DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10984 and ankrd11

DIOPT Version :9

Sequence 1:	NP_729823.2	Gene:	CG10984 / 39446	FlyBaseID:	FBgn0036305	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	XP_002933704.1	Gene:	ankrd11 / 100485818	XenbaseID:	XB-GENE-1011277	Length:	2761	Species:	Xenopus tropicalis

Alignment Length:	664	Identity:	184/664 - (27%)
Similarity:	294/664 - (44%)	Gaps:	156/664 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 NECKKGDAETDEGSLNEKQEVL--DTKDKSSAEESSNDGKSSDTN---HQGTSAAKRCYSDIEED 131
            |.|::.:.:    ||:|:...|  :.:.::|..|::|..:|||..   .:...:....:|..::|
Frog  2175 NNCRQEEPQ----SLSEESLCLTNEVQAEASDNENNNYTESSDVRPPVAEEPESWSDPFSTADDD 2235

  Fly   132 YE---ESGEDVKKKKRKDSEHGKDVKGASLKLTSRVEKSSKLAATKGSPSGNKSSASNAEKEPA- 192
            .:   .|..|:....::|::                |.||:......|||...:....:|..|.
Frog  2236 LDLGPFSLPDLPSPVKEDAD----------------EISSRQQIVARSPSIIHNECDTSETNPVD 2284

  Fly   193 ----------ETSKNVDIEN-----ETECSDDYKSNDSLYNGGLKVPPLKIVIPQQNCSIDTEGN 242
                      ||:..||:||     |.:|  |:..:.||       .|.|:.  ..||..|.|
Frog  2285 INFQSTVTPNETNDVVDVENKLQICEQKC--DHTEDTSL-------EPTKVA--TDNCKTDCE-- 2336

  Fly   243 VLRTGKVTASRNAALPYVVSSNSDSIDTVITNQSISPHESPQKSNSICSTALDDKNIKLFNDEKN 307
                 .||..::.|.|                   |..|..:|...|        |:.| ||  |
Frog  2337 -----SVTFPQSFAQP-------------------SSPEQTEKEQLI--------NLPL-ND--N 2366

  Fly   308 LRVLRSSHRTGVTSVERS------------SNNSSP--QMQSSSPSPASSNHANDPADVKLSYSN 358
            |:...|:....:|::|:.            .|..:|  .:.:.:|.|.:....:.|...|:
Frog  2367 LQECVSAPEDSLTTLEQECKPAESVVHDSPPNTETPLINITTEAPEPTAKITVDVPKAPKI---- 2427

  Fly   359 MTSSPIPQ----------GHQFDQEAIT---NVPS---PSTSSTSSSKDINPSNVELHPRKRKIR 407
               ..|||          .:|..|.|.|   .:|:   |||...|.:.:...|..: ||||||::
Frog  2428 ---EEIPQRMTRNRAQMLANQNKQNASTIEKEMPAVTVPSTRGKSRATEEEESQTQ-HPRKRKLQ 2488

  Fly   408 PKNTDDSSKNSNAAD--------------SGVNSEESHPHDHPFTNGFQMFLSIRRQIEKKWKSL 458
            ..|.......||.:.              ..:..::..|:....:|.:..:|.||::||:|.|.|
Frog  2489 KPNQLQQQIISNTSQQTREMIQQTLAAIVDAIKLDDIEPYHSDRSNPYFEYLQIRKKIEEKRKIL 2553

  Fly   459 YPVKPRPPQGYNEYLLTKKSYLL--RRNATISVPDI--PRTVPQAMERIYQDQEKARRDLIEAHT 519
            ..:.|:.||.|.||:....||||  :..:.:.:|.|  |.::.:.::.:::.||..|..|...|:
Frog  2554 CYITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLCEPLKELFRQQEAVRGKLRLQHS 2618

  Fly   520 VEREKLCMNVEQEIIRVHSKAARSISGQPAPYSVCTYLKDDEVYNMITPEQDEKEKSARCRFNGR 584
            :|||||.::.|||.:|||.:|||:|:.|..|:|.||.|.|.|||||....|.::.||.|.|||.|
Frog  2619 IEREKLIVSCEQENLRVHCRAARTIANQAVPFSACTMLLDSEVYNMPLENQGDENKSVRDRFNAR 2683

  Fly   585 LLLSWLQDVDDKWEKIKESMVLRHHNEAESLHAVQVMDWNIFAK------RNRLCDNPIEVNLEH 643
            ..||||||||||::::|..:::|..:||.:|:|||.|:|.:..:      ...||.|  ||...:
Frog  2684 QFLSWLQDVDDKYDRMKTCVLMRQQHEAAALNAVQRMEWQLKVQELDPTGHKSLCVN--EVPSFY 2746

  Fly   644 VPIVSVGDDFDTLP 657
            ||:|.|.|||..||
Frog  2747 VPMVDVIDDFVLLP 2760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10984	NP_729823.2	None
ankrd11	XP_002933704.1	ANK repeat	167..198	CDD:293786
		Ank_2	172..264	CDD:372319
		ANK repeat	200..231	CDD:293786
		ANK repeat	233..261	CDD:293786
		PTZ00121	<664..1202	CDD:173412
		SMC_N	887..>1658	CDD:308206
		PHA03247	<1800..2260	CDD:223021	19/104 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2898
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49516
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910