:	312/771 - (40%)	Gaps:	211/771 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TANSS-------TVQSQSLELLLVGLNFNLHHSSRTTLKKNECKKGDAETDEGSLNEKQEVLDTK 96
            :||||       .::|.:|...|:..:.:|..|::..:..:  |..:...|      |.|.|.|.
Mouse  1355 SANSSYISSDVNVIKSATLVGTLIDSSMHLEPSNQVGVIPS--KSWETPVD------KLESLSTN 1411

  Fly    97 DKSSAEESSNDGKSSDTNHQGTSAAKRCYSDIEEDYEESGEDVKKKKRKDSEHGKDVKGAS---- 157
            |....:.:.:|..||         |:..|:...:...|...|..      ..|..::.|.|
Mouse  1412 DFICPDSNISDQDSS---------AQSFYNSENKMLREQNTDCL------PPHQPELPGNSCAQD 1461

  Fly   158 -----------------LKLTSRVEKSSKLAATKGSPSG--NKSSASNAEKEPAETSKNV--DIE 201
                             |.....|.|...|:.......|  .:.||:.......::..|.  |:|
Mouse  1462 PASFLSSPQPCSFSNQPLAGADSVPKPVSLSYVVSQEPGVLQQKSAAQMASSVLDSDNNFPEDVE 1526

  Fly   202 NETECSDDYKSNDSL--YNGGL---KVPPLK-----IVIPQQNCSIDTEGNVLRTGKVTASRN-- 254
            |....:|..|:|..|  |:...   .:|..:     :|:|.:.     :.|    |..||..|
Mouse  1527 NTFVLADIQKTNSFLPAYSESTVQEALPSFEKANTLLVLPSEK-----DFN----GSDTAQPNTH 1582

  Fly   255 ---AALPYVVSSNSDSIDTVITNQSISPHESPQKSNSI-------CSTALDDKNIKL----FNDE 305
               :.|.| .||||..|:....:..|..||...|..|:       |.:.|.:.|..|    .|::
Mouse  1583 YAFSKLTY-KSSNSQEIEKGPDDTQIISHEKENKLQSLVLTQLSKCDSDLYEMNAGLPKGNLNEQ 1646

  Fly   306 KNLRVLRSSHRTGVTSVERSSNNSSPQMQSSSPSPASSNHANDPADVKLSYSNMTSSPIPQGHQF 370
            .|       .:.|:.|.:.|.:....:.|.|:.| :..||:...|.             |:.|::
Mouse  1647 DN-------PKHGLDSEKYSLSTEDEESQQSTLS-SVENHSQQSAQ-------------PEMHKY 1690

  Fly   371 DQ----EAITNVPSPSTSS--------TSSSKDINPSNVEL------------------------ 399
            ||    |...|.....|.:        ..:|..:|||...|
Mouse  1691 DQLSKVELEENAEDDKTENQTPQRVTRNKASTVVNPSKPMLAGCALVAEKDNESSPRGRIRLTEE 1755

  Fly   400 ------HPRKRKI----RPKNTDDS-------SKNSNAA--DSGVNSEESHPHDHPFTNGFQMFL 445
                  ||||||:    :|.....|       ::.|.||  || :..:|..|:.....|.:..:|
Mouse  1756 DDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDS-LKLDEIEPYSSERANPYFEYL 1819

  Fly   446 SIRRQIEKKWKSLYPVKPRPPQGYNEYLLTKKSYLLRRN---------------------ATISV 489
            .||::||:|.|.|..|.|:.||.|:||:....||||..|                     :|:..
Mouse  1820 HIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTRRERISVDFLSSSTLRS 1884

  Fly   490 PDIP----RTVP-----QAMERIYQDQEKARRDLIEAHTVEREKLCMNVEQEIIRVHSKAARSIS 545
            |.:|    |..|     ..::.:::.||..|..|...|::|||||.::.|||::|||.:|||:::
Mouse  1885 PSLPCLCQRITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLA 1949

  Fly   546 GQPAPYSVCTYLKDDEVYNM-ITPEQDEKEKSARCRFNGRLLLSWLQDVDDKWEKIKESMVLRHH 609
            .|..|:|.||.|.|.||||: :..:.|:.:.|.|.|||.|..:|||||||||::|:|..:::|..
Mouse  1950 NQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQ 2014

  Fly   610 NEAESLHAVQVMDWNIFAKRNRLCDNP--------IEVNLEHVPIVSVGDDFDTLP 657
            :||.:|:|||.::|.:  |...|  :|        .|:...:||:|.|.|||:..|
Mouse  2015 HEAAALNAVQRLEWQL--KLQEL--DPATYKSLSIYEIQEFYVPLVDVNDDFELTP 2066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG10984	NP_729823.2	None
Ankrd12	XP_006523456.1	ANK repeat	184..215	CDD:293786
		Ank_2	189..277	CDD:403870
		ANK repeat	217..248	CDD:293786
		ANK repeat	250..278	CDD:293786
		PTZ00121	<382..1165	CDD:173412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2649
eggNOG	1	0.900	-	-		E1_2CMIW
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3571
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006031
OrthoInspector	1	1.000	-	-		otm44339
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5253
SonicParanoid	1	1.000	-	-		X4941
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.850